AGER | ENSG00000204305 | NCBI 177

Details for: AGER

Gene ID: 177

Symbol: AGER

Ensembl ID: ENSG00000204305

Description: advanced glycosylation end-product specific receptor

Associated with

Advanced glycosylation endproduct receptor signaling
(R-HSA-879415)
Cytokine signaling in immune system
(R-HSA-1280215)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-HSA-168928)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Signaling by interleukins
(R-HSA-449147)
Tak1-dependent ikk and nf-kappa-b activation
(R-HSA-445989)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Traf6 mediated nf-kb activation
(R-HSA-933542)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Advanced glycation end-product receptor activity
(GO:0050785)
Amyloid-beta binding
(GO:0001540)
Apical plasma membrane
(GO:0016324)
Astrocyte activation
(GO:0048143)
Cell adhesion
(GO:0007155)
Cell junction
(GO:0030054)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to amyloid-beta
(GO:1904646)
Endocytosis
(GO:0006897)
Extracellular region
(GO:0005576)
Fibrillar center
(GO:0001650)
Glucose mediated signaling pathway
(GO:0010255)
Identical protein binding
(GO:0042802)
Induction of positive chemotaxis
(GO:0050930)
Inflammatory response
(GO:0006954)
Laminin receptor activity
(GO:0005055)
Learning or memory
(GO:0007611)
Microglial cell activation
(GO:0001774)
Molecular adaptor activity
(GO:0060090)
Negative regulation of blood circulation
(GO:1903523)
Negative regulation of interleukin-10 production
(GO:0032693)
Negative regulation of long-term synaptic depression
(GO:1900453)
Negative regulation of long-term synaptic potentiation
(GO:1900272)
Neuron projection development
(GO:0031175)
Plasma membrane
(GO:0005886)
Positive regulation of activated t cell proliferation
(GO:0042104)
Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
(GO:1902961)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of dendritic cell differentiation
(GO:2001200)
Positive regulation of endothelin production
(GO:1904472)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of heterotypic cell-cell adhesion
(GO:0034116)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of monocyte chemotactic protein-1 production
(GO:0071639)
Positive regulation of monocyte extravasation
(GO:2000439)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of non-canonical nf-kappab signal transduction
(GO:1901224)
Positive regulation of p38mapk cascade
(GO:1900745)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Postsynapse
(GO:0098794)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein localization to membrane
(GO:0072657)
Regulation of cd4-positive, alpha-beta t cell activation
(GO:2000514)
Regulation of inflammatory response
(GO:0050727)
Regulation of long-term synaptic potentiation
(GO:1900271)
Regulation of non-canonical nf-kappab signal transduction
(GO:1901222)
Regulation of p38mapk cascade
(GO:1900744)
Regulation of spontaneous synaptic transmission
(GO:0150003)
Regulation of synaptic plasticity
(GO:0048167)
Regulation of t cell mediated cytotoxicity
(GO:0001914)
Response to amyloid-beta
(GO:1904645)
Response to hypoxia
(GO:0001666)
Response to wounding
(GO:0009611)
S100 protein binding
(GO:0044548)
Scavenger receptor activity
(GO:0005044)
Signaling receptor activity
(GO:0038023)
Transcytosis
(GO:0045056)
Transmembrane signaling receptor activity
(GO:0004888)
Transport across blood-brain barrier
(GO:0150104)

Other Information

Proteins

Advanced glycosylation end product-specific receptor
B4DNX3_HUMAN

Genular Protein ID: 1536672251

Symbol: RAGE_HUMAN

Name: Advanced glycosylation end product-specific receptor

UniProtKB Accession Codes:

Q15109 A2BFI7 A6NKF0 A7Y2U9 B0V176 Q15279 Q3L1R4 Q3L1R5 Q3L1R6 Q3L1R7 Q3L1R8 Q3L1S0 Q86SN1 Q9H2X7 Q9Y3R3 V5R6A3

Database IDs:

Citations:

PubMed ID: 1378843

Title: Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.

PubMed ID: 1378843

DOI: 10.1016/s0021-9258(18)42138-2

PubMed ID: 7835890

Title: Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3.

PubMed ID: 7835890

DOI: 10.1006/geno.1994.1517

PubMed ID: 12495433

Title: Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury.

PubMed ID: 12495433

DOI: 10.1042/bj20021371

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 18089847

Title: Identification, classification, and expression of RAGE gene splice variants.

PubMed ID: 18089847

DOI: 10.1096/fj.07-9909com

PubMed ID: 24260107

Title: Alternative splicing of the RAGE cytoplasmic domain regulates cell signaling and function.

PubMed ID: 24260107

DOI: 10.1371/journal.pone.0078267

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11375354

Title: Effects of novel polymorphisms in the RAGE gene on transcriptional regulation and their association with diabetic retinopathy.

PubMed ID: 11375354

DOI: 10.2337/diabetes.50.6.1505

PubMed ID: 19386136

Title: Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function.

PubMed ID: 19386136

DOI: 10.1186/1471-2091-10-11

PubMed ID: 19906677

Title: RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease.

PubMed ID: 19906677

DOI: 10.1096/fj.09-139634

PubMed ID: 21559403

Title: S100A14 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glycation end products (RAGE).

PubMed ID: 21559403

DOI: 10.1371/journal.pone.0019375

PubMed ID: 21829704

Title: TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding.

PubMed ID: 21829704

DOI: 10.1371/journal.pone.0023132

PubMed ID: 23284645

Title: Disulfide bonds within the C2 domain of RAGE play key roles in its dimerization and biogenesis.

PubMed ID: 23284645

DOI: 10.1371/journal.pone.0050736

PubMed ID: 27572515

Title: High Mobility Group Box Protein 1 Boosts Endothelial Albumin Transcytosis through the RAGE/Src/Caveolin-1 Pathway.

PubMed ID: 27572515

DOI: 10.1038/srep32180

PubMed ID: 28515150

Title: Receptor for advanced glycation end products is targeted by FBXO10 for ubiquitination and degradation.

PubMed ID: 28515150

DOI: 10.1096/fj.201700031r

PubMed ID: 34743181

Title: LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome.

PubMed ID: 34743181

DOI: 10.1038/s41420-021-00729-0

PubMed ID: 20943659

Title: The 1.5 A crystal structure of human receptor for advanced glycation endproducts (RAGE) ectodomains reveals unique features determining ligand binding.

PubMed ID: 20943659

DOI: 10.1074/jbc.m110.169276

PubMed ID: 20947022

Title: Structural basis for ligand recognition and activation of RAGE.

PubMed ID: 20947022

DOI: 10.1016/j.str.2010.05.017

PubMed ID: 21565706

Title: Advanced glycation end product recognition by the receptor for AGEs.

PubMed ID: 21565706

DOI: 10.1016/j.str.2011.02.013

PubMed ID: 24081950

Title: RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA.

PubMed ID: 24081950

DOI: 10.1084/jem.20120201

Sequence Information:

Length: 404
Mass: 42803
Checksum: 0D584C436C30CCE7
Sequence:

MAAGTAVGAW VLVLSLWGAV VGAQNITARI GEPLVLKCKG APKKPPQRLE WKLNTGRTEA 
WKVLSPQGGG PWDSVARVLP NGSLFLPAVG IQDEGIFRCQ AMNRNGKETK SNYRVRVYQI 
PGKPEIVDSA SELTAGVPNK VGTCVSEGSY PAGTLSWHLD GKPLVPNEKG VSVKEQTRRH 
PETGLFTLQS ELMVTPARGG DPRPTFSCSF SPGLPRHRAL RTAPIQPRVW EPVPLEEVQL 
VVEPEGGAVA PGGTVTLTCE VPAQPSPQIH WMKDGVPLPL PPSPVLILPE IGPQDQGTYS 
CVATHSSHGP QESRAVSISI IEPGEEGPTA GSVGGSGLGT LALALGILGG LGTAALLIGV 
ILWQRRQRRG EERKAPENQE EEEERAELNQ SEEPEAGESS TGGP

Genular Protein ID: 3351442283

Symbol: B4DNX3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DNX3

Database IDs:

Sequence Information:

Length: 435
Mass: 45980
Checksum: 6FF01FC403107051
Sequence:

MGAGERVQAP PRAEATAGRG ADRARTLEGS RMAAGTAVGA WVLVLSLWGA VVGAQNITAR 
IGEPLVLKCK GAPKKPPQRL EWKLNTGRTE AWKVLSPQGG GPWDSVARVL PNGSLFLPAV 
GIQDEGIFRC QAMNRNGKET KSNYRVRVYQ IPGKPEIVDS ASELTAGVPN KVGTCVSEGS 
YPAGTLSWHL DGKPLVPNEK GVSVKEQTRR HPETGLFTLQ SELMVTPARG GDPRPTFSCS 
FSPGLPRHRA LRTAPIQPRV WEPVPLEEVQ LVVEPEGGAV APGGTVTLTC EVPAQPSPQI 
HWMKDGVPLP LPPSPVLILP EIGPQDQGTY SCVATHSSHG PQESRAVSIS IIEPGEEGPT 
AGSVGGSGLG TLALALGILG GLGTAALLIG VILWQRRQRR GEERKAPENQ EEEEERAELN 
QSEEPEAGES STGGP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: AGER

Associated with

Other Information

Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. PubMed ID: 1378843

Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3. PubMed ID: 7835890

Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury. PubMed ID: 12495433

Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. PubMed ID: 14656967

Identification, classification, and expression of RAGE gene splice variants. PubMed ID: 18089847

Alternative splicing of the RAGE cytoplasmic domain regulates cell signaling and function. PubMed ID: 24260107

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Effects of novel polymorphisms in the RAGE gene on transcriptional regulation and their association with diabetic retinopathy. PubMed ID: 11375354

Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function. PubMed ID: 19386136

RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease. PubMed ID: 19906677

S100A14 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glycation end products (RAGE). PubMed ID: 21559403

TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding. PubMed ID: 21829704

Disulfide bonds within the C2 domain of RAGE play key roles in its dimerization and biogenesis. PubMed ID: 23284645

High Mobility Group Box Protein 1 Boosts Endothelial Albumin Transcytosis through the RAGE/Src/Caveolin-1 Pathway. PubMed ID: 27572515

Receptor for advanced glycation end products is targeted by FBXO10 for ubiquitination and degradation. PubMed ID: 28515150

LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome. PubMed ID: 34743181

The 1.5 A crystal structure of human receptor for advanced glycation endproducts (RAGE) ectodomains reveals unique features determining ligand binding. PubMed ID: 20943659

Structural basis for ligand recognition and activation of RAGE. PubMed ID: 20947022

Advanced glycation end product recognition by the receptor for AGEs. PubMed ID: 21565706

RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA. PubMed ID: 24081950