Genular: Defining Cellular Identity and Function

Details for: Ppp1r12a

Gene ID: 17931

Symbol: Ppp1r12a

Ensembl ID: ENSMUSG00000019907

Description: protein phosphatase 1, regulatory subunit 12A

Associated with

Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
G2/m transition
(R-MMU-69275)
Mitotic g2-g2/m phases
(R-MMU-453274)
Regulation of plk1 activity at g2/m transition
(R-MMU-2565942)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate paks
(R-MMU-5627123)
Rho gtpases activate pkns
(R-MMU-5625740)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
14-3-3 protein binding
(GO:0071889)
A band
(GO:0031672)
Actin cytoskeleton
(GO:0015629)
Cellular response to xenobiotic stimulus
(GO:0071466)
Centrosome
(GO:0005813)
Centrosome cycle
(GO:0007098)
Contractile fiber
(GO:0043292)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Enzyme inhibitor activity
(GO:0004857)
Kinetochore
(GO:0000776)
Mitotic cell cycle
(GO:0000278)
Negative regulation of catalytic activity
(GO:0043086)
Nucleolus
(GO:0005730)
Phosphatase regulator activity
(GO:0019208)
Phosphoprotein phosphatase activity
(GO:0004721)
Plasma membrane
(GO:0005886)
Positive regulation of myosin-light-chain-phosphatase activity
(GO:0035508)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein dephosphorylation
(GO:0006470)
Protein kinase binding
(GO:0019901)
Ptw/pp1 phosphatase complex
(GO:0072357)
Regulation of cell adhesion
(GO:0030155)
Regulation of myosin-light-chain-phosphatase activity
(GO:0035507)
Regulation of nucleocytoplasmic transport
(GO:0046822)
Signal transduction
(GO:0007165)
Z disc
(GO:0030018)

Other Information

Proteins

Protein phosphatase 1 regulatory subunit 12A

Genular Protein ID: 1883516882

Symbol: MYPT1_MOUSE

Name: Protein phosphatase 1 regulatory subunit 12A

UniProtKB Accession Codes:

Q9DBR7 Q05A74 Q8CBV2 Q99NB6

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11342221

Title: Molecular cloning and analysis of the 5'-flanking region of human MYPT1 gene.

PubMed ID: 11342221

DOI: 10.1016/s0167-4781(00)00285-2

PubMed ID: 8662509

Title: Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase).

PubMed ID: 8662509

DOI: 10.1126/science.273.5272.245

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20634291

Title: Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy.

PubMed ID: 20634291

DOI: 10.1074/jbc.m110.143966

PubMed ID: 31883643

Title: Loss-of-function variants in PPP1R12A: from isolated sex reversal to holoprosencephaly spectrum and urogenital malformations.

PubMed ID: 31883643

DOI: 10.1016/j.ajhg.2019.12.004

Sequence Information:

Length: 1029
Mass: 114996
Checksum: C466573AC1DFC81F
Sequence:

MKMADAKQKR NEQLKRWIGS ETDLEPPVVK RQKTKVKFDD GAVFLAACSS GDTDEVLKLL 
HRGADINYAN VDGLTALHQA CIDDNVDMVK FLVENGANIN QPDNEGWIPL HAAASCGYLD 
IAEFLIGQGA HVGAVNSEGD TPLDIAEEEA MEELLQNEVN RQGVDIEAAR KEEERVMLRD 
ARQWLNSGHI SDVRHAKSGG TALHVAAAKG YTEVLKLLIQ AGYDVNIKDY DGWTPLHAAA 
HWGKEEACRI LVDNLCDMET VNKVGQTAFD VADEDILGYL EELQKKQTLL HSEKRDKKSP 
LIESTANMEN NQPQKAFKNK ETLIIEPEKN ASRIESLEHE KADEEEEGKK DESSCSSEED 
EEDDSESEAE TDKTKPMASV SNAHTSSTQA APAAVTAPTL SSNQGTPTSP VKKFPISTTK 
ISPKEEERKD ESPASWRLGL RKTGSYGALA EISASKEAQK EKDTAGVMRS ASSPRLSSSL 
DNKEKEKDNK GTRLAYVTPT IPRRLASTSD IEEKENRESS SLRTSSSYTR RKWEDDLKKN 
SSINEGSTYH RSCSFGRRQD DLISCSVPST TSTPTVTSAA GLQRSLPSST STAAKTPPGS 
SSAGTQSSTS NRLWAEDSTE KEKDSAPTAV TIPVAPTVVN AAAPSTTTLT TTTAGTVSEV 
RERRRSYLTP VRDEESESQR KARSRQARQS RRSTQGVTLT DLQEAEKTIG RSRSTRTREQ 
ENEEKEKEEK EKQDKEKQEE KKESEASRED EYKQKYSRTY DETYTRYRPV STSSSSAPSS 
SSLSTLGSTL YASSQLNRPN SLVGITSAYS RGLAKENERE GEKKEEEKEG EDKSQPKSIR 
ERRRPREKRR STGVSFWTQD SDENEQERQS DTEDGSSKRE TQTDSVSRYD SSSTSSSDRY 
DSLLGRSASY SYLEDRKPYS SRLEKDDSTD FKKLYEQILA ENEKLKAQLH DTNMELTDLK 
LQLEKATQRQ ERFADRSQLE MEKRERRALE RRISEMEEEL KMLPDLKADN QRLKDENGAL 
IRVISKLSK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ppp1r12a

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular cloning and analysis of the 5'-flanking region of human MYPT1 gene. PubMed ID: 11342221

Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). PubMed ID: 8662509

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy. PubMed ID: 20634291

Loss-of-function variants in PPP1R12A: from isolated sex reversal to holoprosencephaly spectrum and urogenital malformations. PubMed ID: 31883643