Genular: Defining Cellular Identity and Function

Details for: Myod1

Gene ID: 17927

Symbol: Myod1

Ensembl ID: ENSMUSG00000009471

Description: myogenic differentiation 1

Associated with

Developmental biology
(R-MMU-1266738)
Myogenesis
(R-MMU-525793)
Bhlh transcription factor binding
(GO:0043425)
Cardiac muscle cell differentiation
(GO:0055007)
Cell differentiation
(GO:0030154)
Cellular response to estradiol stimulus
(GO:0071392)
Cellular response to glucocorticoid stimulus
(GO:0071385)
Cellular response to oxygen levels
(GO:0071453)
Cellular response to starvation
(GO:0009267)
Cellular response to tumor necrosis factor
(GO:0071356)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromatin dna binding
(GO:0031490)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity
(GO:0001216)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
E-box binding
(GO:0070888)
Enzyme binding
(GO:0019899)
Euchromatin
(GO:0000791)
Multicellular organism development
(GO:0007275)
Muscle cell differentiation
(GO:0042692)
Muscle organ development
(GO:0007517)
Myoblast differentiation
(GO:0045445)
Myoblast fate determination
(GO:0007518)
Myoblast fusion
(GO:0007520)
Myofibril
(GO:0030016)
Myotube cell development
(GO:0014904)
Myotube differentiation
(GO:0014902)
Myotube differentiation involved in skeletal muscle regeneration
(GO:0014908)
Negative regulation of chromatin binding
(GO:0035562)
Negative regulation of myoblast proliferation
(GO:2000818)
Nuclear receptor binding
(GO:0016922)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of binding
(GO:0051099)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of muscle cell differentiation
(GO:0051149)
Positive regulation of myoblast differentiation
(GO:0045663)
Positive regulation of myoblast fusion
(GO:1901741)
Positive regulation of skeletal muscle fiber development
(GO:0048743)
Positive regulation of skeletal muscle tissue regeneration
(GO:0043415)
Positive regulation of snrna transcription by rna polymerase ii
(GO:1905382)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Promoter-specific chromatin binding
(GO:1990841)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Protein homodimerization activity
(GO:0042803)
Regulation of alternative mrna splicing, via spliceosome
(GO:0000381)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Regulation of rna splicing
(GO:0043484)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Skeletal muscle cell differentiation
(GO:0035914)
Skeletal muscle fiber adaptation
(GO:0043503)
Skeletal muscle fiber development
(GO:0048741)
Skeletal muscle tissue development
(GO:0007519)
Skeletal muscle tissue regeneration
(GO:0043403)
Striated muscle cell differentiation
(GO:0051146)
Transcription by rna polymerase ii
(GO:0006366)
Transcription factor binding
(GO:0008134)
Transcription regulator complex
(GO:0005667)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Myoblast determination protein 1

Genular Protein ID: 1904506257

Symbol: MYOD1_MOUSE

Name: Myoblast determination protein 1

UniProtKB Accession Codes:

P10085 Q8C6B1

Database IDs:

Citations:

PubMed ID: 3690668

Title: Expression of a single transfected cDNA converts fibroblasts to myoblasts.

PubMed ID: 3690668

DOI: 10.1016/0092-8674(87)90585-x

PubMed ID: 1754380

Title: Characterisation of a genomic clone covering the structural mouse MyoD1 gene and its promoter region.

PubMed ID: 1754380

DOI: 10.1093/nar/19.23.6433

PubMed ID: 3286015

Title: Myogenic lineage determination and differentiation: evidence for a regulatory gene pathway.

PubMed ID: 3286015

DOI: 10.1016/0092-8674(88)90095-5

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3175662

Title: MyoD1: a nuclear phosphoprotein requiring a Myc homology region to convert fibroblasts to myoblasts.

PubMed ID: 3175662

DOI: 10.1126/science.3175662

PubMed ID: 9029156

Title: p300 is required for MyoD-dependent cell cycle arrest and muscle-specific gene transcription.

PubMed ID: 9029156

DOI: 10.1093/emboj/16.2.369

PubMed ID: 9343420

Title: The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, Twist.

PubMed ID: 9343420

DOI: 10.1128/mcb.17.11.6563

PubMed ID: 11532390

Title: Control of muscle development by dueling HATs and HDACs.

PubMed ID: 11532390

DOI: 10.1016/s0959-437x(00)00224-0

PubMed ID: 12037670

Title: Activation of MyoD-dependent transcription by cdk9/cyclin T2.

PubMed ID: 12037670

DOI: 10.1038/sj.onc.1205493

PubMed ID: 12887892

Title: Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state.

PubMed ID: 12887892

DOI: 10.1016/s1097-2765(03)00226-0

PubMed ID: 17011493

Title: The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation.

PubMed ID: 17011493

DOI: 10.1016/j.devcel.2006.08.003

PubMed ID: 16901893

Title: Control of MyoD function during initiation of muscle differentiation by an autocrine signaling pathway activated by insulin-like growth factor-II.

PubMed ID: 16901893

DOI: 10.1074/jbc.m605445200

PubMed ID: 19723804

Title: The small chromatin-binding protein p8 coordinates the association of anti-proliferative and pro-myogenic proteins at the myogenin promoter.

PubMed ID: 19723804

DOI: 10.1242/jcs.048678

PubMed ID: 20124407

Title: Glucocorticoid-induced leucine zipper (GILZ) and long GILZ inhibit myogenic differentiation and mediate anti-myogenic effects of glucocorticoids.

PubMed ID: 20124407

DOI: 10.1074/jbc.m109.070136

PubMed ID: 21832073

Title: Histone methyltransferase SETD3 regulates muscle differentiation.

PubMed ID: 21832073

DOI: 10.1074/jbc.m110.203307

PubMed ID: 21798092

Title: Sequential association of myogenic regulatory factors and E proteins at muscle-specific genes.

PubMed ID: 21798092

DOI: 10.1186/2044-5040-1-14

PubMed ID: 22569126

Title: Chd2 interacts with H3.3 to determine myogenic cell fate.

PubMed ID: 22569126

DOI: 10.1038/emboj.2012.136

PubMed ID: 8181063

Title: Crystal structure of MyoD bHLH domain-DNA complex: perspectives on DNA recognition and implications for transcriptional activation.

PubMed ID: 8181063

DOI: 10.1016/0092-8674(94)90159-7

Sequence Information:

Length: 318
Mass: 34233
Checksum: AEC6572277A78D54
Sequence:

MELLSPPLRD IDLTGPDGSL CSFETADDFY DDPCFDSPDL RFFEDLDPRL VHMGALLKPE 
EHAHFPTAVH PGPGAREDEH VRAPSGHHQA GRCLLWACKA CKRKTTNADR RKAATMRERR 
RLSKVNEAFE TLKRCTSSNP NQRLPKVEIL RNAIRYIEGL QALLRDQDAA PPGAAAFYAP 
GPLPPGRGSE HYSGDSDASS PRSNCSDGMM DYSGPPSGPR RQNGYDTAYY SEAARESRPG 
KSAAVSSLDC LSSIVERIST DSPAAPALLL ADAPPESPPG PPEGASLSDT EQGTQTPSPD 
AAPQCPAGSN PNAIYQVL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Myod1

Associated with

Other Information

Expression of a single transfected cDNA converts fibroblasts to myoblasts. PubMed ID: 3690668

Characterisation of a genomic clone covering the structural mouse MyoD1 gene and its promoter region. PubMed ID: 1754380

Myogenic lineage determination and differentiation: evidence for a regulatory gene pathway. PubMed ID: 3286015

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

MyoD1: a nuclear phosphoprotein requiring a Myc homology region to convert fibroblasts to myoblasts. PubMed ID: 3175662

p300 is required for MyoD-dependent cell cycle arrest and muscle-specific gene transcription. PubMed ID: 9029156

The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, Twist. PubMed ID: 9343420

Control of muscle development by dueling HATs and HDACs. PubMed ID: 11532390

Activation of MyoD-dependent transcription by cdk9/cyclin T2. PubMed ID: 12037670

Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. PubMed ID: 12887892

The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation. PubMed ID: 17011493

Control of MyoD function during initiation of muscle differentiation by an autocrine signaling pathway activated by insulin-like growth factor-II. PubMed ID: 16901893

The small chromatin-binding protein p8 coordinates the association of anti-proliferative and pro-myogenic proteins at the myogenin promoter. PubMed ID: 19723804

Glucocorticoid-induced leucine zipper (GILZ) and long GILZ inhibit myogenic differentiation and mediate anti-myogenic effects of glucocorticoids. PubMed ID: 20124407

Histone methyltransferase SETD3 regulates muscle differentiation. PubMed ID: 21832073

Sequential association of myogenic regulatory factors and E proteins at muscle-specific genes. PubMed ID: 21798092

Chd2 interacts with H3.3 to determine myogenic cell fate. PubMed ID: 22569126

Crystal structure of MyoD bHLH domain-DNA complex: perspectives on DNA recognition and implications for transcriptional activation. PubMed ID: 8181063