Details for: Mstn

Gene ID: 17700

Symbol: Mstn

Ensembl ID: ENSMUSG00000026100

Description: myostatin

Associated with

  • Cellular response to dexamethasone stimulus
    (GO:0071549)
  • Cytokine activity
    (GO:0005125)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Growth factor activity
    (GO:0008083)
  • Heparin binding
    (GO:0008201)
  • Identical protein binding
    (GO:0042802)
  • Muscle cell cellular homeostasis
    (GO:0046716)
  • Myoblast migration involved in skeletal muscle regeneration
    (GO:0014839)
  • Negative regulation of insulin receptor signaling pathway
    (GO:0046627)
  • Negative regulation of kinase activity
    (GO:0033673)
  • Negative regulation of muscle hypertrophy
    (GO:0014741)
  • Negative regulation of myoblast differentiation
    (GO:0045662)
  • Negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051898)
  • Negative regulation of skeletal muscle tissue growth
    (GO:0048632)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of lamellipodium assembly
    (GO:0010592)
  • Positive regulation of macrophage chemotaxis
    (GO:0010759)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Signaling receptor binding
    (GO:0005102)
  • Skeletal muscle satellite cell differentiation
    (GO:0014816)
  • Skeletal muscle tissue regeneration
    (GO:0043403)
  • Transforming growth factor beta receptor signaling pathway
    (GO:0007179)

Other Information

Genular Protein ID: 249699502

Symbol: GDF8_MOUSE

Name: Growth/differentiation factor 8

UniProtKB Accession Codes:

O08689

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChEMBL 1 DNASU 1 EMBL 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 2 GeneTree 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MGI 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 3 PRO 1 PROSITE 2 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 9139826

Title: Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member.

PubMed ID: 9139826

DOI: 10.1038/387083a0

PubMed ID: 12595574

Title: Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains.

PubMed ID: 12595574

DOI: 10.1210/me.2002-0366

PubMed ID: 14671324

Title: Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinases.

PubMed ID: 14671324

DOI: 10.1073/pnas.2534946100

PubMed ID: 24076600

Title: BMP signaling controls muscle mass.

PubMed ID: 24076600

DOI: 10.1038/ng.2772

PubMed ID: 19644449

Title: The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding.

PubMed ID: 19644449

DOI: 10.1038/emboj.2009.205

PubMed ID: 22052913

Title: Structure of myostatin.follistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding.

PubMed ID: 22052913

DOI: 10.1074/jbc.m111.270801

Sequence Information:

  • Length: 376
  • Mass: 42921
  • Checksum: 3E19814DD62C08BE
  • Sequence:
    • MMQKLQMYVY IYLFMLIAAG PVDLNEGSER EENVEKEGLC NACAWRQNTR YSRIEAIKIQ 
ILSKLRLETA PNISKDAIRQ LLPRAPPLRE LIDQYDVQRD DSSDGSLEDD DYHATTETII 
TMPTESDFLM QADGKPKCCF FKFSSKIQYN KVVKAQLWIY LRPVKTPTTV FVQILRLIKP 
MKDGTRYTGI RSLKLDMSPG TGIWQSIDVK TVLQNWLKQP ESNLGIEIKA LDENGHDLAV 
TFPGPGEDGL NPFLEVKVTD TPKRSRRDFG LDCDEHSTES RCCRYPLTVD FEAFGWDWII 
APKRYKANYC SGECEFVFLQ KYPHTHLVHQ ANPRGSAGPC CTPTKMSPIN MLYFNGKEQI 
IYGKIPAMVV DRCGCS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.