Genular: Defining Cellular Identity and Function

Details for: Myd88

Gene ID: 17874

Symbol: Myd88

Ensembl ID: ENSMUSG00000032508

Description: myeloid differentiation primary response gene 88

Associated with

Cytokine signaling in immune system
(R-MMU-1280215)
Cytosolic sensors of pathogen-associated dna
(R-MMU-1834949)
Death receptor signaling
(R-MMU-73887)
Dex/h-box helicases activate type i ifn and inflammatory cytokines production
(R-MMU-3134963)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-1 family signaling
(R-MMU-446652)
Interleukin-1 signaling
(R-MMU-9020702)
Intracellular signaling by second messengers
(R-MMU-9006925)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
P75 ntr receptor-mediated signalling
(R-MMU-193704)
P75ntr recruits signalling complexes
(R-MMU-209543)
P75ntr signals via nf-kb
(R-MMU-193639)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Rip-mediated nfkb activation via zbp1
(R-MMU-1810476)
Signaling by interleukins
(R-MMU-449147)
Zbp1(dai) mediated induction of type i ifns
(R-MMU-1606322)
Apoptotic process
(GO:0006915)
Atp-dependent histone chaperone activity
(GO:0140674)
Cell surface receptor signaling pathway
(GO:0007166)
Chemokine production
(GO:0032602)
Chromatin organization
(GO:0006325)
Cytokine-mediated signaling pathway
(GO:0019221)
Defense response to bacterium
(GO:0042742)
Defense response to gram-positive bacterium
(GO:0050830)
Defense response to protozoan
(GO:0042832)
Gene expression
(GO:0010467)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Immune system process
(GO:0002376)
Immunoglobulin mediated immune response
(GO:0016064)
Induced systemic resistance
(GO:0009682)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Interleukin-1 receptor binding
(GO:0005149)
Interleukin-6 production
(GO:0032635)
Interleukin-33-mediated signaling pathway
(GO:0038172)
Jnk cascade
(GO:0007254)
Leukocyte activation involved in inflammatory response
(GO:0002269)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Macrophage cytokine production
(GO:0010934)
Microglia differentiation
(GO:0014004)
Molecular adaptor activity
(GO:0060090)
Myd88-dependent toll-like receptor signaling pathway
(GO:0002755)
Neurogenesis
(GO:0022008)
Neutrophil activation involved in immune response
(GO:0002283)
Phagocytosis
(GO:0006909)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of interleukin-17 production
(GO:0032740)
Positive regulation of interleukin-23 production
(GO:0032747)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of lymphocyte proliferation
(GO:0050671)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of type i interferon production
(GO:0032481)
Protein binding
(GO:0005515)
Protein self-association
(GO:0043621)
Regulation of cell population proliferation
(GO:0042127)
Regulation of gene expression
(GO:0010468)
Regulation of inflammatory response
(GO:0050727)
Regulation of interleukin-6 production
(GO:0032675)
Regulation of tumor necrosis factor production
(GO:0032680)
Response to lipopolysaccharide
(GO:0032496)
Response to molecule of fungal origin
(GO:0002238)
Response to peptidoglycan
(GO:0032494)
Response to virus
(GO:0009615)
Signaling adaptor activity
(GO:0035591)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Skin development
(GO:0043588)
Tir domain binding
(GO:0070976)
Toll-like receptor 4 signaling pathway
(GO:0034142)
Toll-like receptor 8 signaling pathway
(GO:0034158)
Toll-like receptor binding
(GO:0035325)
Toll binding
(GO:0005121)
Toll signaling pathway
(GO:0008063)
Transmembrane receptor protein serine/threonine kinase signaling pathway
(GO:0007178)
Tumor necrosis factor production
(GO:0032640)
Type i interferon production
(GO:0032606)

Other Information

Proteins

Myeloid differentiation primary response protein MyD88

Genular Protein ID: 963033625

Symbol: MYD88_MOUSE

Name: Myeloid differentiation primary response protein MyD88

UniProtKB Accession Codes:

P22366 O35916

Database IDs:

Citations:

PubMed ID: 9013863

Title: The cloning and characterization of human MyD88: a member of an IL-1 receptor related family.

PubMed ID: 9013863

DOI: 10.1016/s0014-5793(96)01506-2

PubMed ID: 9344657

Title: Genetic structure and chromosomal mapping of MyD88.

PubMed ID: 9344657

DOI: 10.1006/geno.1997.4940

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2374694

Title: Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6.

PubMed ID: 2374694

PubMed ID: 9575168

Title: MyD88, an adapter protein involved in interleukin-1 signaling.

PubMed ID: 9575168

DOI: 10.1074/jbc.273.20.12203

PubMed ID: 9697844

Title: Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.

PubMed ID: 9697844

DOI: 10.1016/s1074-7613(00)80596-8

PubMed ID: 11909531

Title: Regulation of interleukin-1- and lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88.

PubMed ID: 11909531

DOI: 10.1016/s0960-9822(02)00712-1

PubMed ID: 16951688

Title: Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adapter Pellino-1.

PubMed ID: 16951688

DOI: 10.1038/ni1383

PubMed ID: 17018642

Title: Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program.

PubMed ID: 17018642

DOI: 10.1073/pnas.0607181103

PubMed ID: 17635956

Title: MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection.

PubMed ID: 17635956

DOI: 10.1084/jem.20070563

PubMed ID: 18941239

Title: Signaling through MyD88 regulates leukocyte recruitment after brain injury.

PubMed ID: 18941239

DOI: 10.4049/jimmunol.181.9.6481

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21998396

Title: The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine.

PubMed ID: 21998396

DOI: 10.1126/science.1209791

PubMed ID: 22187460

Title: Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt.

PubMed ID: 22187460

DOI: 10.1073/pnas.1118579109

PubMed ID: 29395066

Title: OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signaling.

PubMed ID: 29395066

DOI: 10.1016/j.molcel.2018.01.009

Sequence Information:

Length: 296
Mass: 33753
Checksum: 393A75C3723FFE69
Sequence:

MSAGDPRVGS GSLDSFMFSI PLVALNVGVR RRLSLFLNPR TPVAADWTLL AEEMGFEYLE 
IRELETRPDP TRSLLDAWQG RSGASVGRLL ELLALLDRED ILKELKSRIE EDCQKYLGKQ 
QNQESEKPLQ VARVESSVPQ TKELGGITTL DDPLGQTPEL FDAFICYCPN DIEFVQEMIR 
QLEQTDYRLK LCVSDRDVLP GTCVWSIASE LIEKRCRRMV VVVSDDYLQS KECDFQTKFA 
LSLSPGVQQK RLIPIKYKAM KKDFPSILRF ITICDYTNPC TKSWFWTRLA KALSLP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Myd88

Associated with

Other Information

The cloning and characterization of human MyD88: a member of an IL-1 receptor related family. PubMed ID: 9013863

Genetic structure and chromosomal mapping of MyD88. PubMed ID: 9344657

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6. PubMed ID: 2374694

MyD88, an adapter protein involved in interleukin-1 signaling. PubMed ID: 9575168

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. PubMed ID: 9697844

Regulation of interleukin-1- and lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88. PubMed ID: 11909531

Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adapter Pellino-1. PubMed ID: 16951688

Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program. PubMed ID: 17018642

MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection. PubMed ID: 17635956

Signaling through MyD88 regulates leukocyte recruitment after brain injury. PubMed ID: 18941239

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. PubMed ID: 21998396

Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt. PubMed ID: 22187460

OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signaling. PubMed ID: 29395066