Genular: Defining Cellular Identity and Function

Details for: Cited2

Gene ID: 17684

Symbol: Cited2

Ensembl ID: ENSMUSG00000039910

Description: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

Associated with

Activation of the tfap2 (ap-2) family of transcription factors
(R-MMU-8866907)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to hypoxia
(R-MMU-1234174)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Regulation of gene expression by hypoxia-inducible factor
(R-MMU-1234158)
Rna polymerase ii transcription
(R-MMU-73857)
Transcriptional regulation by the ap-2 (tfap2) family of transcription factors
(R-MMU-8864260)
Adrenal cortex formation
(GO:0035802)
Adrenal gland development
(GO:0030325)
Blood vessel development
(GO:0001568)
Bone morphogenesis
(GO:0060349)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Cardiac neural crest cell development involved in heart development
(GO:0061308)
Cardiac septum morphogenesis
(GO:0060411)
Cell differentiation
(GO:0030154)
Cell population proliferation
(GO:0008283)
Central nervous system development
(GO:0007417)
Chromatin binding
(GO:0003682)
Cranial nerve morphogenesis
(GO:0021602)
Decidualization
(GO:0046697)
Determination of left/right asymmetry in lateral mesoderm
(GO:0003140)
Determination of left/right symmetry
(GO:0007368)
Embryonic camera-type eye morphogenesis
(GO:0048596)
Embryonic heart tube left/right pattern formation
(GO:0060971)
Embryonic placenta development
(GO:0001892)
Embryonic process involved in female pregnancy
(GO:0060136)
Endocardial cushion development
(GO:0003197)
Erythrocyte development
(GO:0048821)
Granulocyte differentiation
(GO:0030851)
Heart development
(GO:0007507)
Heart looping
(GO:0001947)
Hematopoietic progenitor cell differentiation
(GO:0002244)
Histone acetyltransferase binding
(GO:0035035)
In utero embryonic development
(GO:0001701)
Kidney development
(GO:0001822)
Lbd domain binding
(GO:0050693)
Left/right pattern formation
(GO:0060972)
Lens morphogenesis in camera-type eye
(GO:0002089)
Leukocyte differentiation
(GO:0002521)
Liver development
(GO:0001889)
Male gonad development
(GO:0008584)
Molecular function activator activity
(GO:0140677)
Morphogenesis of an epithelium
(GO:0002009)
Multicellular organism development
(GO:0007275)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cardiac muscle cell proliferation
(GO:0060044)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neural tube closure
(GO:0001843)
Neural tube formation
(GO:0001841)
Nodal signaling pathway
(GO:0038092)
Outflow tract morphogenesis
(GO:0003151)
Peripheral nervous system development
(GO:0007422)
Positive regulation of cell-cell adhesion
(GO:0022409)
Positive regulation of cell cycle
(GO:0045787)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of peroxisome proliferator activated receptor signaling pathway
(GO:0035360)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transforming growth factor beta receptor signaling pathway
(GO:0030511)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Pulmonary artery morphogenesis
(GO:0061156)
Regulation of animal organ formation
(GO:0003156)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to estrogen
(GO:0043627)
Response to fluid shear stress
(GO:0034405)
Response to hypoxia
(GO:0001666)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Sex determination
(GO:0007530)
Skeletal muscle cell differentiation
(GO:0035914)
Smad binding
(GO:0046332)
Spleen development
(GO:0048536)
Thymus development
(GO:0048538)
Transcription coactivator activity
(GO:0003713)
Transcription coregulator activity
(GO:0003712)
Transcription corepressor activity
(GO:0003714)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Trophectodermal cell differentiation
(GO:0001829)
Uterus development
(GO:0060065)
Vasculature development
(GO:0001944)
Vasculogenesis
(GO:0001570)
Ventricular septum development
(GO:0003281)
Ventricular septum morphogenesis
(GO:0060412)

Other Information

Proteins

Cbp/p300-interacting transactivator 2

Genular Protein ID: 1753657066

Symbol: CITE2_MOUSE

Name: Cbp/p300-interacting transactivator 2

UniProtKB Accession Codes:

O35740 O35741 O35742 O35743 O55198 Q6PGA9

Database IDs:

Citations:

PubMed ID: 9533950

Title: Msg1 and Mrg1, founding members of a gene family, show distinct patterns of gene expression during mouse embryogenesis.

PubMed ID: 9533950

DOI: 10.1016/s0925-4773(98)00011-2

PubMed ID: 9434189

Title: MSG1 and its related protein MRG1 share a transcription activating domain.

PubMed ID: 9434189

DOI: 10.1016/s0378-1119(97)00551-9

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10593900

Title: MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression.

PubMed ID: 10593900

DOI: 10.1074/jbc.274.51.36159

PubMed ID: 11694877

Title: Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator.

PubMed ID: 11694877

DOI: 10.1038/ng768

PubMed ID: 15051727

Title: Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator.

PubMed ID: 15051727

DOI: 10.1074/jbc.m401489200

PubMed ID: 15475956

Title: Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway.

PubMed ID: 15475956

DOI: 10.1038/ng1446

PubMed ID: 16619037

Title: Cited2 modulates TGF-beta-mediated upregulation of MMP9.

PubMed ID: 16619037

DOI: 10.1038/sj.onc.1209552

PubMed ID: 15750185

Title: Cited2 is required both for heart morphogenesis and establishment of the left-right axis in mouse development.

PubMed ID: 15750185

DOI: 10.1242/dev.01696

PubMed ID: 17537799

Title: Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage.

PubMed ID: 17537799

DOI: 10.1242/dev.004390

PubMed ID: 19457926

Title: The transcription co-factor CITED2 functions during sex determination and early gonad development.

PubMed ID: 19457926

DOI: 10.1093/hmg/ddp237

PubMed ID: 21224256

Title: Loss of Cited2 causes congenital heart disease by perturbing left-right patterning of the body axis.

PubMed ID: 21224256

DOI: 10.1093/hmg/ddq554

Sequence Information:

Length: 269
Mass: 28321
Checksum: 0FFCD8C21E4E3D81
Sequence:

MADHMMAMNH GRFPDGTNGL HHHPAHRMGM GQFPSPHHHQ QQQPQHAFNA LMGEHIHYGA 
GNMNATSGIR HAMGPGTVNG GHPPSALAPA ARFNNSQFMG PPVASQGGSL PASMQLQKLN 
NQYFNHHPYP HNHYMPDLHP TAGHQMNGTN QHFRDCNPKH SGGSSTPGGA GGSGTPGGSG 
GTSGGAGGSS AGGSGGGSTM PASVAHVPAA MLPPNVIDTD FIDEEVLMSL VIEMGLDRIK 
ELPELWLGQN EFDFMTDFVC KQQPSRVSC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cited2

Associated with

Other Information

Msg1 and Mrg1, founding members of a gene family, show distinct patterns of gene expression during mouse embryogenesis. PubMed ID: 9533950

MSG1 and its related protein MRG1 share a transcription activating domain. PubMed ID: 9434189

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. PubMed ID: 10593900

Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator. PubMed ID: 11694877

Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator. PubMed ID: 15051727

Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway. PubMed ID: 15475956

Cited2 modulates TGF-beta-mediated upregulation of MMP9. PubMed ID: 16619037

Cited2 is required both for heart morphogenesis and establishment of the left-right axis in mouse development. PubMed ID: 15750185

Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage. PubMed ID: 17537799

The transcription co-factor CITED2 functions during sex determination and early gonad development. PubMed ID: 19457926

Loss of Cited2 causes congenital heart disease by perturbing left-right patterning of the body axis. PubMed ID: 21224256