Genular: Defining Cellular Identity and Function

Details for: Msh2

Gene ID: 17685

Symbol: Msh2

Ensembl ID: ENSMUSG00000024151

Description: mutS homolog 2

Associated with

Mismatch repair (mmr) directed by msh2:msh3 (mutsbeta)
(R-MMU-5358606)
Mismatch repair (mmr) directed by msh2:msh6 (mutsalpha)
(R-MMU-5358565)
Adp binding
(GO:0043531)
Atp-dependent activity, acting on dna
(GO:0008094)
Atp-dependent dna damage sensor activity
(GO:0140664)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
B cell differentiation
(GO:0030183)
B cell mediated immunity
(GO:0019724)
Cell cycle
(GO:0007049)
Centromeric dna binding
(GO:0019237)
Chromatin binding
(GO:0003682)
Chromosome
(GO:0005694)
Damaged dna binding
(GO:0003684)
Determination of adult lifespan
(GO:0008340)
Dinucleotide insertion or deletion binding
(GO:0032139)
Dinucleotide repeat insertion binding
(GO:0032181)
Dna binding
(GO:0003677)
Dna damage response
(GO:0006974)
Dna repair
(GO:0006281)
Double-strand break repair
(GO:0006302)
Double-stranded dna binding
(GO:0003690)
Four-way junction dna binding
(GO:0000400)
Germ cell development
(GO:0007281)
Guanine/thymine mispair binding
(GO:0032137)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
(GO:0042771)
In utero embryonic development
(GO:0001701)
Isotype switching
(GO:0045190)
Magnesium ion binding
(GO:0000287)
Maintenance of dna repeat elements
(GO:0043570)
Male gonad development
(GO:0008584)
Mismatched dna binding
(GO:0030983)
Mismatch repair
(GO:0006298)
Mitotic intra-s dna damage checkpoint signaling
(GO:0031573)
Mitotic recombination
(GO:0006312)
Mutlalpha complex binding
(GO:0032405)
Mutsalpha complex
(GO:0032301)
Mutsbeta complex
(GO:0032302)
Negative regulation of dna recombination
(GO:0045910)
Negative regulation of neuron apoptotic process
(GO:0043524)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Oxidative phosphorylation
(GO:0006119)
Oxidized purine dna binding
(GO:0032357)
Positive regulation of helicase activity
(GO:0051096)
Positive regulation of isotype switching to iga isotypes
(GO:0048298)
Positive regulation of isotype switching to igg isotypes
(GO:0048304)
Postreplication repair
(GO:0006301)
Protein homodimerization activity
(GO:0042803)
Protein localization to chromatin
(GO:0071168)
Regulation of cell cycle
(GO:0051726)
Response to uv-b
(GO:0010224)
Response to x-ray
(GO:0010165)
Single-stranded dna binding
(GO:0003697)
Single guanine insertion binding
(GO:0032142)
Single thymine insertion binding
(GO:0032143)
Somatic hypermutation of immunoglobulin genes
(GO:0016446)
Somatic recombination of immunoglobulin gene segments
(GO:0016447)
Somatic recombination of immunoglobulin genes involved in immune response
(GO:0002204)

Other Information

Proteins

DNA mismatch repair protein Msh2

Genular Protein ID: 3285858807

Symbol: MSH2_MOUSE

Name: DNA mismatch repair protein Msh2

UniProtKB Accession Codes:

P43247

Database IDs:

Citations:

PubMed ID: 7838728

Title: Cloning and expression of the Xenopus and mouse Msh2 DNA mismatch repair genes.

PubMed ID: 7838728

DOI: 10.1093/nar/22.25.5723

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

Sequence Information:

Length: 935
Mass: 104151
Checksum: 2111E9D5E3A8548A
Sequence:

MAVQPKETLQ LEGAAEAGFV RFFEGMPEKP STTVRLFDRG DFYTAHGEDA LLAAREVFKT 
QGVIKYMGPA GSKTLQSVVL SKMNFESFVK DLLLVRQYRV EVYKNKAGNK ASKENEWYLA 
FKASPGNLSQ FEDILFGNND MSASVGVMGI KMAVVDGQRH VGVGYVDSTQ RKLGLCEFPE 
NDQFSNLEAL LIQIGPKECV LPGGETTGDM GKLRQVIQRG GILITERKRA DFSTKDIYQD 
LNRLLKGKKG EQINSAALPE MENQVAVSSL SAVIKFLELL SDDSNFGQFE LATFDFSQYM 
KLDMAAVRAL NLFQGSVEDT TGSQSLAALL NKCKTAQGQR LVNQWIKQPL MDRNRIEERL 
NLVEAFVEDS ELRQSLQEDL LRRFPDLNRL AKKFQRQAAN LQDCYRLYQG INQLPSVIQA 
LEKYEGRHQA LLLAVFVTPL IDLRSDFSKF QEMIETTLDM DQVENHEFLV KPSFDPNLSE 
LREVMDGLEK KMQSTLINAA RGLGLDPGKQ IKLDSSAQFG YYFRVTCKEE KVLRNNKNFS 
TVDIQKNGVK FTNSELSSLN EEYTKNKGEY EEAQDAIVKE IVNISSGYVE PMQTLNDVLA 
HLDAIVSFAH VSNAAPVPYV RPVILEKGKG RIILKASRHA CVEVQDEVAF IPNDVHFEKD 
KQMFHIITGP NMGGKSTYIR QTGVIVLMAQ IGCFVPCESA EVSIVDCILA RVGAGDSQLK 
GVSTFMAEML ETASILRSAT KDSLIIIDEL GRGTSTYDGF GLAWAISDYI ATKIGAFCMF 
ATHFHELTAL ANQIPTVNNL HVTALTTEET LTMLYQVKKG VCDQSFGIHV AELANFPRHV 
IACAKQKALE LEEFQNIGTS LGCDEAEPAA KRRCLEREQG EKIILEFLSK VKQVPFTAMS 
EESISAKLKQ LKAEVVAKNN SFVNEIISRI KAPAP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Msh2

Associated with

Other Information

Cloning and expression of the Xenopus and mouse Msh2 DNA mismatch repair genes. PubMed ID: 7838728

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Database document:

PubMed ID: 7838728

PubMed ID: 15489334

PubMed ID: 21183079

PubMed ID: 23806337