AGER | ENSG00000204305 | NCBI 177

Details for: AGER

Gene ID: 177

Symbol: AGER

Ensembl ID: ENSG00000204305

Description: advanced glycosylation end-product specific receptor

Associated with

Advanced glycosylation endproduct receptor signaling
(R-HSA-879415)
Cytokine signaling in immune system
(R-HSA-1280215)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-HSA-168928)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Signaling by interleukins
(R-HSA-449147)
Tak1-dependent ikk and nf-kappa-b activation
(R-HSA-445989)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Traf6 mediated nf-kb activation
(R-HSA-933542)
Trif (ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Advanced glycation end-product receptor activity
(GO:0050785)
Amyloid-beta binding
(GO:0001540)
Apical plasma membrane
(GO:0016324)
Astrocyte activation
(GO:0048143)
Cell adhesion
(GO:0007155)
Cell junction
(GO:0030054)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to amyloid-beta
(GO:1904646)
Extracellular region
(GO:0005576)
Fibrillar center
(GO:0001650)
Glucose mediated signaling pathway
(GO:0010255)
Identical protein binding
(GO:0042802)
Induction of positive chemotaxis
(GO:0050930)
Inflammatory response
(GO:0006954)
Laminin receptor activity
(GO:0005055)
Learning or memory
(GO:0007611)
Microglial cell activation
(GO:0001774)
Molecular adaptor activity
(GO:0060090)
Negative regulation of blood circulation
(GO:1903523)
Negative regulation of connective tissue replacement involved in inflammatory response wound healing
(GO:1904597)
Negative regulation of interleukin-10 production
(GO:0032693)
Negative regulation of long-term synaptic depression
(GO:1900453)
Negative regulation of long-term synaptic potentiation
(GO:1900272)
Neuron projection development
(GO:0031175)
Plasma membrane
(GO:0005886)
Positive regulation of activated t cell proliferation
(GO:0042104)
Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
(GO:1902961)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of dendritic cell differentiation
(GO:2001200)
Positive regulation of endothelin production
(GO:1904472)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of heterotypic cell-cell adhesion
(GO:0034116)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of monocyte chemotactic protein-1 production
(GO:0071639)
Positive regulation of monocyte extravasation
(GO:2000439)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of non-canonical nf-kappab signal transduction
(GO:1901224)
Positive regulation of p38mapk cascade
(GO:1900745)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Postsynapse
(GO:0098794)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein localization to membrane
(GO:0072657)
Regulation of cd4-positive, alpha-beta t cell activation
(GO:2000514)
Regulation of inflammatory response
(GO:0050727)
Regulation of long-term synaptic potentiation
(GO:1900271)
Regulation of non-canonical nf-kappab signal transduction
(GO:1901222)
Regulation of p38mapk cascade
(GO:1900744)
Regulation of spontaneous synaptic transmission
(GO:0150003)
Regulation of synaptic plasticity
(GO:0048167)
Regulation of t cell mediated cytotoxicity
(GO:0001914)
Response to amyloid-beta
(GO:1904645)
Response to hypoxia
(GO:0001666)
Response to wounding
(GO:0009611)
S100 protein binding
(GO:0044548)
Scavenger receptor activity
(GO:0005044)
Signaling receptor activity
(GO:0038023)
Transcytosis
(GO:0045056)
Transmembrane signaling receptor activity
(GO:0004888)
Transport across blood-brain barrier
(GO:0150104)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 17.9369
Cell Significance Index: -2.7900
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 15.4942
Cell Significance Index: -3.9300
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 10.0552
Cell Significance Index: -4.0900
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 9.7115
Cell Significance Index: -4.5900
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 4.3677
Cell Significance Index: -4.1700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 3.0739
Cell Significance Index: -3.7900
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 2.1939
Cell Significance Index: 23.3100
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 1.5846
Cell Significance Index: -4.2500
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 1.2632
Cell Significance Index: 20.8200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 1.0872
Cell Significance Index: -4.2900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.0414
Cell Significance Index: 198.1800
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.9651
Cell Significance Index: 50.2700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7966
Cell Significance Index: 78.8000
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 0.7174
Cell Significance Index: -1.5700
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6330
Cell Significance Index: 571.5600
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.4973
Cell Significance Index: 2.9800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4221
Cell Significance Index: 68.6500
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3953
Cell Significance Index: 43.0000
Cell Name: thymocyte (CL0000893)
Fold Change: 0.3071
Cell Significance Index: 3.8800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2439
Cell Significance Index: 14.6400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2139
Cell Significance Index: 14.7900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.1560
Cell Significance Index: 18.1800
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.1440
Cell Significance Index: 2.0200
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1398
Cell Significance Index: 27.7500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1141
Cell Significance Index: 3.1900
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.0998
Cell Significance Index: 1.4000
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.0942
Cell Significance Index: 1.3500
Cell Name: pulmonary capillary endothelial cell (CL4028001)
Fold Change: 0.0789
Cell Significance Index: 1.0800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0781
Cell Significance Index: 59.1100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0618
Cell Significance Index: 1.7800
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.0597
Cell Significance Index: 0.4600
Cell Name: decidual cell (CL2000002)
Fold Change: 0.0586
Cell Significance Index: 0.9400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0585
Cell Significance Index: 8.5000
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0535
Cell Significance Index: 1.1600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0490
Cell Significance Index: 2.2200
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.0476
Cell Significance Index: 0.6500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0448
Cell Significance Index: 5.2800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0445
Cell Significance Index: 1.1900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0375
Cell Significance Index: 1.9500
Cell Name: epidermal cell (CL0000362)
Fold Change: 0.0355
Cell Significance Index: 0.0800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0351
Cell Significance Index: 1.9700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0337
Cell Significance Index: 4.6300
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0270
Cell Significance Index: 14.7400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0265
Cell Significance Index: 4.7700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0186
Cell Significance Index: 8.2300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0164
Cell Significance Index: 3.2800
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.0157
Cell Significance Index: 0.2900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0120
Cell Significance Index: 0.3000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0114
Cell Significance Index: 0.4000
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0112
Cell Significance Index: 1.4400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0058
Cell Significance Index: 0.7100
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0041
Cell Significance Index: 0.2100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0036
Cell Significance Index: 6.7100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0036
Cell Significance Index: 5.5300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0035
Cell Significance Index: 1.2700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0030
Cell Significance Index: 0.0500
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0013
Cell Significance Index: 2.4300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0000
Cell Significance Index: -0.0200
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0020
Cell Significance Index: -0.1300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0021
Cell Significance Index: -2.8200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0040
Cell Significance Index: -2.9400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0045
Cell Significance Index: -3.3500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0046
Cell Significance Index: -0.5300
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0054
Cell Significance Index: -0.1600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0058
Cell Significance Index: -2.6200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0058
Cell Significance Index: -3.2800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0078
Cell Significance Index: -4.8700
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0092
Cell Significance Index: -0.2500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0099
Cell Significance Index: -0.2100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0116
Cell Significance Index: -1.9800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0132
Cell Significance Index: -1.3500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0140
Cell Significance Index: -0.8600
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0152
Cell Significance Index: -4.3800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0154
Cell Significance Index: -0.7300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0158
Cell Significance Index: -0.2700
Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: -0.0173
Cell Significance Index: -0.1900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0179
Cell Significance Index: -0.9400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0188
Cell Significance Index: -3.9700
Cell Name: pulmonary alveolar type 2 cell (CL0002063)
Fold Change: -0.0193
Cell Significance Index: -0.1600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0252
Cell Significance Index: -1.7800
Cell Name: peg cell (CL4033014)
Fold Change: -0.0268
Cell Significance Index: -0.6200
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0298
Cell Significance Index: -0.1800
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0300
Cell Significance Index: -3.8700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0333
Cell Significance Index: -2.1000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0336
Cell Significance Index: -2.5800
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0338
Cell Significance Index: -0.3500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0373
Cell Significance Index: -3.8800
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0443
Cell Significance Index: -0.9700
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0463
Cell Significance Index: -1.9000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0468
Cell Significance Index: -1.2500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0483
Cell Significance Index: -2.2500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0518
Cell Significance Index: -3.8600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0549
Cell Significance Index: -4.3500
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.0552
Cell Significance Index: -0.6900
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0578
Cell Significance Index: -1.5200
Cell Name: helper T cell (CL0000912)
Fold Change: -0.0584
Cell Significance Index: -0.8300
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0588
Cell Significance Index: -1.2200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0653
Cell Significance Index: -2.0900
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0732
Cell Significance Index: -1.8700
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0756
Cell Significance Index: -1.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** AGER is a transmembrane receptor that belongs to the immunoglobulin superfamily. It is composed of three immunoglobulin-like domains and a collagen-like domain. The receptor is expressed on various cell types, including epithelial cells, endothelial cells, and immune cells. AGER interacts with a wide range of ligands, including advanced glycosylation end-products (AGEs), amyloid-β, and other pro-inflammatory molecules. **Pathways and Functions:** AGER's signaling pathways are complex and multifaceted. Upon binding to its ligands, AGER activates various downstream signaling cascades, including: 1. **Inflammatory Response:** AGER's interaction with AGEs and other ligands triggers the activation of NF-κB, leading to the production of pro-inflammatory cytokines and chemokines. 2. **Cell Signaling:** AGER's binding to its ligands also activates the MAPK and JNK cascades, leading to the regulation of cell proliferation, differentiation, and survival. 3. **Immune Response:** AGER's interaction with pattern recognition receptors (PRRs) like TLRs and NLRs triggers the activation of the innate immune response, leading to the production of cytokines and chemokines. 4. **Neuroinflammation:** AGER's binding to amyloid-β and other ligands triggers the activation of microglial cells, leading to the production of pro-inflammatory cytokines and chemokines. **Clinical Significance:** AGER's dysregulation has been implicated in various disease states, including: 1. **Diabetes:** AGER's interaction with AGEs contributes to the development of diabetic complications, such as nephropathy and retinopathy. 2. **Atherosclerosis:** AGER's binding to AGEs and other ligands contributes to the development of atherosclerosis by promoting inflammation and endothelial dysfunction. 3. **Neurodegenerative Diseases:** AGER's interaction with amyloid-β and other ligands contributes to the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Cancer:** AGER's expression is often upregulated in cancer cells, contributing to the promotion of tumor growth and metastasis. In conclusion, AGER's multifunctional nature and its interaction with various ligands make it a key player in various physiological and pathological processes. Further research is needed to fully elucidate the mechanisms by which AGER contributes to disease states and to explore potential therapeutic strategies for the treatment of AGER-related disorders. **Recommendations:** 1. **Future Research Directions:** Investigate the role of AGER in different disease states, including cancer, neurodegenerative diseases, and cardiovascular disease. 2. **Therapeutic Strategies:** Develop targeted therapies that inhibit AGER's signaling pathways, potentially reducing the risk of AGER-related disorders. 3. **Diagnostic Biomarkers:** Identify potential biomarkers for AGER-related disorders, enabling early detection and treatment. By understanding the complex mechanisms by which AGER contributes to disease states, we can develop effective therapeutic strategies to mitigate its impact and improve patient outcomes.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Advanced glycosylation end product-specific receptor
B4DNX3_HUMAN

Genular Protein ID: 1536672251

Symbol: RAGE_HUMAN

Name: Advanced glycosylation end product-specific receptor

UniProtKB Accession Codes:

Q15109 A2BFI7 A6NKF0 A7Y2U9 B0V176 Q15279 Q3L1R4 Q3L1R5 Q3L1R6 Q3L1R7 Q3L1R8 Q3L1S0 Q86SN1 Q9H2X7 Q9Y3R3 V5R6A3

Database IDs:

Citations:

PubMed ID: 1378843

Title: Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.

PubMed ID: 1378843

DOI: 10.1016/s0021-9258(18)42138-2

PubMed ID: 7835890

Title: Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3.

PubMed ID: 7835890

DOI: 10.1006/geno.1994.1517

PubMed ID: 12495433

Title: Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury.

PubMed ID: 12495433

DOI: 10.1042/bj20021371

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 18089847

Title: Identification, classification, and expression of RAGE gene splice variants.

PubMed ID: 18089847

DOI: 10.1096/fj.07-9909com

PubMed ID: 24260107

Title: Alternative splicing of the RAGE cytoplasmic domain regulates cell signaling and function.

PubMed ID: 24260107

DOI: 10.1371/journal.pone.0078267

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11375354

Title: Effects of novel polymorphisms in the RAGE gene on transcriptional regulation and their association with diabetic retinopathy.

PubMed ID: 11375354

DOI: 10.2337/diabetes.50.6.1505

PubMed ID: 19386136

Title: Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function.

PubMed ID: 19386136

DOI: 10.1186/1471-2091-10-11

PubMed ID: 19906677

Title: RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease.

PubMed ID: 19906677

DOI: 10.1096/fj.09-139634

PubMed ID: 21559403

Title: S100A14 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glycation end products (RAGE).

PubMed ID: 21559403

DOI: 10.1371/journal.pone.0019375

PubMed ID: 21829704

Title: TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding.

PubMed ID: 21829704

DOI: 10.1371/journal.pone.0023132

PubMed ID: 23284645

Title: Disulfide bonds within the C2 domain of RAGE play key roles in its dimerization and biogenesis.

PubMed ID: 23284645

DOI: 10.1371/journal.pone.0050736

PubMed ID: 27572515

Title: High Mobility Group Box Protein 1 Boosts Endothelial Albumin Transcytosis through the RAGE/Src/Caveolin-1 Pathway.

PubMed ID: 27572515

DOI: 10.1038/srep32180

PubMed ID: 28515150

Title: Receptor for advanced glycation end products is targeted by FBXO10 for ubiquitination and degradation.

PubMed ID: 28515150

DOI: 10.1096/fj.201700031r

PubMed ID: 34743181

Title: LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome.

PubMed ID: 34743181

DOI: 10.1038/s41420-021-00729-0

PubMed ID: 33436632

Title: Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis.

PubMed ID: 33436632

DOI: 10.1038/s41467-020-20577-3

PubMed ID: 20943659

Title: The 1.5 A crystal structure of human receptor for advanced glycation endproducts (RAGE) ectodomains reveals unique features determining ligand binding.

PubMed ID: 20943659

DOI: 10.1074/jbc.m110.169276

PubMed ID: 20947022

Title: Structural basis for ligand recognition and activation of RAGE.

PubMed ID: 20947022

DOI: 10.1016/j.str.2010.05.017

PubMed ID: 21565706

Title: Advanced glycation end product recognition by the receptor for AGEs.

PubMed ID: 21565706

DOI: 10.1016/j.str.2011.02.013

PubMed ID: 24081950

Title: RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA.

PubMed ID: 24081950

DOI: 10.1084/jem.20120201

Sequence Information:

Length: 404
Mass: 42803
Checksum: 0D584C436C30CCE7
Sequence:

MAAGTAVGAW VLVLSLWGAV VGAQNITARI GEPLVLKCKG APKKPPQRLE WKLNTGRTEA 
WKVLSPQGGG PWDSVARVLP NGSLFLPAVG IQDEGIFRCQ AMNRNGKETK SNYRVRVYQI 
PGKPEIVDSA SELTAGVPNK VGTCVSEGSY PAGTLSWHLD GKPLVPNEKG VSVKEQTRRH 
PETGLFTLQS ELMVTPARGG DPRPTFSCSF SPGLPRHRAL RTAPIQPRVW EPVPLEEVQL 
VVEPEGGAVA PGGTVTLTCE VPAQPSPQIH WMKDGVPLPL PPSPVLILPE IGPQDQGTYS 
CVATHSSHGP QESRAVSISI IEPGEEGPTA GSVGGSGLGT LALALGILGG LGTAALLIGV 
ILWQRRQRRG EERKAPENQE EEEERAELNQ SEEPEAGESS TGGP

Genular Protein ID: 3351442283

Symbol: B4DNX3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DNX3

Database IDs:

Sequence Information:

Length: 435
Mass: 45980
Checksum: 6FF01FC403107051
Sequence:

MGAGERVQAP PRAEATAGRG ADRARTLEGS RMAAGTAVGA WVLVLSLWGA VVGAQNITAR 
IGEPLVLKCK GAPKKPPQRL EWKLNTGRTE AWKVLSPQGG GPWDSVARVL PNGSLFLPAV 
GIQDEGIFRC QAMNRNGKET KSNYRVRVYQ IPGKPEIVDS ASELTAGVPN KVGTCVSEGS 
YPAGTLSWHL DGKPLVPNEK GVSVKEQTRR HPETGLFTLQ SELMVTPARG GDPRPTFSCS 
FSPGLPRHRA LRTAPIQPRV WEPVPLEEVQ LVVEPEGGAV APGGTVTLTC EVPAQPSPQI 
HWMKDGVPLP LPPSPVLILP EIGPQDQGTY SCVATHSSHG PQESRAVSIS IIEPGEEGPT 
AGSVGGSGLG TLALALGILG GLGTAALLIG VILWQRRQRR GEERKAPENQ EEEEERAELN 
QSEEPEAGES STGGP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: AGER

Associated with

Cells (max top 100)

Other Information

Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. PubMed ID: 1378843

Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3. PubMed ID: 7835890

Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury. PubMed ID: 12495433

Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. PubMed ID: 14656967

Identification, classification, and expression of RAGE gene splice variants. PubMed ID: 18089847

Alternative splicing of the RAGE cytoplasmic domain regulates cell signaling and function. PubMed ID: 24260107

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Effects of novel polymorphisms in the RAGE gene on transcriptional regulation and their association with diabetic retinopathy. PubMed ID: 11375354

Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function. PubMed ID: 19386136

RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease. PubMed ID: 19906677

S100A14 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glycation end products (RAGE). PubMed ID: 21559403

TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding. PubMed ID: 21829704

Disulfide bonds within the C2 domain of RAGE play key roles in its dimerization and biogenesis. PubMed ID: 23284645

High Mobility Group Box Protein 1 Boosts Endothelial Albumin Transcytosis through the RAGE/Src/Caveolin-1 Pathway. PubMed ID: 27572515

Receptor for advanced glycation end products is targeted by FBXO10 for ubiquitination and degradation. PubMed ID: 28515150

LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome. PubMed ID: 34743181

Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis. PubMed ID: 33436632

The 1.5 A crystal structure of human receptor for advanced glycation endproducts (RAGE) ectodomains reveals unique features determining ligand binding. PubMed ID: 20943659

Structural basis for ligand recognition and activation of RAGE. PubMed ID: 20947022

Advanced glycation end product recognition by the receptor for AGEs. PubMed ID: 21565706

RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA. PubMed ID: 24081950