Details for: AGL
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 212.3498
Cell Significance Index: -33.0300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 126.9105
Cell Significance Index: -32.1900 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 73.4873
Cell Significance Index: -34.7000 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 72.1710
Cell Significance Index: -29.3200 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 30.7936
Cell Significance Index: -29.4000 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 27.4462
Cell Significance Index: -33.8400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 12.6733
Cell Significance Index: -33.9500 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 10.0148
Cell Significance Index: -30.7600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.6264
Cell Significance Index: -34.0400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 3.4099
Cell Significance Index: 87.6500 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 2.9743
Cell Significance Index: 72.5700 - Cell Name: type II muscle cell (CL0002212)
Fold Change: 2.6157
Cell Significance Index: 42.2100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.7745
Cell Significance Index: 319.8900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.6358
Cell Significance Index: 125.5300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.3166
Cell Significance Index: 153.4300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.3021
Cell Significance Index: 261.2000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.2904
Cell Significance Index: 158.6700 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.2837
Cell Significance Index: 27.4400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.2698
Cell Significance Index: 138.1200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.1257
Cell Significance Index: 67.5800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.0618
Cell Significance Index: 172.6900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.9292
Cell Significance Index: 24.8100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.8932
Cell Significance Index: 320.3600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8704
Cell Significance Index: 172.7400 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.8495
Cell Significance Index: 14.3100 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.8193
Cell Significance Index: 15.9900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.7171
Cell Significance Index: 32.5100 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6975
Cell Significance Index: 629.8300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.6586
Cell Significance Index: 45.5500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.5913
Cell Significance Index: 408.9800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.5461
Cell Significance Index: 30.6400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.5342
Cell Significance Index: 27.7500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.5180
Cell Significance Index: 31.8400 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.4714
Cell Significance Index: 6.9600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.4657
Cell Significance Index: 20.6000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.4577
Cell Significance Index: 12.2700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.4544
Cell Significance Index: 12.7000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4311
Cell Significance Index: 9.3400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.3792
Cell Significance Index: 14.3600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.3488
Cell Significance Index: 8.7200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3459
Cell Significance Index: 9.9700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.3106
Cell Significance Index: 14.4800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3101
Cell Significance Index: 169.3600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2600
Cell Significance Index: 49.4800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2222
Cell Significance Index: 30.5200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2125
Cell Significance Index: 13.4000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.2033
Cell Significance Index: 10.5900 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1856
Cell Significance Index: 18.3600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1833
Cell Significance Index: 81.0200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1704
Cell Significance Index: 77.3500 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.1472
Cell Significance Index: 3.5300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1161
Cell Significance Index: 218.5800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1119
Cell Significance Index: 71.0900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0918
Cell Significance Index: 10.8300 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.0688
Cell Significance Index: 0.9800 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.0545
Cell Significance Index: 0.6500 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0543
Cell Significance Index: 0.9300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0507
Cell Significance Index: 1.7800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0349
Cell Significance Index: 53.7300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0326
Cell Significance Index: 60.0400 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0320
Cell Significance Index: 0.8700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0291
Cell Significance Index: 21.3600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0212
Cell Significance Index: 3.6300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0109
Cell Significance Index: 1.5900 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0056
Cell Significance Index: 7.5700 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0013
Cell Significance Index: -0.1700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0093
Cell Significance Index: -5.8100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0165
Cell Significance Index: -12.2000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0174
Cell Significance Index: -0.3700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0245
Cell Significance Index: -18.5800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0353
Cell Significance Index: -19.9200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0388
Cell Significance Index: -2.6100 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.0610
Cell Significance Index: -0.9000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1016
Cell Significance Index: -21.4100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1017
Cell Significance Index: -29.2500 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: -0.1080
Cell Significance Index: -1.3600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1097
Cell Significance Index: -11.2100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1322
Cell Significance Index: -15.0900 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1501
Cell Significance Index: -3.9500 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1649
Cell Significance Index: -2.2500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1787
Cell Significance Index: -12.6400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1813
Cell Significance Index: -9.5200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1821
Cell Significance Index: -8.5600 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1919
Cell Significance Index: -24.7900 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.2097
Cell Significance Index: -10.6000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2117
Cell Significance Index: -24.2500 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.2194
Cell Significance Index: -2.0200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2283
Cell Significance Index: -23.7700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2677
Cell Significance Index: -19.9600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2993
Cell Significance Index: -19.3100 - Cell Name: Mueller cell (CL0000636)
Fold Change: -0.3081
Cell Significance Index: -2.3700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3226
Cell Significance Index: -25.5500 - Cell Name: peg cell (CL4033014)
Fold Change: -0.3580
Cell Significance Index: -8.2700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4024
Cell Significance Index: -24.6700 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.4895
Cell Significance Index: -10.3900 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.5025
Cell Significance Index: -14.3400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.5321
Cell Significance Index: -18.4900 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.5594
Cell Significance Index: -11.2300 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.5937
Cell Significance Index: -13.0000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.5987
Cell Significance Index: -10.0200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4040726575
Symbol: GDE_HUMAN
Name: Glycogen debranching enzyme
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1374391
Title: Molecular cloning and nucleotide sequence of cDNA encoding human muscle glycogen debranching enzyme.
PubMed ID: 1374391
PubMed ID: 8954797
Title: Human glycogen debranching enzyme gene (AGL): complete structural organization and characterization of the 5' flanking region.
PubMed ID: 8954797
PubMed ID: 9332391
Title: Isolation and nucleotide sequence of human liver glycogen debranching enzyme mRNA: identification of multiple tissue-specific isoforms.
PubMed ID: 9332391
PubMed ID: 10982190
Title: Heterogeneous mutations in the glycogen-debranching enzyme gene are responsible for glycogen storage disease type IIIa in Japan.
PubMed ID: 10982190
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17908927
Title: A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease.
PubMed ID: 17908927
DOI: 10.1101/gad.1553207
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 10571954
Title: Glycogen storage disease type IIIa: first report of a causative missense mutation (G1448R) of the glycogen debranching enzyme gene found in a homozygous patient.
PubMed ID: 10571954
DOI: 10.1002/(sici)1098-1004(199912)14:6<542::aid-humu15>3.0.co;2-0
Sequence Information:
- Length: 1532
- Mass: 174764
- Checksum: 9BF1BCC43B7904D3
- Sequence:
MGHSKQIRIL LLNEMEKLEK TLFRLEQGYE LQFRLGPTLQ GKAVTVYTNY PFPGETFNRE KFRSLDWENP TEREDDSDKY CKLNLQQSGS FQYYFLQGNE KSGGGYIVVD PILRVGADNH VLPLDCVTLQ TFLAKCLGPF DEWESRLRVA KESGYNMIHF TPLQTLGLSR SCYSLANQLE LNPDFSRPNR KYTWNDVGQL VEKLKKEWNV ICITDVVYNH TAANSKWIQE HPECAYNLVN SPHLKPAWVL DRALWRFSCD VAEGKYKEKG IPALIENDHH MNSIRKIIWE DIFPKLKLWE FFQVDVNKAV EQFRRLLTQE NRRVTKSDPN QHLTIIQDPE YRRFGCTVDM NIALTTFIPH DKGPAAIEEC CNWFHKRMEE LNSEKHRLIN YHQEQAVNCL LGNVFYERLA GHGPKLGPVT RKHPLVTRYF TFPFEEIDFS MEESMIHLPN KACFLMAHNG WVMGDDPLRN FAEPGSEVYL RRELICWGDS VKLRYGNKPE DCPYLWAHMK KYTEITATYF QGVRLDNCHS TPLHVAEYML DAARNLQPNL YVVAELFTGS EDLDNVFVTR LGISSLIREA MSAYNSHEEG RLVYRYGGEP VGSFVQPCLR PLMPAIAHAL FMDITHDNEC PIVHRSAYDA LPSTTIVSMA CCASGSTRGY DELVPHQISV VSEERFYTKW NPEALPSNTG EVNFQSGIIA ARCAISKLHQ ELGAKGFIQV YVDQVDEDIV AVTRHSPSIH QSVVAVSRTA FRNPKTSFYS KEVPQMCIPG KIEEVVLEAR TIERNTKPYR KDENSINGTP DITVEIREHI QLNESKIVKQ AGVATKGPNE YIQEIEFENL SPGSVIIFRV SLDPHAQVAV GILRNHLTQF SPHFKSGSLA VDNADPILKI PFASLASRLT LAELNQILYR CESEEKEDGG GCYDIPNWSA LKYAGLQGLM SVLAEIRPKN DLGHPFCNNL RSGDWMIDYV SNRLISRSGT IAEVGKWLQA MFFYLKQIPR YLIPCYFDAI LIGAYTTLLD TAWKQMSSFV QNGSTFVKHL SLGSVQLCGV GKFPSLPILS PALMDVPYRL NEITKEKEQC CVSLAAGLPH FSSGIFRCWG RDTFIALRGI LLITGRYVEA RNIILAFAGT LRHGLIPNLL GEGIYARYNC RDAVWWWLQC IQDYCKMVPN GLDILKCPVS RMYPTDDSAP LPAGTLDQPL FEVIQEAMQK HMQGIQFRER NAGPQIDRNM KDEGFNITAG VDEETGFVYG GNRFNCGTWM DKMGESDRAR NRGIPATPRD GSAVEIVGLS KSAVRWLLEL SKKNIFPYHE VTVKRHGKAI KVSYDEWNRK IQDNFEKLFH VSEDPSDLNE KHPNLVHKRG IYKDSYGASS PWCDYQLRPN FTIAMVVAPE LFTTEKAWKA LEIAEKKLLG PLGMKTLDPD DMVYCGIYDN ALDNDNYNLA KGFNYHQGPE WLWPIGYFLR AKLYFSRLMG PETTAKTIVL VKNVLSRHYV HLERSPWKGL PELTNENAQY CPFSCETQAW SIATILETLY DL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.