Genular: Defining Cellular Identity and Function

Details for: Nck1

Gene ID: 17973

Symbol: Nck1

Ensembl ID: ENSMUSG00000032475

Description: non-catalytic region of tyrosine kinase adaptor protein 1

Associated with

Adaptive immune system
(R-MMU-1280218)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-MMU-983695)
Antiviral mechanism by ifn-stimulated genes
(R-MMU-1169410)
Axon guidance
(R-MMU-422475)
Cell-cell communication
(R-MMU-1500931)
Cytokine signaling in immune system
(R-MMU-1280215)
Dcc mediated attractive signaling
(R-MMU-418885)
Developmental biology
(R-MMU-1266738)
Downstream signal transduction
(R-MMU-186763)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-MMU-2029480)
Generation of second messenger molecules
(R-MMU-202433)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interferon signaling
(R-MMU-913531)
Nephrin family interactions
(R-MMU-373753)
Nervous system development
(R-MMU-9675108)
Netrin-1 signaling
(R-MMU-373752)
Pkr-mediated signaling
(R-MMU-9833482)
Regulation of actin dynamics for phagocytic cup formation
(R-MMU-2029482)
Rho gtpase cycle
(R-MMU-9012999)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate wasps and waves
(R-MMU-5663213)
Rhou gtpase cycle
(R-MMU-9013420)
Rhov gtpase cycle
(R-MMU-9013424)
Signaling by pdgf
(R-MMU-186797)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by the b cell receptor (bcr)
(R-MMU-983705)
Signaling by vegf
(R-MMU-194138)
Tcr signaling
(R-MMU-202403)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Actin filament organization
(GO:0007015)
Antiviral innate immune response
(GO:0140374)
Cell-cell junction
(GO:0005911)
Cell migration
(GO:0016477)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endoplasmic reticulum
(GO:0005783)
Ephrin receptor binding
(GO:0046875)
Ephrin receptor signaling pathway
(GO:0048013)
Eukaryotic initiation factor eif2 binding
(GO:0071074)
Lamellipodium assembly
(GO:0030032)
Molecular condensate scaffold activity
(GO:0140693)
Negative regulation of endoplasmic reticulum stress-induced eif2 alpha phosphorylation
(GO:1903912)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Negative regulation of peptidyl-serine phosphorylation
(GO:0033137)
Negative regulation of perk-mediated unfolded protein response
(GO:1903898)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of actin filament polymerization
(GO:0030838)
Positive regulation of cap-dependent translational initiation
(GO:1903676)
Positive regulation of cap-independent translational initiation
(GO:1903679)
Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
(GO:1902237)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of peptidyl-serine dephosphorylation
(GO:1902310)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of translation in response to endoplasmic reticulum stress
(GO:0036493)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase inhibitor activity
(GO:0004860)
Protein phosphatase type 1 complex
(GO:0000164)
Receptor tyrosine kinase binding
(GO:0030971)
Regulation of cell migration
(GO:0030334)
Regulation of translation
(GO:0006417)
Response to endoplasmic reticulum stress
(GO:0034976)
Response to other organism
(GO:0051707)
Ribosome
(GO:0005840)
Signaling adaptor activity
(GO:0035591)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Substrate-dependent cell migration, cell extension
(GO:0006930)
T cell activation
(GO:0042110)
Vesicle membrane
(GO:0012506)

Other Information

Proteins

Cytoplasmic protein Nck1
Q8BH99_MOUSE

Genular Protein ID: 990968204

Symbol: NCK1_MOUSE

Name: Cytoplasmic protein Nck1

UniProtKB Accession Codes:

Q99M51 O55032 Q9Z279

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9722576

Title: Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules.

PubMed ID: 9722576

DOI: 10.1074/jbc.273.36.23410

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 377
Mass: 42891
Checksum: 671BBFC870A88EB9
Sequence:

MAEEVVVVAK FDYVAQQEQE LDIKKNERLW LLDDSKSWWR VRNSMNKTGF VPSNYVERKN 
SARKASIVKN LKDTLGIGKV KRKPSVPDTA SPADDSFVDP GERLYDLNMP AFVKFNYMAE 
REDELSLIKG TKVIVMEKCS DGWWRGSYNG QIGWFPSNYV TEEGDSPLGD HVGSLSEKLA 
AVVNNLNTGQ VLHVVQALYP FSSSNDEELN FEKGDVMDVI EKPENDPEWW KCRKINGMVG 
LVPKNYVTIM QNNPLTSGLE PSPPQCDYIR PSLTGKFAGN PWYYGKVTRH QAEMALNERG 
HEGDFLIRDS ESSPNDFSVS LKAQGKNKHF KVQLKETVYC IGQRKFSTME ELVEHYKKAP 
IFTSEQGEKL YLVKHLS

Genular Protein ID: 1188454900

Symbol: Q8BH99_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8BH99

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 313
Mass: 35551
Checksum: 3DCA26671522A024
Sequence:

MDWLNIFKDF FSIGKVKRKP SVPDTASPAD DSFVDPGERL YDLNMPAFVK FNYMAEREDE 
LSLIKGTKVI VMEKCSDGWW RGSYNGQIGW FPSNYVTEEG DSPLGDHVGS LSEKLAAVVN 
NLNTGQVLHV VQALYPFSSS NDEELNFEKG DVMDVIEKPE NDPEWWKCRK INGMVGLVPK 
NYVTIMQNNP LTSGLEPSPP QCDYIRPSLT GKFAGNPWYY GKVTRHQAEM ALNERGHEGD 
FLIRDSESSP NDFSVSLKAQ GKNKHFKVQL KETVYCIGQR KFSTMEELVE HYKKAPIFTS 
EQGEKLYLVK HLS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nck1

Associated with

Other Information

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules. PubMed ID: 9722576

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Database document:

PubMed ID: 19468303

PubMed ID: 15489334

PubMed ID: 9722576

PubMed ID: 18034455

PubMed ID: 21183079

PubMed ID: 10349636

PubMed ID: 11042159

PubMed ID: 11076861

PubMed ID: 11217851

PubMed ID: 12466851

PubMed ID: 16141073

PubMed ID: 18034455

PubMed ID: 19468303

PubMed ID: 21183079