Details for: Myog

Gene ID: 17928

Symbol: Myog

Ensembl ID: ENSMUSG00000026459

Description: myogenin

Associated with

  • Developmental biology
    (R-MMU-1266738)
  • Myogenesis
    (R-MMU-525793)
  • Cell cycle
    (GO:0007049)
  • Cell differentiation
    (GO:0030154)
  • Cellular response to estradiol stimulus
    (GO:0071392)
  • Cellular response to growth factor stimulus
    (GO:0071363)
  • Cellular response to lithium ion
    (GO:0071285)
  • Cellular response to tumor necrosis factor
    (GO:0071356)
  • Chromatin dna binding
    (GO:0031490)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Dna-binding transcription activator activity
    (GO:0001216)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • E-box binding
    (GO:0070888)
  • Multicellular organism development
    (GO:0007275)
  • Muscle cell differentiation
    (GO:0042692)
  • Muscle organ development
    (GO:0007517)
  • Myotube differentiation
    (GO:0014902)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of glycolytic process
    (GO:0045820)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Ossification
    (GO:0001503)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of muscle atrophy
    (GO:0014737)
  • Positive regulation of myoblast differentiation
    (GO:0045663)
  • Positive regulation of myotube differentiation
    (GO:0010831)
  • Positive regulation of oxidative phosphorylation
    (GO:1903862)
  • Positive regulation of skeletal muscle fiber development
    (GO:0048743)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein-dna complex
    (GO:0032993)
  • Protein binding
    (GO:0005515)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of cell cycle
    (GO:0051726)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of myoblast fusion
    (GO:1901739)
  • Regulation of skeletal muscle satellite cell proliferation
    (GO:0014842)
  • Response to denervation involved in regulation of muscle adaptation
    (GO:0014894)
  • Response to electrical stimulus involved in regulation of muscle adaptation
    (GO:0014878)
  • Response to muscle activity involved in regulation of muscle adaptation
    (GO:0014873)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Skeletal muscle cell differentiation
    (GO:0035914)
  • Skeletal muscle fiber development
    (GO:0048741)
  • Skeletal muscle tissue development
    (GO:0007519)
  • Striated muscle atrophy
    (GO:0014891)

Other Information

Genular Protein ID: 2097782199

Symbol: MYOG_MOUSE

Name: Myogenin

UniProtKB Accession Codes:

P12979

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CORUM 1 CTD 1 DIP 1 DNASU 1 EMBL 5 EPD 1 Ensembl 1 GO 43 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 2473006

Title: A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program.

PubMed ID: 2473006

DOI: 10.1101/gad.3.5.628

PubMed ID: 2172083

Title:

PubMed ID: 2172083

DOI: 10.1101/gad.4.8.1450

PubMed ID: 1324403

Title: Analysis of the myogenin promoter reveals an indirect pathway for positive autoregulation mediated by the muscle-specific enhancer factor MEF-2.

PubMed ID: 1324403

DOI: 10.1128/mcb.12.9.3665-3677.1992

PubMed ID: 2168405

Title: Myogenin contains two domains conserved among myogenic factors.

PubMed ID: 2168405

DOI: 10.1016/s0021-9258(18)77244-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2552320

Title: Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis.

PubMed ID: 2552320

DOI: 10.1038/341303a0

PubMed ID: 1705035

Title: Myogenin and MyoD join a family of skeletal muscle genes regulated by electrical activity.

PubMed ID: 1705035

DOI: 10.1073/pnas.88.4.1349

PubMed ID: 8393145

Title: Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene.

PubMed ID: 8393145

DOI: 10.1038/364501a0

PubMed ID: 8393146

Title: Myogenin gene disruption results in perinatal lethality because of severe muscle defect.

PubMed ID: 8393146

DOI: 10.1038/364532a0

PubMed ID: 7929574

Title: Somite subdomains, muscle cell origins, and the four muscle regulatory factor proteins.

PubMed ID: 7929574

DOI: 10.1083/jcb.127.1.95

PubMed ID: 12196028

Title: Analysis of the DNA-binding properties of MyoD, myogenin, and E12 by fluorescence anisotropy.

PubMed ID: 12196028

DOI: 10.1021/bi025528q

PubMed ID: 15706034

Title: An initial blueprint for myogenic differentiation.

PubMed ID: 15706034

DOI: 10.1101/gad.1281105

PubMed ID: 16407395

Title: Loss of myogenin in postnatal life leads to normal skeletal muscle but reduced body size.

PubMed ID: 16407395

DOI: 10.1242/dev.02249

PubMed ID: 16424906

Title: Skeletal muscle specification by myogenin and Mef2D via the SWI/SNF ATPase Brg1.

PubMed ID: 16424906

DOI: 10.1038/sj.emboj.7600943

PubMed ID: 16437161

Title: Global and gene-specific analyses show distinct roles for Myod and Myog at a common set of promoters.

PubMed ID: 16437161

DOI: 10.1038/sj.emboj.7600958

PubMed ID: 21465538

Title: Myogenin regulates denervation-dependent muscle atrophy in mouse soleus muscle.

PubMed ID: 21465538

DOI: 10.1002/jcb.23136

PubMed ID: 21798092

Title: Sequential association of myogenic regulatory factors and E proteins at muscle-specific genes.

PubMed ID: 21798092

DOI: 10.1186/2044-5040-1-14

PubMed ID: 22847234

Title: Comparative expression profiling identifies differential roles for Myogenin and p38alpha MAPK signaling in myogenesis.

PubMed ID: 22847234

DOI: 10.1093/jmcb/mjs045

PubMed ID: 22235349

Title: Down-regulation of myogenin can reverse terminal muscle cell differentiation.

PubMed ID: 22235349

DOI: 10.1371/journal.pone.0029896

PubMed ID: 23364797

Title: Myogenin recruits the histone chaperone facilitates chromatin transcription (FACT) to promote nucleosome disassembly at muscle-specific genes.

PubMed ID: 23364797

DOI: 10.1074/jbc.m112.426718

Sequence Information:

  • Length: 224
  • Mass: 25203
  • Checksum: CC7352C1EDF9D3D8
  • Sequence:
    • MELYETSPYF YQEPHFYDGE NYLPVHLQGF EPPGYERTEL SLSPEARGPL EEKGLGTPEH 
CPGQCLPWAC KVCKRKSVSV DRRRAATLRE KRRLKKVNEA FEALKRSTLL NPNQRLPKVE 
ILRSAIQYIE RLQALLSSLN QEERDLRYRG GGGPQPMVPS ECNSHSASCS PEWGNALEFG 
PNPGDHLLAA DPTDAHNLHS LTSIVDSITV EDMSVAFPDE TMPN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.