Details for: Mx1

Gene ID: 17857

Symbol: Mx1

Ensembl ID: ENSMUSG00000000386

Description: MX dynamin-like GTPase 1

Associated with

Other Information

Genular Protein ID: 1065183366

Symbol: MX1B_MOUSE

Name: Interferon-induced GTP-binding protein Mx1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3000619

Title: Mx protein: constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus.

PubMed ID: 3000619

DOI: 10.1016/0092-8674(86)90493-9

PubMed ID: 2974922

Title: Organization of the murine Mx gene and characterization of its interferon- and virus-inducible promoter.

PubMed ID: 2974922

DOI: 10.1128/mcb.8.8.3065-3079.1988

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2903437

Title: Influenza virus-susceptible mice carry Mx genes with a large deletion or a nonsense mutation.

PubMed ID: 2903437

DOI: 10.1128/mcb.8.10.4518-4523.1988

PubMed ID: 8411374

Title: A functional GTP-binding motif is necessary for antiviral activity of Mx proteins.

PubMed ID: 8411374

DOI: 10.1128/jvi.67.11.6726-6732.1993

PubMed ID: 17652381

Title: The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza viruses.

PubMed ID: 17652381

DOI: 10.1128/jvi.01116-07

PubMed ID: 18062906

Title: The Mx GTPase family of interferon-induced antiviral proteins.

PubMed ID: 18062906

DOI: 10.1016/j.micinf.2007.09.010

PubMed ID: 21859714

Title: Interferon-induced antiviral protein MxA interacts with the cellular RNA helicases UAP56 and URH49.

PubMed ID: 21859714

DOI: 10.1074/jbc.m111.251843

PubMed ID: 21651940

Title: Efficient influenza B virus propagation due to deficient interferon-induced antiviral activity in MDCK cells.

PubMed ID: 21651940

DOI: 10.1016/j.vaccine.2011.05.069

PubMed ID: 22190720

Title: Molecular signatures associated with Mx1-mediated resistance to highly pathogenic influenza virus infection: mechanisms of survival.

PubMed ID: 22190720

DOI: 10.1128/jvi.06156-11

Sequence Information:

  • Length: 631
  • Mass: 72038
  • Checksum: 7F0827668D190D68
  • Sequence:
  • MDSVNNLCRH YEEKVRPCID LIDTLRALGV EQDLALPAIA VIGDQSSGKS SVLEALSGVA 
    LPRGSGIVTR CPLVLKLRKL KEGEEWRGKV SYDDIEVELS DPSEVEEAIN KGQNFIAGVG 
    LGISDKLISL DVSSPNVPDL TLIDLPGITR VAVGNQPADI GRQIKRLIKT YIQKQETINL 
    VVVPSNVDIA TTEALSMAQE VDPEGDRTIG VLTKPDLVDR GAEGKVLDVM RNLVYPLKKG 
    YMIVKCRGQQ DIQEQLSLTE AFQKEQVFFK DHSYFSILLE DGKATVPCLA ERLTEELTSH 
    ICKSLPLLED QINSSHQSAS EELQKYGADI PEDDRTRMSF LVNKISAFNR NIMNLIQAQE 
    TVSEGDSRLF TKLRNEFLAW DDHIEEYFKK DSPEVQSKMK EFENQYRGRE LPGFVDYKAF 
    ESIIKKRVKA LEESAVNMLR RVTKMVQTAF VKILSNDFGD FLNLCCTAKS KIKEIRLNQE 
    KEAENLIRLH FQMEQIVYCQ DQVYKETLKT IREKEAEKEK TKALINPATF QNNSQFPQKG 
    LTTTEMTQHL KAYYQECRRN IGRQIPLIIQ YFILKTFGEE IEKMMLQLLQ DTSKCSWFLE 
    EQSDTREKKK FLKRRLLRLD EARQKLAKFS D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.