Genular: Defining Cellular Identity and Function

Details for: Myl2

Gene ID: 17906

Symbol: Myl2

Ensembl ID: ENSMUSG00000013936

Description: myosin, light polypeptide 2, regulatory, cardiac, slow

Associated with

Muscle contraction
(R-MMU-397014)
Striated muscle contraction
(R-MMU-390522)
Actin cytoskeleton
(GO:0015629)
Actin monomer binding
(GO:0003785)
Calcium ion binding
(GO:0005509)
Cardiac muscle contraction
(GO:0060048)
Cardiac myofibril
(GO:0097512)
Cardiac myofibril assembly
(GO:0055003)
Contractile fiber
(GO:0043292)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Heart contraction
(GO:0060047)
Heart development
(GO:0007507)
Heart morphogenesis
(GO:0003007)
Metal ion binding
(GO:0046872)
Muscle cell development
(GO:0055001)
Muscle cell fate specification
(GO:0042694)
Myofibril
(GO:0030016)
Myosin complex
(GO:0016459)
Negative regulation of cell growth
(GO:0030308)
Positive regulation of the force of heart contraction
(GO:0098735)
Post-embryonic development
(GO:0009791)
Regulation of the force of heart contraction
(GO:0002026)
Structural constituent of muscle
(GO:0008307)
Ventricular cardiac muscle tissue morphogenesis
(GO:0055010)

Other Information

Proteins

MLRV_MOUSE

Genular Protein ID: 2221482932

Symbol: MLRV_MOUSE

Name: N/A

UniProtKB Accession Codes:

P51667 Q6P8P4 Q9QVP3

Database IDs:

Citations:

PubMed ID: 1379240

Title: Myosin light chain-2 luciferase transgenic mice reveal distinct regulatory programs for cardiac and skeletal muscle-specific expression of a single contractile protein gene.

PubMed ID: 1379240

DOI: 10.1016/s0021-9258(19)49616-6

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8506363

Title: Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube.

PubMed ID: 8506363

DOI: 10.1073/pnas.90.11.5157

PubMed ID: 9422794

Title: Selective requirement of myosin light chain 2v in embryonic heart function.

PubMed ID: 9422794

DOI: 10.1074/jbc.273.2.1252

PubMed ID: 10409661

Title: Abnormal cardiac structure and function in mice expressing nonphosphorylatable cardiac regulatory myosin light chain 2.

PubMed ID: 10409661

DOI: 10.1074/jbc.274.30.21085

PubMed ID: 16908724

Title: Acceleration of stretch activation in murine myocardium due to phosphorylation of myosin regulatory light chain.

PubMed ID: 16908724

DOI: 10.1085/jgp.200609547

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20038585

Title: Cardiac myosin is a substrate for zipper-interacting protein kinase (ZIPK).

PubMed ID: 20038585

DOI: 10.1074/jbc.c109.076489

PubMed ID: 20445002

Title: A novel, in-solution separation of endogenous cardiac sarcomeric proteins and identification of distinct charged variants of regulatory light chain.

PubMed ID: 20445002

DOI: 10.1074/mcp.m110.000075

PubMed ID: 20668449

Title: NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.

PubMed ID: 20668449

DOI: 10.1038/nature09343

PubMed ID: 23095280

Title: Myosin light chain phosphorylation is critical for adaptation to cardiac stress.

PubMed ID: 23095280

DOI: 10.1161/circulationaha.112.116202

PubMed ID: 22426213

Title: Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease.

PubMed ID: 22426213

DOI: 10.1172/jci61134

Sequence Information:

Length: 166
Mass: 18864
Checksum: EA25C1FAA18E2EA8
Sequence:

MAPKKAKKRI EGGSSNVFSM FEQTQIQEFK EAFTIMDQNR DGFIDKNDLR DTFAALGRVN 
VKNEEIDEMI KEAPGPINFT VFLTMFGEKL KGADPEETIL NAFKVFDPEG KGSLKADYVR 
EMLTTQAERF SKEEIDQMFA AFPPDVTGNL DYKNLVHIIT HGEEKD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Myl2

Associated with

Other Information

Myosin light chain-2 luciferase transgenic mice reveal distinct regulatory programs for cardiac and skeletal muscle-specific expression of a single contractile protein gene. PubMed ID: 1379240

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube. PubMed ID: 8506363

Selective requirement of myosin light chain 2v in embryonic heart function. PubMed ID: 9422794

Abnormal cardiac structure and function in mice expressing nonphosphorylatable cardiac regulatory myosin light chain 2. PubMed ID: 10409661

Acceleration of stretch activation in murine myocardium due to phosphorylation of myosin regulatory light chain. PubMed ID: 16908724

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Cardiac myosin is a substrate for zipper-interacting protein kinase (ZIPK). PubMed ID: 20038585

A novel, in-solution separation of endogenous cardiac sarcomeric proteins and identification of distinct charged variants of regulatory light chain. PubMed ID: 20445002

NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein. PubMed ID: 20668449

Myosin light chain phosphorylation is critical for adaptation to cardiac stress. PubMed ID: 23095280

Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease. PubMed ID: 22426213