Genular: Defining Cellular Identity and Function

Details for: Myo1c

Gene ID: 17913

Symbol: Myo1c

Ensembl ID: ENSMUSG00000017774

Description: myosin IC

Associated with

B-wich complex positively regulates rrna expression
(R-MMU-5250924)
Epigenetic regulation of gene expression
(R-MMU-212165)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-MMU-2029480)
Gene expression (transcription)
(R-MMU-74160)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Positive epigenetic regulation of rrna expression
(R-MMU-5250913)
Regulation of actin dynamics for phagocytic cup formation
(R-MMU-2029482)
Actin binding
(GO:0003779)
Actin cytoskeleton
(GO:0015629)
Actin filament-based movement
(GO:0030048)
Actin filament binding
(GO:0051015)
Actin filament organization
(GO:0007015)
Atp binding
(GO:0005524)
B-wich complex
(GO:0110016)
Basal plasma membrane
(GO:0009925)
Brush border
(GO:0005903)
Calmodulin binding
(GO:0005516)
Cell projection
(GO:0042995)
Cellular response to type ii interferon
(GO:0071346)
Chromatin remodeling
(GO:0006338)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytoplasmic vesicle membrane
(GO:0030659)
Cytoskeletal motor activity
(GO:0003774)
Cytosol
(GO:0005829)
Endocytosis
(GO:0006897)
Filamentous actin
(GO:0031941)
Lateral plasma membrane
(GO:0016328)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Microfilament motor activity
(GO:0000146)
Microvillus
(GO:0005902)
Myosin complex
(GO:0016459)
Nuclear body
(GO:0016604)
Nucleolus
(GO:0005730)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Phagocytic vesicle
(GO:0045335)
Phospholipid binding
(GO:0005543)
Plasma membrane
(GO:0005886)
Positive regulation of actin filament polymerization
(GO:0030838)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell migration by vascular endothelial growth factor signaling pathway
(GO:0038089)
Positive regulation of cellular response to insulin stimulus
(GO:1900078)
Positive regulation of protein targeting to membrane
(GO:0090314)
Positive regulation of transcription by rna polymerase i
(GO:0045943)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription by rna polymerase iii
(GO:0045945)
Positive regulation of vascular endothelial growth factor signaling pathway
(GO:1900748)
Protein binding
(GO:0005515)
Protein targeting to membrane
(GO:0006612)
Regulation of bicellular tight junction assembly
(GO:2000810)
Ruffle membrane
(GO:0032587)
Signaling receptor binding
(GO:0005102)
Small gtpase binding
(GO:0031267)
Stereocilium
(GO:0032420)
Stereocilium bundle
(GO:0032421)
Vesicle transport along actin filament
(GO:0030050)

Other Information

Proteins

Unconventional myosin-Ic

Genular Protein ID: 4236745678

Symbol: MYO1C_MOUSE

Name: Unconventional myosin-Ic

UniProtKB Accession Codes:

Q9WTI7 O08571 O08834 Q3TBQ4 Q3U231 Q5ND46 Q5ND48 Q5ND49 Q9ERB6 Q9QW54

Database IDs:

Citations:

PubMed ID: 9182797

Title: The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression.

PubMed ID: 9182797

DOI: 10.1016/s0896-6273(00)80312-8

PubMed ID: 11030652

Title: A myosin I isoform in the nucleus.

PubMed ID: 11030652

DOI: 10.1126/science.290.5490.337

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9119401

Title: Cloning of the genes encoding two murine and human cochlear unconventional type I myosins.

PubMed ID: 9119401

DOI: 10.1006/geno.1996.4526

PubMed ID: 8449986

Title: Mammalian myosin I alpha, I beta, and I gamma: new widely expressed genes of the myosin I family.

PubMed ID: 8449986

DOI: 10.1083/jcb.120.6.1405

PubMed ID: 11853671

Title: A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells.

PubMed ID: 11853671

DOI: 10.1016/s0092-8674(02)00629-3

PubMed ID: 12490950

Title: Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c.

PubMed ID: 12490950

DOI: 10.1038/nature01246

PubMed ID: 15014434

Title: Myo1c is designed for the adaptation response in the inner ear.

PubMed ID: 15014434

DOI: 10.1038/sj.emboj.7600169

PubMed ID: 14980509

Title: An actin-myosin complex on actively transcribing genes.

PubMed ID: 14980509

DOI: 10.1016/j.yexcr.2003.10.028

PubMed ID: 15976448

Title: PHR1, an integral membrane protein of the inner ear sensory cells, directly interacts with myosin 1c and myosin VIIa.

PubMed ID: 15976448

DOI: 10.1242/jcs.02424

PubMed ID: 16102537

Title: Fast adaptation in vestibular hair cells requires myosin-1c activity.

PubMed ID: 16102537

DOI: 10.1016/j.neuron.2005.07.024

PubMed ID: 16514417

Title: The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription.

PubMed ID: 16514417

DOI: 10.1038/sj.embor.7400657

PubMed ID: 16960872

Title: Nuclear myosin I is necessary for the formation of the first phosphodiester bond during transcription initiation by RNA polymerase II.

PubMed ID: 16960872

DOI: 10.1002/jcb.21035

PubMed ID: 16971510

Title: Myo1c binds phosphoinositides through a putative pleckstrin homology domain.

PubMed ID: 16971510

DOI: 10.1091/mbc.e06-05-0449

PubMed ID: 16492791

Title: Myo1c binds tightly and specifically to phosphatidylinositol 4,5-bisphosphate and inositol 1,4,5-trisphosphate.

PubMed ID: 16492791

DOI: 10.1073/pnas.0505685103

PubMed ID: 16957816

Title: Nuclear myosin is ubiquitously expressed and evolutionary conserved in vertebrates.

PubMed ID: 16957816

DOI: 10.1007/s00418-006-0231-0

PubMed ID: 17994197

Title: CIB1 and CaBP1 bind to the myo1c regulatory domain.

PubMed ID: 17994197

DOI: 10.1007/s10974-007-9124-7

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22918957

Title: Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesicles.

PubMed ID: 22918957

DOI: 10.1091/mbc.e12-04-0263

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 26961175

Title: A transducible nuclear/nucleolar protein, mLLP, regulates neuronal morphogenesis and synaptic transmission.

PubMed ID: 26961175

DOI: 10.1038/srep22892

Sequence Information:

Length: 1063
Mass: 121944
Checksum: 494A31B8634A1AF9
Sequence:

MALQVELIPT GEIIRVVHPH RPCKLALGSD GVRVTMESAL TARDRVGVQD FVLLENFTSE 
AAFIENLRRR FRENLIYTYI GPVLVSVNPY RDLQIYSRQH MERYRGVSFY EVPPHLFAVA 
DTVYRALRTE RRDQAVMISG ESGAGKTEAT KRLLQFYAET CPAPERGGAV RDRLLQSNPV 
LEAFGNAKTL RNDNSSRFGK YMDVQFDFKG APVGGHILSY LLEKSRVVHQ NHGERNFHVF 
YQLLEGGEEE TLRRLGLERN PQSYLYLVKG QCAKVSSIND KSDWKVMRKA LSVIDFTEDE 
VEDLLSIVAS VLHLGNIHFA ADEDSNAQVT TENQLKYLTR LLGVEGTTLR EALTHRKIIA 
KGEELLSPLN LEQAAYARDA LAKAVYSRTF TWLVRKINRS LASKDAESPS WRSTTVLGLL 
DIYGFEVFQH NSFEQFCINY CNEKLQQLFI ELTLKSEQEE YEAEGIAWEP VQYFNNKIIC 
DLVEEKFKGI ISILDEECLR PGEATDLTFL EKLEDTVKPH PHFLTHKLAD QKTRKSLDRG 
EFRLLHYAGE VTYSVTGFLD KNNDLLFRNL KETMCSSMNP IMAQCFDKSE LSDKKRPETV 
ATQFKMSLLQ LVEILRSKEP AYIRCIKPND AKQPGRFDEV LIRHQVKYLG LMENLRVRRA 
GFAYRRKYEA FLQRYKSLCP ETWPMWAGRP QDGVAVLVRH LGYKPEEYKM GRTKIFIRFP 
KTLFATEDSL EVRRQSLATK IQAAWRGFHW RQKFLRVKRS AICIQSWWRG TLGRRKAAKR 
KWAAQTIRRL IRGFILRHSP RCPENAFFLD HVRASFLLNL RRQLPRNVLD TSWPTPPPAL 
REASELLREL CMKNMVWKYC RSISPEWKQQ LQQKAVASEI FKGKKDNYPQ SVPRLFISTR 
LGTEEISPRV LQSLGSEPIQ YAVPVVKYDR KGYKPRPRQL LLTPSAVVIV EDAKVKQRID 
YANLTGISVS SLSDSLFVLH VQREDNKQKG DVVLQSDHVI ETLTKTALSA DRVNNININQ 
GSITFAGGPG RDGIIDFTSG SELLITKAKN GHLAVVAPRL NSR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Myo1c

Associated with

Other Information

The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. PubMed ID: 9182797

A myosin I isoform in the nucleus. PubMed ID: 11030652

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning of the genes encoding two murine and human cochlear unconventional type I myosins. PubMed ID: 9119401

Mammalian myosin I alpha, I beta, and I gamma: new widely expressed genes of the myosin I family. PubMed ID: 8449986

A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells. PubMed ID: 11853671

Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c. PubMed ID: 12490950

Myo1c is designed for the adaptation response in the inner ear. PubMed ID: 15014434

An actin-myosin complex on actively transcribing genes. PubMed ID: 14980509

PHR1, an integral membrane protein of the inner ear sensory cells, directly interacts with myosin 1c and myosin VIIa. PubMed ID: 15976448

Fast adaptation in vestibular hair cells requires myosin-1c activity. PubMed ID: 16102537

The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription. PubMed ID: 16514417

Nuclear myosin I is necessary for the formation of the first phosphodiester bond during transcription initiation by RNA polymerase II. PubMed ID: 16960872

Myo1c binds phosphoinositides through a putative pleckstrin homology domain. PubMed ID: 16971510

Myo1c binds tightly and specifically to phosphatidylinositol 4,5-bisphosphate and inositol 1,4,5-trisphosphate. PubMed ID: 16492791

Nuclear myosin is ubiquitously expressed and evolutionary conserved in vertebrates. PubMed ID: 16957816

CIB1 and CaBP1 bind to the myo1c regulatory domain. PubMed ID: 17994197

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesicles. PubMed ID: 22918957

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

A transducible nuclear/nucleolar protein, mLLP, regulates neuronal morphogenesis and synaptic transmission. PubMed ID: 26961175