Details for: Myc

Gene ID: 17869

Symbol: Myc

Ensembl ID: ENSMUSG00000022346

Description: myelocytomatosis oncogene

Associated with

  • Deubiquitination
    (R-MMU-5688426)
  • Gene expression (transcription)
    (R-MMU-74160)
  • Generic transcription pathway
    (R-MMU-212436)
  • Metabolism of proteins
    (R-MMU-392499)
  • Post-translational protein modification
    (R-MMU-597592)
  • Rna polymerase ii transcription
    (R-MMU-73857)
  • Tfap2 (ap-2) family regulates transcription of cell cycle factors
    (R-MMU-8866911)
  • Transcriptional regulation by the ap-2 (tfap2) family of transcription factors
    (R-MMU-8864260)
  • Ub-specific processing proteases
    (R-MMU-5689880)
  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Amino acid transport
    (GO:0006865)
  • B cell apoptotic process
    (GO:0001783)
  • Branching involved in ureteric bud morphogenesis
    (GO:0001658)
  • Cell population proliferation
    (GO:0008283)
  • Cellular response to interferon-alpha
    (GO:0035457)
  • Chromatin remodeling
    (GO:0006338)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Core promoter sequence-specific dna binding
    (GO:0001046)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription factor binding
    (GO:0140297)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna-templated transcription
    (GO:0006351)
  • Dna-templated transcription initiation
    (GO:0006352)
  • Dna binding
    (GO:0003677)
  • Dna damage response
    (GO:0006974)
  • Dna methylation-dependent heterochromatin formation
    (GO:0006346)
  • Double-stranded dna binding
    (GO:0003690)
  • E-box binding
    (GO:0070888)
  • G1/s transition of mitotic cell cycle
    (GO:0000082)
  • Glucose metabolic process
    (GO:0006006)
  • Identical protein binding
    (GO:0042802)
  • Inner mitochondrial membrane organization
    (GO:0007007)
  • Intracellular iron ion homeostasis
    (GO:0006879)
  • Intrinsic apoptotic signaling pathway in response to dna damage
    (GO:0008630)
  • Lactic acid secretion
    (GO:0046722)
  • Mapk cascade
    (GO:0000165)
  • Middle ear morphogenesis
    (GO:0042474)
  • Myotube differentiation
    (GO:0014902)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of glucose import
    (GO:0046325)
  • Negative regulation of monocyte differentiation
    (GO:0045656)
  • Negative regulation of protein binding
    (GO:0032091)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nk t cell proliferation
    (GO:0001866)
  • Pigmentation
    (GO:0043473)
  • Positive regulation of b cell apoptotic process
    (GO:0002904)
  • Positive regulation of catalytic activity
    (GO:0043085)
  • Positive regulation of cell cycle
    (GO:0045787)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043280)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of glycolytic process
    (GO:0045821)
  • Positive regulation of mesenchymal cell proliferation
    (GO:0002053)
  • Positive regulation of mitochondrial membrane potential
    (GO:0010918)
  • Positive regulation of smooth muscle cell migration
    (GO:0014911)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein-containing complex binding
    (GO:0044877)
  • Protein-dna complex disassembly
    (GO:0032986)
  • Protein binding
    (GO:0005515)
  • Protein dimerization activity
    (GO:0046983)
  • Protein processing
    (GO:0016485)
  • Pyruvate transport
    (GO:0006848)
  • Re-entry into mitotic cell cycle
    (GO:0000320)
  • Regulation of apoptotic process
    (GO:0042981)
  • Regulation of cell cycle process
    (GO:0010564)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of mitotic cell cycle
    (GO:0007346)
  • Regulation of oxidative phosphorylation
    (GO:0002082)
  • Regulation of telomere maintenance
    (GO:0032204)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to alkaloid
    (GO:0043279)
  • Response to gamma radiation
    (GO:0010332)
  • Response to radiation
    (GO:0009314)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Scf ubiquitin ligase complex binding
    (GO:1905761)
  • Sequence-specific dna binding
    (GO:0043565)
  • Skeletal muscle cell differentiation
    (GO:0035914)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription coregulator binding
    (GO:0001221)
  • Ubiquitin protein ligase binding
    (GO:0031625)
  • Wnt signaling pathway
    (GO:0016055)

Other Information

Genular Protein ID: 2583293847

Symbol: MYC_MOUSE

Name: Myc proto-oncogene protein

UniProtKB Accession Codes:

P01108 A0A087WSQ0 B2RSN1 F6PX41 F8WID3 P70247 Q3UM70 Q61422

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DNASU 1 EMBL 10 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 100 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 2 RefSeq 4 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 6321164

Title: Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours.

PubMed ID: 6321164

DOI: 10.1002/j.1460-2075.1983.tb01749.x

PubMed ID: 6462227

Title: Nucleotide sequence comparison of normal and translocated murine c-myc genes.

PubMed ID: 6462227

DOI: 10.1038/310423a0

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6412145

Title: Reciprocal chromosome translocation between c-myc and immunoglobulin gamma 2b genes.

PubMed ID: 6412145

DOI: 10.1038/305240a0

PubMed ID: 3277717

Title: A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas.

PubMed ID: 3277717

DOI: 10.1016/0092-8674(88)90507-7

PubMed ID: 1628829

Title: Translational activation of the non-AUG-initiated c-myc 1 protein at high cell densities due to methionine deprivation.

PubMed ID: 1628829

DOI: 10.1101/gad.6.7.1229

PubMed ID: 8521822

Title: Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.

PubMed ID: 8521822

DOI: 10.1002/j.1460-2075.1995.tb00252.x

PubMed ID: 8617250

Title:

PubMed ID: 8617250

DOI: 10.1002/j.1460-2075.1996.tb00555.x

PubMed ID: 12391307

Title: JLP: a scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors.

PubMed ID: 12391307

DOI: 10.1073/pnas.232310199

PubMed ID: 16904174

Title: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

PubMed ID: 16904174

DOI: 10.1016/j.cell.2006.07.024

PubMed ID: 18438430

Title: Pim kinase-dependent inhibition of c-Myc degradation.

PubMed ID: 18438430

DOI: 10.1038/onc.2008.123

PubMed ID: 22510880

Title: Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation.

PubMed ID: 22510880

DOI: 10.1038/emboj.2012.91

PubMed ID: 22328504

Title: TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic stem cells.

PubMed ID: 22328504

DOI: 10.1242/jcs.095273

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 31005419

Title: TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network.

PubMed ID: 31005419

DOI: 10.1016/j.molcel.2019.03.025

Sequence Information:

  • Length: 454
  • Mass: 50678
  • Checksum: 1CE6F658565FF720
  • Sequence:
    • MDFLWALETP QTATTMPLNV NFTNRNYDLD YDSVQPYFIC DEEENFYHQQ QQSELQPPAP 
SEDIWKKFEL LPTPPLSPSR RSGLCSPSYV AVATSFSPRE DDDGGGGNFS TADQLEMMTE 
LLGGDMVNQS FICDPDDETF IKNIIIQDCM WSGFSAAAKL VSEKLASYQA ARKDSTSLSP 
ARGHSVCSTS SLYLQDLTAA ASECIDPSVV FPYPLNDSSS PKSCTSSDST AFSPSSDSLL 
SSESSPRASP EPLVLHEETP PTTSSDSEEE QEDEEEIDVV SVEKRQTPAK RSESGSSPSR 
GHSKPPHSPL VLKRCHVSTH QHNYAAPPST RKDYPAAKRA KLDSGRVLKQ ISNNRKCSSP 
RSSDTEENDK RRTHNVLERQ RRNELKRSFF ALRDQIPELE NNEKAPKVVI LKKATAYILS 
IQADEHKLTS EKDLLRKRRE QLKHKLEQLR NSGA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.