Genular: Defining Cellular Identity and Function

Details for: Myoc

Gene ID: 17926

Symbol: Myoc

Ensembl ID: ENSMUSG00000026697

Description: myocilin

Associated with

Bone development
(GO:0060348)
Cell projection
(GO:0042995)
Cilium
(GO:0005929)
Clustering of voltage-gated sodium channels
(GO:0045162)
Collagen-containing extracellular matrix
(GO:0062023)
Cytoplasmic vesicle
(GO:0031410)
Endoplasmic reticulum
(GO:0005783)
Erbb2-erbb3 signaling pathway
(GO:0038133)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibronectin binding
(GO:0001968)
Frizzled binding
(GO:0005109)
Golgi apparatus
(GO:0005794)
Membrane
(GO:0016020)
Mesaxon
(GO:0097453)
Metal ion binding
(GO:0046872)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial intermembrane space
(GO:0005758)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion
(GO:0005739)
Myelination in peripheral nervous system
(GO:0022011)
Myelin sheath abaxonal region
(GO:0035748)
Myosin light chain binding
(GO:0032027)
Negative regulation of cell-matrix adhesion
(GO:0001953)
Negative regulation of rho protein signal transduction
(GO:0035024)
Negative regulation of stress fiber assembly
(GO:0051497)
Neuron projection development
(GO:0031175)
Node of ranvier
(GO:0033268)
Non-canonical wnt signaling pathway
(GO:0035567)
Osteoblast differentiation
(GO:0001649)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of focal adhesion assembly
(GO:0051894)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of mitochondrial depolarization
(GO:0051901)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of stress fiber assembly
(GO:0051496)
Positive regulation of substrate adhesion-dependent cell spreading
(GO:1900026)
Protein binding
(GO:0005515)
Receptor tyrosine kinase binding
(GO:0030971)
Regulation of mapk cascade
(GO:0043408)
Schmidt-lanterman incisure
(GO:0043220)
Signal transduction
(GO:0007165)
Skeletal muscle hypertrophy
(GO:0014734)

Other Information

Proteins

Myocilin

Genular Protein ID: 2765106218

Symbol: MYOC_MOUSE

Name: Myocilin

UniProtKB Accession Codes:

O70624 O70289

Database IDs:

Citations:

PubMed ID: 9588210

Title: Characterization of the mouse Myoc/Tigr gene.

PubMed ID: 9588210

DOI: 10.1006/bbrc.1998.8541

PubMed ID: 9675094

Title: Mouse myocilin (Myoc) gene expression in ocular tissues.

PubMed ID: 9675094

DOI: 10.1006/bbrc.1998.8917

PubMed ID: 9548973

Title: Characterization and comparison of the human and mouse GLC1A glaucoma genes.

PubMed ID: 9548973

DOI: 10.1101/gr.8.4.377

PubMed ID: 9680392

Title: Characterization of the murine TIGR/myocilin gene.

PubMed ID: 9680392

DOI: 10.1007/s003359900844

PubMed ID: 12019210

Title: Optimedin: a novel olfactomedin-related protein that interacts with myocilin.

PubMed ID: 12019210

DOI: 10.1093/hmg/11.11.1291

PubMed ID: 16392033

Title: Interaction of myocilin with gamma-synuclein affects its secretion and aggregation.

PubMed ID: 16392033

DOI: 10.1007/s10571-005-8471-4

PubMed ID: 19188438

Title: Myocilin is a modulator of Wnt signaling.

PubMed ID: 19188438

DOI: 10.1128/mcb.01274-08

PubMed ID: 22371502

Title: Myocilin interacts with syntrophins and is member of dystrophin-associated protein complex.

PubMed ID: 22371502

DOI: 10.1074/jbc.m111.224063

PubMed ID: 23629661

Title: Myocilin stimulates osteogenic differentiation of mesenchymal stem cells through mitogen-activated protein kinase signaling.

PubMed ID: 23629661

DOI: 10.1074/jbc.m112.422972

PubMed ID: 23897819

Title: Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling.

PubMed ID: 23897819

DOI: 10.1074/jbc.m112.446138

Sequence Information:

Length: 490
Mass: 55314
Checksum: 2F090571E97B0425
Sequence:

MPALHLLFLA CLVWGMGART AQFRKANDRS GRCQYTFTVA SPNESSCPRE DQAMSAIQDL 
QRDSSIQHAD LESTKARVRS LESLLHQMTL GRVTGTQEAQ EGLQGQLGAL RRERDQLETQ 
TRDLEAAYNN LLRDKSALEE EKRQLEQENE DLARRLESSS EEVTRLRRGQ CPSTQYPSQD 
MLPGSREVSQ WNLDTLAFQE LKSELTEVPA SQILKENPSG RPRSKEGDKG CGALVWVGEP 
VTLRTAETIA GKYGVWMRDP KPTHPYTQES TWRIDTVGTE IRQVFEYSQI SQFEQGYPSK 
VHVLPRALES TGAVVYAGSL YFQGAESRTV VRYELDTETV KAEKEIPGAG YHGHFPYAWG 
GYTDIDLAVD ESGLWVIYST EEAKGAIVLS KLNPANLELE RTWETNIRKQ SVANAFVICG 
ILYTVSSYSS AHATVNFAYD TKTGTSKTLT IPFTNRYKYS SMIDYNPLER KLFAWDNFNM 
VTYDIKLLEM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Myoc

Associated with

Other Information

Characterization of the mouse Myoc/Tigr gene. PubMed ID: 9588210

Mouse myocilin (Myoc) gene expression in ocular tissues. PubMed ID: 9675094

Characterization and comparison of the human and mouse GLC1A glaucoma genes. PubMed ID: 9548973

Characterization of the murine TIGR/myocilin gene. PubMed ID: 9680392

Optimedin: a novel olfactomedin-related protein that interacts with myocilin. PubMed ID: 12019210

Interaction of myocilin with gamma-synuclein affects its secretion and aggregation. PubMed ID: 16392033

Myocilin is a modulator of Wnt signaling. PubMed ID: 19188438

Myocilin interacts with syntrophins and is member of dystrophin-associated protein complex. PubMed ID: 22371502

Myocilin stimulates osteogenic differentiation of mesenchymal stem cells through mitogen-activated protein kinase signaling. PubMed ID: 23629661

Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling. PubMed ID: 23897819