Details for: Ppp1r15a

Gene ID: 17872

Symbol: Ppp1r15a

Ensembl ID: ENSMUSG00000040435

Description: protein phosphatase 1, regulatory subunit 15A

Associated with

  • Apoptotic process
    (GO:0006915)
  • Cytoplasm
    (GO:0005737)
  • Endoplasmic reticulum
    (GO:0005783)
  • Endoplasmic reticulum membrane
    (GO:0005789)
  • Endoplasmic reticulum unfolded protein response
    (GO:0030968)
  • Golgi apparatus
    (GO:0005794)
  • Membrane
    (GO:0016020)
  • Mitochondrial outer membrane
    (GO:0005741)
  • Mitochondrion
    (GO:0005739)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of peptidyl-threonine phosphorylation
    (GO:0010801)
  • Negative regulation of phosphoprotein phosphatase activity
    (GO:0032515)
  • Negative regulation of protein dephosphorylation
    (GO:0035308)
  • Negative regulation of protein processing
    (GO:0010955)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of endoplasmic reticulum stress-induced eif2 alpha dephosphorylation
    (GO:1903917)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of peptidyl-serine dephosphorylation
    (GO:1902310)
  • Positive regulation of peptidyl-serine phosphorylation
    (GO:0033138)
  • Positive regulation of phosphoprotein phosphatase activity
    (GO:0032516)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of transcription by rna polymerase i
    (GO:0045943)
  • Protein kinase binding
    (GO:0019901)
  • Protein localization to endoplasmic reticulum
    (GO:0070972)
  • Protein phosphatase 1 binding
    (GO:0008157)
  • Protein phosphatase binding
    (GO:0019903)
  • Protein phosphatase regulator activity
    (GO:0019888)
  • Protein phosphatase type 1 complex
    (GO:0000164)
  • Regulation of angiogenesis
    (GO:0045765)
  • Regulation of endoplasmic reticulum stress-induced eif2 alpha phosphorylation
    (GO:0060734)
  • Regulation of translation
    (GO:0006417)
  • Regulation of translational initiation by eif2 alpha dephosphorylation
    (GO:0036496)
  • Response to endoplasmic reticulum stress
    (GO:0034976)

Other Information

Genular Protein ID: 2267075228

Symbol: PR15A_MOUSE

Name: Protein phosphatase 1 regulatory subunit 15A

UniProtKB Accession Codes:

P17564 Q3TJS6 Q3U3L5 Q8C579

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 33 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 1 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SAM 1 STRING 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 2339071

Title: Sequence of MyD116 cDNA: a novel myeloid differentiation primary response gene induced by IL6.

PubMed ID: 2339071

DOI: 10.1093/nar/18.9.2823

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 8139541

Title: The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.

PubMed ID: 8139541

DOI: 10.1128/mcb.14.4.2361-2371.1994

PubMed ID: 9371605

Title: The herpes simplex virus virulence factor ICP34.5 and the cellular protein MyD116 complex with proliferating cell nuclear antigen through the 63-amino-acid domain conserved in ICP34.5, MyD116, and GADD34.

PubMed ID: 9371605

DOI: 10.1128/jvi.71.12.9442-9449.1997

PubMed ID: 9023344

Title: The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase.

PubMed ID: 9023344

DOI: 10.1073/pnas.94.3.843

PubMed ID: 11381086

Title: Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha.

PubMed ID: 11381086

DOI: 10.1083/jcb.153.5.1011

PubMed ID: 11517336

Title: Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis.

PubMed ID: 11517336

DOI: 10.1073/pnas.191130798

PubMed ID: 12606582

Title: Stress-induced gene expression requires programmed recovery from translational repression.

PubMed ID: 12606582

DOI: 10.1093/emboj/cdg112

PubMed ID: 12824288

Title: The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice.

PubMed ID: 12824288

DOI: 10.1096/fj.02-1184fje

PubMed ID: 16478986

Title: Gadd34 requirement for normal hemoglobin synthesis.

PubMed ID: 16478986

DOI: 10.1128/mcb.26.5.1644-1653.2006

PubMed ID: 17670836

Title: Suppression of viral replication by stress-inducible GADD34 protein via the mammalian serine/threonine protein kinase mTOR pathway.

PubMed ID: 17670836

DOI: 10.1128/jvi.01063-07

PubMed ID: 19131336

Title: An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation.

PubMed ID: 19131336

DOI: 10.1074/jbc.m806735200

Sequence Information:

  • Length: 657
  • Mass: 71840
  • Checksum: 9B217001019C38A7
  • Sequence:
    • MAPSPRPQHV LHWRDAHNFY LLSPLMGLLS RAWSRLRGPE VPEAWLAKTV TGADQIEAAA 
LLTPTPVSGN LLPHGETEES GSPEQSQAAQ RLCLVEAESS PPETWGLSNV DEYNAKPGQD 
DLREKEMERT AGKATLQPAG LQGADKRLGE VVAREEGVAE PAYPTSQLEG GPAENEEDGE 
TVKTYQASAA SIAPGYKPST PVPFLGEAEH QATEEKGTEN KADPSNSPSS GSHSRAWEYY 
SREKPKQEGE AKVEAHRAGQ GHPCRNAEAE EGGPETTFVC TGNAFLKAWV YRPGEDTEEE 
DNSDSDSAEE DTAQTGATPH TSAFLKAWVY RPGEDTEEED SDSDSAEEDT AQTGATPHTS 
AFLKAWVYRP GEDTEEENSD LDSAEEDTAQ TGATPHTSAF LKAWVYRPGE DTEEENSDLD 
SAEEDTAQTG ATPHTSPFLK AWVYRPGEDT EDDTEEEEDS ENVAPGDSET ADSSQSPCLQ 
PQRCLPGEKT KGRGEEPPLF QVAFYLPGEK PESPWAAPKL PLRLQRRLRL FKAPTRDQDP 
EIPLKARKVH FAEKVTVHFL AVWAGPAQAA RRGPWEQFAR DRSRFARRIA QAEEKLGPYL 
TPDSRARAWA RLRNPSLPQS EPRSSSEATP LTQDVTTPSP LPSETPSPSL YLGGRRG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.