Genular: Defining Cellular Identity and Function

Details for: Msx2

Gene ID: 17702

Symbol: Msx2

Ensembl ID: ENSMUSG00000021469

Description: msh homeobox 2

Associated with

Activation of meiosis
(GO:0090427)
Anagen
(GO:0042640)
Anterior/posterior pattern specification
(GO:0009952)
Bmp signaling pathway
(GO:0030509)
Bone morphogenesis
(GO:0060349)
Bone trabecula formation
(GO:0060346)
Branching involved in mammary gland duct morphogenesis
(GO:0060444)
Cartilage development
(GO:0051216)
Catagen
(GO:0042637)
Cell surface receptor signaling pathway involved in heart development
(GO:0061311)
Cellular response to estradiol stimulus
(GO:0071392)
Cellular response to growth factor stimulus
(GO:0071363)
Chondrocyte development
(GO:0002063)
Cytosol
(GO:0005829)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Embryonic digit morphogenesis
(GO:0042733)
Embryonic forelimb morphogenesis
(GO:0035115)
Embryonic hindlimb morphogenesis
(GO:0035116)
Embryonic limb morphogenesis
(GO:0030326)
Embryonic morphogenesis
(GO:0048598)
Embryonic nail plate morphogenesis
(GO:0035880)
Enamel mineralization
(GO:0070166)
Endochondral bone growth
(GO:0003416)
Epithelial to mesenchymal transition involved in endocardial cushion formation
(GO:0003198)
Frontal suture morphogenesis
(GO:0060364)
Mammary gland epithelium development
(GO:0061180)
Mesenchymal cell apoptotic process
(GO:0097152)
Multicellular organism development
(GO:0007275)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of creb transcription factor activity
(GO:0032792)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of fat cell differentiation
(GO:0045599)
Negative regulation of keratinocyte differentiation
(GO:0045617)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of transcription regulatory region dna binding
(GO:2000678)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Odontogenesis
(GO:0042476)
Ossification
(GO:0001503)
Osteoblast development
(GO:0002076)
Osteoblast differentiation
(GO:0001649)
Outflow tract morphogenesis
(GO:0003151)
Outflow tract septum morphogenesis
(GO:0003148)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of bmp signaling pathway
(GO:0030513)
Positive regulation of mesenchymal cell apoptotic process
(GO:2001055)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of timing of catagen
(GO:0051795)
Protein binding
(GO:0005515)
Regulation of apoptotic process
(GO:0042981)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Signal transduction involved in regulation of gene expression
(GO:0023019)
Stem cell differentiation
(GO:0048863)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription factor binding
(GO:0008134)
Transcription regulator complex
(GO:0005667)
Wound healing
(GO:0042060)
Wound healing, spreading of epidermal cells
(GO:0035313)

Other Information

Proteins

Homeobox protein MSX-2

Genular Protein ID: 1316224537

Symbol: MSX2_MOUSE

Name: Homeobox protein MSX-2

UniProtKB Accession Codes:

Q03358 Q63856

Database IDs:

Citations:

PubMed ID: 1682128

Title: The Msh-like homeobox genes define domains in the developing vertebrate eye.

PubMed ID: 1682128

DOI: 10.1242/dev.112.4.1053

PubMed ID: 8098007

Title: Genomic structure, chromosomal location, and evolution of the mouse Hox 8 gene.

PubMed ID: 8098007

DOI: 10.1006/geno.1993.1149

PubMed ID: 1673109

Title: Cloning and evolutionary analysis of msh-like homeobox genes from mouse, zebrafish and ascidian.

PubMed ID: 1673109

DOI: 10.1016/0378-1119(91)90182-b

PubMed ID: 1677742

Title: Position-dependent expression of two related homeobox genes in developing vertebrate limbs.

PubMed ID: 1677742

DOI: 10.1038/352429a0

PubMed ID: 10451362

Title: The RRM domain of MINT, a novel msx2 binding protein, recognizes and regulates the rat osteocalcin promoter.

PubMed ID: 10451362

DOI: 10.1021/bi990967j

PubMed ID: 15383550

Title: Bone morphogenetic protein-2-induced alkaline phosphatase expression is stimulated by Dlx5 and repressed by Msx2.

PubMed ID: 15383550

DOI: 10.1074/jbc.m404145200

Sequence Information:

Length: 267
Mass: 28915
Checksum: F2F4528D6E9C951E
Sequence:

MASPTKGGDL FSSDEEGPAV LAGPGPGPGG AEGSAEERRV KVSSLPFSVE ALMSDKKPPK 
ESPAVPPDCA SAGAVLRPLL LPGHGVRDAH SPGPLVKPFE TASVKSENSE DGAPWIQEPG 
RYSPPPRHMS PTTCTLRKHK TNRKPRTPFT TSQLLALERK FRQKQYLSIA ERAEFSSSLN 
LTETQVKIWF QNRRAKAKRL QEAELEKLKM AAKPMLPSGF SLPFPINSPL QAASIYGASY 
PFHRPVLPIP PVGLYATPVG YGMYHLS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Msx2

Associated with

Other Information

The Msh-like homeobox genes define domains in the developing vertebrate eye. PubMed ID: 1682128

Genomic structure, chromosomal location, and evolution of the mouse Hox 8 gene. PubMed ID: 8098007

Cloning and evolutionary analysis of msh-like homeobox genes from mouse, zebrafish and ascidian. PubMed ID: 1673109

Position-dependent expression of two related homeobox genes in developing vertebrate limbs. PubMed ID: 1677742

The RRM domain of MINT, a novel msx2 binding protein, recognizes and regulates the rat osteocalcin promoter. PubMed ID: 10451362