Gene AGER - ENSG00000204305 | NCBI Gene ID: 177

Details for: AGER

Gene ID: 177

Symbol: AGER

Ensembl ID: ENSG00000204305

Description: advanced glycosylation end-product specific receptor

Associated with

Advanced glycosylation endproduct receptor signaling
(R-HSA-879415)
Cytokine signaling in immune system
(R-HSA-1280215)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-HSA-168928)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Signaling by interleukins
(R-HSA-449147)
Tak1-dependent ikk and nf-kappa-b activation
(R-HSA-445989)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Traf6 mediated nf-kb activation
(R-HSA-933542)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Advanced glycation end-product receptor activity
(GO:0050785)
Amyloid-beta binding
(GO:0001540)
Apical plasma membrane
(GO:0016324)
Astrocyte activation
(GO:0048143)
Cell adhesion
(GO:0007155)
Cell junction
(GO:0030054)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to amyloid-beta
(GO:1904646)
Endocytosis
(GO:0006897)
Extracellular region
(GO:0005576)
Fibrillar center
(GO:0001650)
Glucose mediated signaling pathway
(GO:0010255)
Identical protein binding
(GO:0042802)
Induction of positive chemotaxis
(GO:0050930)
Inflammatory response
(GO:0006954)
Laminin receptor activity
(GO:0005055)
Learning or memory
(GO:0007611)
Microglial cell activation
(GO:0001774)
Molecular adaptor activity
(GO:0060090)
Negative regulation of blood circulation
(GO:1903523)
Negative regulation of interleukin-10 production
(GO:0032693)
Negative regulation of long-term synaptic depression
(GO:1900453)
Negative regulation of long-term synaptic potentiation
(GO:1900272)
Neuron projection development
(GO:0031175)
Plasma membrane
(GO:0005886)
Positive regulation of activated t cell proliferation
(GO:0042104)
Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
(GO:1902961)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of dendritic cell differentiation
(GO:2001200)
Positive regulation of endothelin production
(GO:1904472)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of heterotypic cell-cell adhesion
(GO:0034116)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of monocyte chemotactic protein-1 production
(GO:0071639)
Positive regulation of monocyte extravasation
(GO:2000439)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of non-canonical nf-kappab signal transduction
(GO:1901224)
Positive regulation of p38mapk cascade
(GO:1900745)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Postsynapse
(GO:0098794)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein localization to membrane
(GO:0072657)
Regulation of cd4-positive, alpha-beta t cell activation
(GO:2000514)
Regulation of inflammatory response
(GO:0050727)
Regulation of long-term synaptic potentiation
(GO:1900271)
Regulation of non-canonical nf-kappab signal transduction
(GO:1901222)
Regulation of p38mapk cascade
(GO:1900744)
Regulation of spontaneous synaptic transmission
(GO:0150003)
Regulation of synaptic plasticity
(GO:0048167)
Regulation of t cell mediated cytotoxicity
(GO:0001914)
Response to amyloid-beta
(GO:1904645)
Response to hypoxia
(GO:0001666)
Response to wounding
(GO:0009611)
S100 protein binding
(GO:0044548)
Scavenger receptor activity
(GO:0005044)
Signaling receptor activity
(GO:0038023)
Transcytosis
(GO:0045056)
Transmembrane signaling receptor activity
(GO:0004888)
Transport across blood-brain barrier
(GO:0150104)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: type I pneumocyte (CL0002062)
Fold Change: 5.55
Marker Score: 6689
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.78
Marker Score: 800
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 497
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 450
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5228
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2734
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.87
Marker Score: 314
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5280
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1263
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.78
Marker Score: 5065
Cell Name: pneumocyte (CL0000322)
Fold Change: 0.74
Marker Score: 1197
Cell Name: brush cell (CL0002204)
Fold Change: 0.73
Marker Score: 669
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.73
Marker Score: 557
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.68
Marker Score: 377
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.67
Marker Score: 267
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.66
Marker Score: 170
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.66
Marker Score: 2754
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.64
Marker Score: 5637
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.64
Marker Score: 3341
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 443
Cell Name: ionocyte (CL0005006)
Fold Change: 0.53
Marker Score: 161
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 0.45
Marker Score: 355
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.44
Marker Score: 1253
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.39
Marker Score: 260
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.34
Marker Score: 577
Cell Name: goblet cell (CL0000160)
Fold Change: 0.33
Marker Score: 2215
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.29
Marker Score: 114
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.29
Marker Score: 350
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.28
Marker Score: 391
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 0.28
Marker Score: 168
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 0.26
Marker Score: 132
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.26
Marker Score: 67
Cell Name: neutrophil (CL0000775)
Fold Change: 0.26
Marker Score: 156
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.24
Marker Score: 181
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.24
Marker Score: 69
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.23
Marker Score: 72
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.23
Marker Score: 1341.5
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 62
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.22
Marker Score: 12089
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.22
Marker Score: 146
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.21
Marker Score: 505
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.21
Marker Score: 106
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.21
Marker Score: 55
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.21
Marker Score: 70
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.2
Marker Score: 116
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.2
Marker Score: 63
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.2
Marker Score: 210
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.19
Marker Score: 137
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.19
Marker Score: 67
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.19
Marker Score: 79
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.19
Marker Score: 121
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.18
Marker Score: 172
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.18
Marker Score: 74
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.18
Marker Score: 753
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.17
Marker Score: 34
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.17
Marker Score: 1018
Cell Name: PP cell (CL0000696)
Fold Change: 0.17
Marker Score: 38
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.17
Marker Score: 38
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.17
Marker Score: 37
Cell Name: keratocyte (CL0002363)
Fold Change: 0.17
Marker Score: 38
Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 0.16
Marker Score: 37
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.16
Marker Score: 33
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.16
Marker Score: 108
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.16
Marker Score: 79
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 0.16
Marker Score: 39
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.16
Marker Score: 201
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.16
Marker Score: 73
Cell Name: mast cell (CL0000097)
Fold Change: 0.16
Marker Score: 92
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.16
Marker Score: 39
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: 0.16
Marker Score: 39
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 0.16
Marker Score: 39
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.16
Marker Score: 34
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.16
Marker Score: 46
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.16
Marker Score: 35
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.16
Marker Score: 65
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 0.16
Marker Score: 39
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.16
Marker Score: 34
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 0.15
Marker Score: 36
Cell Name: tendon cell (CL0000388)
Fold Change: 0.15
Marker Score: 38
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.15
Marker Score: 76
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.15
Marker Score: 85
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.15
Marker Score: 378
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.15
Marker Score: 57
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.15
Marker Score: 32
Cell Name: platelet (CL0000233)
Fold Change: 0.15
Marker Score: 68
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.15
Marker Score: 39
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.15
Marker Score: 39
Cell Name: leukocyte (CL0000738)
Fold Change: 0.15
Marker Score: 84
Cell Name: glomerular endothelial cell (CL0002188)
Fold Change: 0.15
Marker Score: 37
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.15
Marker Score: 144
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.14
Marker Score: 116
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 0.14
Marker Score: 38
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.14
Marker Score: 159
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 0.14
Marker Score: 38
Cell Name: muscle precursor cell (CL0000680)
Fold Change: 0.14
Marker Score: 37
Cell Name: vasa recta descending limb cell (CL1001285)
Fold Change: 0.14
Marker Score: 39
Cell Name: ILC1, human (CL0001077)
Fold Change: 0.14
Marker Score: 36
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 0.14
Marker Score: 31

Hover over a box to see details here...

**Key characteristics:** * AGER is a type I transmembrane receptor that is expressed on various cell types in the body. * It is a heterodimeric protein composed of two immunoglobulin heavy chains and two immunoglobulin light chains. * AGER is a key regulator of innate immunity and inflammation. * It is involved in the regulation of inflammation in response to infection and injury. **Pathways and functions:** * AGER is a key regulator of the innate immune response. * It is expressed on various cell types, including epithelial cells, macrophages, and dendritic cells. * AGER signaling is involved in the regulation of inflammation, cell migration, and differentiation. * It is also involved in the regulation of the immune response to pathogens. * AGER is a potential therapeutic target for inflammatory diseases. **Clinical significance:** * Mutations in the AGER gene have been linked to a number of human diseases, including rheumatoid arthritis, asthma, and inflammatory bowel disease. * AGER is a potential target for the treatment of inflammatory diseases. * The development of antibodies that block AGER signaling is a promising area of research for the treatment of inflammatory diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Advanced glycosylation end product-specific receptor
B4DNX3_HUMAN

Genular Protein ID: 1536672251

Symbol: RAGE_HUMAN

Name: Advanced glycosylation end product-specific receptor

UniProtKB Accession Codes:

Q15109 A2BFI7 A6NKF0 A7Y2U9 B0V176 Q15279 Q3L1R4 Q3L1R5 Q3L1R6 Q3L1R7 Q3L1R8 Q3L1S0 Q86SN1 Q9H2X7 Q9Y3R3 V5R6A3

Database IDs:

Citations:

PubMed ID: 1378843

Title: Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.

PubMed ID: 1378843

DOI: 10.1016/s0021-9258(18)42138-2

PubMed ID: 7835890

Title: Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3.

PubMed ID: 7835890

DOI: 10.1006/geno.1994.1517

PubMed ID: 12495433

Title: Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury.

PubMed ID: 12495433

DOI: 10.1042/bj20021371

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 18089847

Title: Identification, classification, and expression of RAGE gene splice variants.

PubMed ID: 18089847

DOI: 10.1096/fj.07-9909com

PubMed ID: 24260107

Title: Alternative splicing of the RAGE cytoplasmic domain regulates cell signaling and function.

PubMed ID: 24260107

DOI: 10.1371/journal.pone.0078267

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11375354

Title: Effects of novel polymorphisms in the RAGE gene on transcriptional regulation and their association with diabetic retinopathy.

PubMed ID: 11375354

DOI: 10.2337/diabetes.50.6.1505

PubMed ID: 19386136

Title: Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function.

PubMed ID: 19386136

DOI: 10.1186/1471-2091-10-11

PubMed ID: 19906677

Title: RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease.

PubMed ID: 19906677

DOI: 10.1096/fj.09-139634

PubMed ID: 21559403

Title: S100A14 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glycation end products (RAGE).

PubMed ID: 21559403

DOI: 10.1371/journal.pone.0019375

PubMed ID: 21829704

Title: TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding.

PubMed ID: 21829704

DOI: 10.1371/journal.pone.0023132

PubMed ID: 23284645

Title: Disulfide bonds within the C2 domain of RAGE play key roles in its dimerization and biogenesis.

PubMed ID: 23284645

DOI: 10.1371/journal.pone.0050736

PubMed ID: 27572515

Title: High Mobility Group Box Protein 1 Boosts Endothelial Albumin Transcytosis through the RAGE/Src/Caveolin-1 Pathway.

PubMed ID: 27572515

DOI: 10.1038/srep32180

PubMed ID: 28515150

Title: Receptor for advanced glycation end products is targeted by FBXO10 for ubiquitination and degradation.

PubMed ID: 28515150

DOI: 10.1096/fj.201700031r

PubMed ID: 34743181

Title: LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome.

PubMed ID: 34743181

DOI: 10.1038/s41420-021-00729-0

PubMed ID: 20943659

Title: The 1.5 A crystal structure of human receptor for advanced glycation endproducts (RAGE) ectodomains reveals unique features determining ligand binding.

PubMed ID: 20943659

DOI: 10.1074/jbc.m110.169276

PubMed ID: 20947022

Title: Structural basis for ligand recognition and activation of RAGE.

PubMed ID: 20947022

DOI: 10.1016/j.str.2010.05.017

PubMed ID: 21565706

Title: Advanced glycation end product recognition by the receptor for AGEs.

PubMed ID: 21565706

DOI: 10.1016/j.str.2011.02.013

PubMed ID: 24081950

Title: RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA.

PubMed ID: 24081950

DOI: 10.1084/jem.20120201

Sequence Information:

Length: 404
Mass: 42803
Checksum: 0D584C436C30CCE7
Sequence:

MAAGTAVGAW VLVLSLWGAV VGAQNITARI GEPLVLKCKG APKKPPQRLE WKLNTGRTEA 
WKVLSPQGGG PWDSVARVLP NGSLFLPAVG IQDEGIFRCQ AMNRNGKETK SNYRVRVYQI 
PGKPEIVDSA SELTAGVPNK VGTCVSEGSY PAGTLSWHLD GKPLVPNEKG VSVKEQTRRH 
PETGLFTLQS ELMVTPARGG DPRPTFSCSF SPGLPRHRAL RTAPIQPRVW EPVPLEEVQL 
VVEPEGGAVA PGGTVTLTCE VPAQPSPQIH WMKDGVPLPL PPSPVLILPE IGPQDQGTYS 
CVATHSSHGP QESRAVSISI IEPGEEGPTA GSVGGSGLGT LALALGILGG LGTAALLIGV 
ILWQRRQRRG EERKAPENQE EEEERAELNQ SEEPEAGESS TGGP

Genular Protein ID: 3351442283

Symbol: B4DNX3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DNX3

Database IDs:

Sequence Information:

Length: 435
Mass: 45980
Checksum: 6FF01FC403107051
Sequence:

MGAGERVQAP PRAEATAGRG ADRARTLEGS RMAAGTAVGA WVLVLSLWGA VVGAQNITAR 
IGEPLVLKCK GAPKKPPQRL EWKLNTGRTE AWKVLSPQGG GPWDSVARVL PNGSLFLPAV 
GIQDEGIFRC QAMNRNGKET KSNYRVRVYQ IPGKPEIVDS ASELTAGVPN KVGTCVSEGS 
YPAGTLSWHL DGKPLVPNEK GVSVKEQTRR HPETGLFTLQ SELMVTPARG GDPRPTFSCS 
FSPGLPRHRA LRTAPIQPRV WEPVPLEEVQ LVVEPEGGAV APGGTVTLTC EVPAQPSPQI 
HWMKDGVPLP LPPSPVLILP EIGPQDQGTY SCVATHSSHG PQESRAVSIS IIEPGEEGPT 
AGSVGGSGLG TLALALGILG GLGTAALLIG VILWQRRQRR GEERKAPENQ EEEEERAELN 
QSEEPEAGES STGGP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: AGER

Associated with

Cells (max top 100)

Other Information

Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. PubMed ID: 1378843

Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3. PubMed ID: 7835890

Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury. PubMed ID: 12495433

Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. PubMed ID: 14656967

Identification, classification, and expression of RAGE gene splice variants. PubMed ID: 18089847

Alternative splicing of the RAGE cytoplasmic domain regulates cell signaling and function. PubMed ID: 24260107

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Effects of novel polymorphisms in the RAGE gene on transcriptional regulation and their association with diabetic retinopathy. PubMed ID: 11375354

Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function. PubMed ID: 19386136

RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease. PubMed ID: 19906677

S100A14 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glycation end products (RAGE). PubMed ID: 21559403

TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding. PubMed ID: 21829704

Disulfide bonds within the C2 domain of RAGE play key roles in its dimerization and biogenesis. PubMed ID: 23284645

High Mobility Group Box Protein 1 Boosts Endothelial Albumin Transcytosis through the RAGE/Src/Caveolin-1 Pathway. PubMed ID: 27572515

Receptor for advanced glycation end products is targeted by FBXO10 for ubiquitination and degradation. PubMed ID: 28515150

LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome. PubMed ID: 34743181

The 1.5 A crystal structure of human receptor for advanced glycation endproducts (RAGE) ectodomains reveals unique features determining ligand binding. PubMed ID: 20943659

Structural basis for ligand recognition and activation of RAGE. PubMed ID: 20947022

Advanced glycation end product recognition by the receptor for AGEs. PubMed ID: 21565706

RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA. PubMed ID: 24081950