Genular: Defining Cellular Identity and Function

Details for: Mtf2

Gene ID: 17765

Symbol: Mtf2

Ensembl ID: ENSMUSG00000029267

Description: metal response element binding transcription factor 2

Associated with

Gene expression (transcription)
(R-MMU-74160)
Prc2 methylates histones and dna
(R-MMU-212300)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Chromatin binding
(GO:0003682)
Chromatin organization
(GO:0006325)
Cytoplasm
(GO:0005737)
Dna binding
(GO:0003677)
Epigenetic regulation of gene expression
(GO:0040029)
Esc/e(z) complex
(GO:0035098)
Metal ion binding
(GO:0046872)
Methylated histone binding
(GO:0035064)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription
(GO:0006355)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Segment specification
(GO:0007379)
Stem cell differentiation
(GO:0048863)
Stem cell population maintenance
(GO:0019827)
Transcription corepressor binding
(GO:0001222)

Other Information

Proteins

Metal-response element-binding transcription factor 2

Genular Protein ID: 3993356282

Symbol: MTF2_MOUSE

Name: Metal-response element-binding transcription factor 2

UniProtKB Accession Codes:

Q02395 Q05C61 Q569Z8 Q6PG89 Q8BGP9 Q8BSJ7

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7772254

Title: Isolation of a cDNA encoding a metal response element binding protein using a novel expression cloning procedure: the one hybrid system.

PubMed ID: 7772254

DOI: 10.1089/dna.1994.13.731

PubMed ID: 9173905

Title: Interactions of the zinc-regulated factor (ZiRF1) with the mouse metallothionein Ia promoter.

PubMed ID: 9173905

DOI: 10.1042/bj3230079

PubMed ID: 20144788

Title: Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation.

PubMed ID: 20144788

DOI: 10.1016/j.stem.2009.12.014

PubMed ID: 21367819

Title: Polycomblike 2 facilitates the recruitment of PRC2 Polycomb group complexes to the inactive X chromosome and to target loci in embryonic stem cells.

PubMed ID: 21367819

DOI: 10.1242/dev.053652

PubMed ID: 21059868

Title: Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes.

PubMed ID: 21059868

DOI: 10.1128/mcb.00259-10

PubMed ID: 23104054

Title: Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity.

PubMed ID: 23104054

DOI: 10.1038/nsmb.2434

PubMed ID: 22438827

Title: Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal.

PubMed ID: 22438827

DOI: 10.1371/journal.pgen.1002576

Sequence Information:

Length: 593
Mass: 66924
Checksum: C595438196DC3E0F
Sequence:

MRDSTGAGNS LVHKRSPLRR NQKTSASLNK LSLQDGHKAK KPACKFEEGQ DVLARWSDGL 
FYLGTIKKIN ILKQSCFIIF EDSSKSWVLW KDIQTGATGS GEMVCTICQE EYSEAPNEMV 
ICDKCGQGYH QLCHTPHIDS SVIDSDEKWL CRQCVFATTT KRGGALKKGP NAKALQVMKQ 
TLPYSVADLE WDAGHKTNVQ QCYCYCGGPG DWYLKMLQCC KCKQWFHEAC VQCLQKPMLF 
GDRFYTFICS VCSSGPEYLK RLPLQWVDIA HLCLYNLSVI HKKKYFDSEL ELMTYINENW 
DRLHPGELAD TPKSERYEHV LEALNDYKTM FMSGKEIKKK KHLFGLRIRV PPVPPNVAFK 
AEKEPEGTSH EFKIKGRKAS KPTSDSREVS NGIEKKGKKK SVGRPPGPYT RKMIQKTAEL 
PLDKESVSEN PTLDLPCSIG RTEGIAHSSN TSDVDLTGAS SANETTSASI SRHCGLSDSR 
KRTRTGRSWP AAIPHLRRRR GRLPRRALQT QNSEVVKDDE GKEDYQFEEL NTEILNNLAD 
QELQLNHLKN SITSYFGAAG RIACGEKYRV LARRVTLDGK VQYLVEWEGA TAS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mtf2

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Isolation of a cDNA encoding a metal response element binding protein using a novel expression cloning procedure: the one hybrid system. PubMed ID: 7772254

Interactions of the zinc-regulated factor (ZiRF1) with the mouse metallothionein Ia promoter. PubMed ID: 9173905

Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation. PubMed ID: 20144788

Polycomblike 2 facilitates the recruitment of PRC2 Polycomb group complexes to the inactive X chromosome and to target loci in embryonic stem cells. PubMed ID: 21367819

Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes. PubMed ID: 21059868

Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. PubMed ID: 23104054

Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal. PubMed ID: 22438827