Details for: Myb

Gene ID: 17863

Symbol: Myb

Ensembl ID: ENSMUSG00000019982

Description: myeloblastosis oncogene

Associated with

  • B cell differentiation
    (GO:0030183)
  • Calcium ion transport
    (GO:0006816)
  • Cellular response to interleukin-6
    (GO:0071354)
  • Cellular response to leukemia inhibitory factor
    (GO:1990830)
  • Cytosol
    (GO:0005829)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Embryonic digestive tract development
    (GO:0048566)
  • Erythrocyte differentiation
    (GO:0030218)
  • G1/s transition of mitotic cell cycle
    (GO:0000082)
  • Homeostasis of number of cells
    (GO:0048872)
  • In utero embryonic development
    (GO:0001701)
  • Mitotic cell cycle
    (GO:0000278)
  • Myeloid cell development
    (GO:0061515)
  • Myeloid cell differentiation
    (GO:0030099)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of hematopoietic progenitor cell differentiation
    (GO:1901533)
  • Negative regulation of megakaryocyte differentiation
    (GO:0045653)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of collagen biosynthetic process
    (GO:0032967)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of glial cell proliferation
    (GO:0060252)
  • Positive regulation of hepatic stellate cell activation
    (GO:2000491)
  • Positive regulation of hepatic stellate cell proliferation
    (GO:1904899)
  • Positive regulation of mirna transcription
    (GO:1902895)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Positive regulation of smooth muscle cell proliferation
    (GO:0048661)
  • Positive regulation of testosterone secretion
    (GO:2000845)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of transforming growth factor beta production
    (GO:0071636)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of gene expression
    (GO:0010468)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulator complex
    (GO:0090575)
  • Spleen development
    (GO:0048536)
  • Stem cell division
    (GO:0017145)
  • T-helper 2 cell differentiation
    (GO:0045064)
  • Thymus development
    (GO:0048538)
  • Wd40-repeat domain binding
    (GO:0071987)

Other Information

Genular Protein ID: 1406709797

Symbol: MYB_MOUSE

Name: Transcriptional activator Myb

UniProtKB Accession Codes:

P06876 E9QMG8 Q61929

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ComplexPortal 1 DIP 1 DNASU 1 ELM 1 EMBL 16 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 43 Gene3D 1 GeneTree 1 Genevisible 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MGI 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 29 PDBsum 20 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 Pfam 3 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 3010282

Title: Murine myb protooncogene mRNA: cDNA sequence and evidence for 5' heterogeneity.

PubMed ID: 3010282

DOI: 10.1073/pnas.83.10.3204

PubMed ID: 2998780

Title: Nucleotide sequence of cDNA clones of the murine myb proto-oncogene.

PubMed ID: 2998780

DOI: 10.1002/j.1460-2075.1985.tb03884.x

PubMed ID: 3608990

Title: Multiple c-myb transcript cap sites are variously utilized in cells of mouse haemopoietic origin.

PubMed ID: 3608990

DOI: 10.1002/j.1460-2075.1987.tb02413.x

PubMed ID: 3033638

Title: Aberrant splicing events that are induced by proviral integration: implications for myb oncogene activation.

PubMed ID: 3033638

DOI: 10.1073/pnas.84.10.3171

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2481264

Title: Structure and biological activity of the transcriptional initiation sequences of the murine c-myb oncogene.

PubMed ID: 2481264

DOI: 10.1093/nar/17.23.9593

PubMed ID: 3023843

Title: Two modes of c-myb activation in virus-induced mouse myeloid tumors.

PubMed ID: 3023843

DOI: 10.1128/mcb.6.2.380-392.1986

PubMed ID: 3016644

Title: Structural organization and nucleotide sequence of mouse c-myb oncogene: activation in ABPL tumors is due to viral integration in an intron which results in the deletion of the 5' coding sequences.

PubMed ID: 3016644

DOI: 10.1093/nar/14.13.5309

PubMed ID: 3014527

Title: Truncation of the c-myb gene by a retroviral integration in an interleukin 3-dependent myeloid leukemia cell line.

PubMed ID: 3014527

DOI: 10.1073/pnas.83.14.5010

PubMed ID: 2670562

Title: Activation of c-myb by carboxy-terminal truncation: relationship to transformation of murine haemopoietic cells in vitro.

PubMed ID: 2670562

DOI: 10.1002/j.1460-2075.1989.tb03571.x

PubMed ID: 1923521

Title: Transformation by carboxyl-deleted Myb reflects increased transactivating capacity and disruption of a negative regulatory domain.

PubMed ID: 1923521

PubMed ID: 8408047

Title: Negative autoregulation of c-Myb activity by homodimer formation through the leucine zipper.

PubMed ID: 8408047

DOI: 10.1016/s0021-9258(20)80628-0

PubMed ID: 9447996

Title: Molecular cloning reveals that the p160 Myb-binding protein is a novel, predominantly nucleolar protein which may play a role in transactivation by Myb.

PubMed ID: 9447996

DOI: 10.1128/mcb.18.2.989

PubMed ID: 9566892

Title: c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation.

PubMed ID: 9566892

DOI: 10.1128/mcb.18.5.2729

PubMed ID: 15082531

Title: Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK.

PubMed ID: 15082531

DOI: 10.1101/gad.1170604

PubMed ID: 16162816

Title: TRAF7 sequesters c-Myb to the cytoplasm by stimulating its sumoylation.

PubMed ID: 16162816

DOI: 10.1091/mbc.e05-08-0731

PubMed ID: 17823980

Title: c-Maf interacts with c-Myb to down-regulate Bcl-2 expression and increase apoptosis in peripheral CD4 cells.

PubMed ID: 17823980

DOI: 10.1002/eji.200636979

PubMed ID: 1631139

Title: Solution structure of a DNA-binding unit of Myb: a helix-turn-helix-related motif with conserved tryptophans forming a hydrophobic core.

PubMed ID: 1631139

DOI: 10.1073/pnas.89.14.6428

PubMed ID: 8365401

Title: Secondary structure of the DNA-binding domain of the c-Myb oncoprotein in solution. A multidimensional double and triple heteronuclear NMR study.

PubMed ID: 8365401

DOI: 10.1111/j.1432-1033.1993.tb18126.x

PubMed ID: 7796266

Title: Comparison of the free and DNA-complexed forms of the DNA-binding domain from c-Myb.

PubMed ID: 7796266

DOI: 10.1038/nsb0495-309

PubMed ID: 8942977

Title: A small engineered protein lacks structural uniqueness by increasing the side-chain conformational entropy.

PubMed ID: 8942977

DOI: 10.1073/pnas.93.24.13583

PubMed ID: 11792321

Title: Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter.

PubMed ID: 11792321

DOI: 10.1016/s0092-8674(01)00636-5

Sequence Information:

  • Length: 636
  • Mass: 71422
  • Checksum: 0C6308E584726D01
  • Sequence:
    • MARRPRHSIY SSDEDDEDIE MCDHDYDGLL PKSGKRHLGK TRWTREEDEK LKKLVEQNGT 
DDWKVIANYL PNRTDVQCQH RWQKVLNPEL IKGPWTKEED QRVIELVQKY GPKRWSVIAK 
HLKGRIGKQC RERWHNHLNP EVKKTSWTEE EDRIIYQAHK RLGNRWAEIA KLLPGRTDNA 
IKNHWNSTMR RKVEQEGYLQ EPSKASQTPV ATSFQKNNHL MGFGHASPPS QLSPSGQSSV 
NSEYPYYHIA EAQNISSHVP YPVALHVNIV NVPQPAAAAI QRHYNDEDPE KEKRIKELEL 
LLMSTENELK GQQALPTQNH TCSYPGWHST SIVDQTRPHG DSAPVSCLGE HHATPSLPAD 
PGSLPEESAS PARCMIVHQG TILDNVKNLL EFAETLQFID SFLNTSSNHE SSGLDAPTLP 
STPLIGHKLT PCRDQTVKTQ KENSIFRTPA IKRSILESSP RTPTPFKHAL AAQEIKYGPL 
KMLPQTPSHA VEDLQDVIKQ ESDESGIVAE FQESGPPLLK KIKQEVESPT EKSGNFFCSN 
HWAENSLSTQ LFSQASPVAD APNILTSSVL MTPVSEDEDN VLKAFTVPKN RPLVGPLQPC 
SGAWEPASCG KTEDQMTASG PARKYVNAFS ARTLVM

Genular Protein ID: 229582150

Symbol: A0A087WPA7_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A087WPA7

Database IDs:

AGR 1 ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 23 Gene3D 1 GeneTree 1 InterPro 5 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 4 Pfam 3 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1 jPOST 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 755
  • Mass: 84179
  • Checksum: 5B98F01436480786
  • Sequence:
    • MARRPRHSIY SSDEDDEDIE MCDHDYDGLL PKSGKRHLGK TRWTREEDEK LKKLVEQNGT 
DDWKVIANYL PNRTDVQCQH RWQKVLNPEL IKGPWTKEED QRVIELVQKY GPKRWSVIAK 
HLKGRIGKQC RERWHNHLNP EVKKTSWTEE EDRIIYQAHK RLGNRWAEIA KLLPGRTDNA 
IKNHWNSTMR RKVEQEGYLQ EPSKASQTPV ATSFQKNNHL MGFGHASPPS QLSPSGQSSV 
NSEYPYYHIA EAQNISSHVP YPVALHVNIV NVPQPAAAAI QRHYNDEDPE KEKRIKELEL 
LLMSTENELK GQQALPTQNH TCSYPGWHST SIVDQTRPHG DSAPVSCLGE HHATPSLPAD 
PGSLPEESAS PARCMIVHQG TILDNVKNLL EFAETLQFID SDSSWCDLSS FEFSEEAAAF 
SPSQQPTGKA FQLQQREGHG TRSAGEPSLR VTRRVLSEAS LGPDSPQARH SKVPLVVLRK 
RRGQASPLAA GEPSPSLFAD VISSTLKRSP VKSLPFSPSQ FLNTSSNHES SGLDAPTLPS 
TPLIGHKLTP CRDQTVKTQK ENSIFRTPAI KRSILESSPR TPTPFKHALA AQEIKYGPLK 
MLPQTPSHAV EDLQDVIKQE SDESGIVAEF QESGPPLLKK IKQEVESPTE KSGNFFCSNH 
WAENSLSTQL FSQASPVADA PNILTSSVLM TPVSEDEDNV LKAFTVPKNR PLVGPLQPCS 
GAWEPASCGK TEDQMTASGP ARKYVNAFSA RTLVM

Genular Protein ID: 2056350493

Symbol: Q3UUX5_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UUX5

Database IDs:

AGR 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 Genevisible 1 InterPro 1 KEGG 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 Pfam 2 RefSeq 1 SAM 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 334
  • Mass: 36203
  • Checksum: 1E231A0FDFF5E7B0
  • Sequence:
    • MSTENELKGQ QALPTQNHTC SYPGWHSTSI VDQTRPHGDS APVSCLGEHH ATPSLPADPG 
SLPEESASPA RCMIVHQGTI LDNVKNLLEF AETLQFIDSF LNTSSNHESS GLDAPTLPST 
PLIGHKLTPC RDQTVKTQKE NSIFRTPAIK RSILESSPRT PTPFKHALAA QEIKYGPLKM 
LPQTPSHAVE DLQDVIKQES DESGIVAEFQ ESGPPLLKKI KQEVESPTEK SGNFFCSNHW 
AENSLSTQLF SQASPVADAP NILTSSVLMT PVSEDEDNVL KAFTVPKNRP LVGPLQPCSG 
AWEPASCGKT EDQMTASGPA RKYVNAFSAR TLVM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.