Genular: Defining Cellular Identity and Function

Details for: Sik1

Gene ID: 17691

Symbol: Sik1

Ensembl ID: ENSMUSG00000024042

Description: salt inducible kinase 1

Associated with

14-3-3 protein binding
(GO:0071889)
Anoikis
(GO:0043276)
Atp binding
(GO:0005524)
Camp response element binding protein binding
(GO:0008140)
Cardiac muscle cell differentiation
(GO:0055007)
Cell cycle
(GO:0007049)
Cell differentiation
(GO:0030154)
Cytoplasm
(GO:0005737)
Entrainment of circadian clock by photoperiod
(GO:0043153)
Histone deacetylase binding
(GO:0042826)
Intracellular signal transduction
(GO:0035556)
Kinase activity
(GO:0016301)
Magnesium ion binding
(GO:0000287)
Metal ion binding
(GO:0046872)
Multicellular organism development
(GO:0007275)
Negative regulation of creb transcription factor activity
(GO:0032792)
Negative regulation of gluconeogenesis
(GO:0045721)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of triglyceride biosynthetic process
(GO:0010868)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Phosphorylation
(GO:0016310)
Positive regulation of anoikis
(GO:2000210)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of cell differentiation
(GO:0045595)
Regulation of mitotic cell cycle
(GO:0007346)
Regulation of myotube differentiation
(GO:0010830)
Regulation of sodium ion transport
(GO:0002028)
Rhythmic process
(GO:0048511)
Transferase activity
(GO:0016740)

Other Information

Proteins

Serine/threonine-protein kinase SIK1

Genular Protein ID: 169675175

Symbol: SIK1_MOUSE

Name: Serine/threonine-protein kinase SIK1

UniProtKB Accession Codes:

Q60670 Q3UR46

Database IDs:

Citations:

PubMed ID: 7893599

Title: Identification of novel protein kinases expressed in the myocardium of the developing mouse heart.

PubMed ID: 7893599

DOI: 10.1016/0925-4773(94)90056-6

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 12200423

Title: ACTH-induced nucleocytoplasmic translocation of salt-inducible kinase. Implication in the protein kinase A-activated gene transcription in mouse adrenocortical tumor cells.

PubMed ID: 12200423

DOI: 10.1074/jbc.m204602200

PubMed ID: 15511237

Title: Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm.

PubMed ID: 15511237

DOI: 10.1111/j.1432-1033.2004.04372.x

PubMed ID: 15177563

Title: snf1lk encodes a protein kinase that may function in cell cycle regulation.

PubMed ID: 15177563

DOI: 10.1016/j.ygeno.2003.12.007

PubMed ID: 16148943

Title: The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism.

PubMed ID: 16148943

DOI: 10.1038/nature03967

PubMed ID: 16817901

Title: Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade.

PubMed ID: 16817901

DOI: 10.1111/j.1742-4658.2006.05291.x

PubMed ID: 17468767

Title: SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes.

PubMed ID: 17468767

DOI: 10.1038/nm1573

PubMed ID: 19622832

Title: SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis.

PubMed ID: 19622832

DOI: 10.1126/scisignal.2000369

PubMed ID: 19244231

Title: Salt-inducible kinase regulates hepatic lipogenesis by controlling SREBP-1c phosphorylation.

PubMed ID: 19244231

DOI: 10.1074/jbc.m900096200

PubMed ID: 20140255

Title: Lack of sik1 in mouse embryonic stem cells impairs cardiomyogenesis by down-regulating the cyclin-dependent kinase inhibitor p57kip2.

PubMed ID: 20140255

DOI: 10.1371/journal.pone.0009029

PubMed ID: 23993098

Title: The CRTC1-SIK1 pathway regulates entrainment of the circadian clock.

PubMed ID: 23993098

DOI: 10.1016/j.cell.2013.08.004

Sequence Information:

Length: 779
Mass: 85115
Checksum: 9C4D25CCF0C0D06D
Sequence:

MVIMSEFSAV PSGTGQGQQK PLRVGFYDVE RTLGKGNFAV VKLARHRVTK TQVAIKIIDK 
TRLDSSNLEK IYREVQLMKL LNHPNIIKLY QVMETKDMLY IVTEFAKNGE MFDYLTSNGH 
LSENEARQKF WQILSAVEYC HNHHIVHRDL KTENLLLDSN MDIKLADFGF GNFYKPGEPL 
STWCGSPPYA APEVFEGKEY EGPQLDVWSL GVVLYVLVCG SLPFDGPNLP TLRQRVLEGR 
FRIPFFMSQD CETLIRRMLV VDPAKRITIA QIRQHRWMQA DPTLLQQDDP AFDMQGYTSN 
LGDYNEQVLG IMQALGIDRQ RTIESLQNSS YNHFAAIYYL LLERLKEHRS AQPSSRPTPA 
PTRQPQLRSS DLSSLEVPQE ILPCDPFRPS LLCPQPQALA QSVLQAEIDC DLHSSLQPLL 
FPLDTNCSGV FRHRSISPSS LLDTAISEEA RQGPSLEEEQ EVQEPLPGST GRRHTLAEVS 
THFSPLNPPC IIVSSSATAS PSEGTSSDSC LPFSASEGPA GLGSGLATPG LLGTSSPVRL 
ASPFLGSQSA TPVLQTQAGL GTAVLPPVSF QEGRRASDTS LTQGLKAFRQ QLRKNARTKG 
FLGLNKIKGL ARQVCQSSVR TPRGGMSTFH TPAPSSGLQG CTTSNREGRS LLEEVLHQQR 
LLQLQHHSST AAASSGCQQG PQLSPVPYVL APCDSLLVSG IPLLPTPLLQ AGMSPVASAA 
HLLDTHLHIS AGPVALPTGP LPQCLTRLSP GCDPAGLPQG DCEMEDLTSG QRGTFVLVQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Sik1

Associated with

Other Information

Identification of novel protein kinases expressed in the myocardium of the developing mouse heart. PubMed ID: 7893599

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

ACTH-induced nucleocytoplasmic translocation of salt-inducible kinase. Implication in the protein kinase A-activated gene transcription in mouse adrenocortical tumor cells. PubMed ID: 12200423

Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm. PubMed ID: 15511237

snf1lk encodes a protein kinase that may function in cell cycle regulation. PubMed ID: 15177563

The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. PubMed ID: 16148943

Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade. PubMed ID: 16817901

SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. PubMed ID: 17468767

SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis. PubMed ID: 19622832

Salt-inducible kinase regulates hepatic lipogenesis by controlling SREBP-1c phosphorylation. PubMed ID: 19244231

Lack of sik1 in mouse embryonic stem cells impairs cardiomyogenesis by down-regulating the cyclin-dependent kinase inhibitor p57kip2. PubMed ID: 20140255

The CRTC1-SIK1 pathway regulates entrainment of the circadian clock. PubMed ID: 23993098