Genular: Defining Cellular Identity and Function

Details for: Ncl

Gene ID: 17975

Symbol: Ncl

Ensembl ID: ENSMUSG00000026234

Description: nucleolin

Associated with

Major pathway of rrna processing in the nucleolus and cytosol
(R-MMU-6791226)
Metabolism of rna
(R-MMU-8953854)
Rrna processing
(R-MMU-72312)
Rrna processing in the nucleus and cytosol
(R-MMU-8868773)
Angiogenesis
(GO:0001525)
Calcium ion binding
(GO:0005509)
Cell cortex
(GO:0005938)
Cell surface
(GO:0009986)
Cellular response to epidermal growth factor stimulus
(GO:0071364)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Cellular response to lipopolysaccharide
(GO:0071222)
Chromosome
(GO:0005694)
Cornified envelope
(GO:0001533)
Cytoplasm
(GO:0005737)
Cytoplasmic ribonucleoprotein granule
(GO:0036464)
Dense fibrillar component
(GO:0001651)
Dna binding
(GO:0003677)
Dna topoisomerase binding
(GO:0044547)
Endocytosis
(GO:0006897)
Erbb-4 class receptor binding
(GO:1990631)
Fibrillar center
(GO:0001650)
Histone binding
(GO:0042393)
Identical protein binding
(GO:0042802)
Insulin receptor substrate binding
(GO:0043560)
Laminin binding
(GO:0043236)
Mrna 5'-utr binding
(GO:0048027)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Negative regulation of translation
(GO:0017148)
Nucleic acid binding
(GO:0003676)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Ph domain binding
(GO:0042731)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of mrna splicing, via spliceosome
(GO:0048026)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription of nucleolar large rrna by rna polymerase i
(GO:1901838)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Protein binding
(GO:0005515)
Regulation of peptidyl-tyrosine phosphorylation
(GO:0050730)
Regulation of rrna processing
(GO:2000232)
Ribonucleoprotein complex
(GO:1990904)
Rna binding
(GO:0003723)
Rrna primary transcript binding
(GO:0042134)
Selenocysteine insertion sequence binding
(GO:0035368)
Sequence-specific dna binding
(GO:0043565)
Signaling receptor binding
(GO:0005102)
Single-stranded dna binding
(GO:0003697)
Spliceosomal complex
(GO:0005681)
Telomeric dna binding
(GO:0042162)

Other Information

Proteins

Nucleolin

Genular Protein ID: 1849955735

Symbol: NUCL_MOUSE

Name: Nucleolin

UniProtKB Accession Codes:

P09405 Q548M9 Q61991 Q8BQD8 Q99K50

Database IDs:

Citations:

PubMed ID: 3137346

Title: Structure of the mouse nucleolin gene. The complete sequence reveals that each RNA binding domain is encoded by two independent exons.

PubMed ID: 3137346

DOI: 10.1016/0022-2836(88)90476-7

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2906027

Title: Sequence and structure of the nucleolin promoter in rodents: characterization of a strikingly conserved CpG island.

PubMed ID: 2906027

DOI: 10.1016/0378-1119(88)90600-2

PubMed ID: 1860869

Title: Granzyme A binding to target cell proteins. Granzyme A binds to and cleaves nucleolin in vitro.

PubMed ID: 1860869

DOI: 10.1016/s0021-9258(18)98743-0

PubMed ID: 8065340

Title: Purification and characterization of nucleolin and its identification as a transcription repressor.

PubMed ID: 8065340

DOI: 10.1128/mcb.14.9.6068-6074.1994

PubMed ID: 9642267

Title: A B-cell-specific DNA recombination complex.

PubMed ID: 9642267

DOI: 10.1074/jbc.273.27.17025

PubMed ID: 17622165

Title: A differential phosphoproteomic analysis of retinoic acid-treated P19 cells.

PubMed ID: 17622165

DOI: 10.1021/pr070122r

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19524510

Title: Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation.

PubMed ID: 19524510

DOI: 10.1016/j.cell.2009.05.020

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21474449

Title: Structure and function of the N-terminal nucleolin binding domain of nuclear valosin-containing protein-like 2 (NVL2) harboring a nucleolar localization signal.

PubMed ID: 21474449

DOI: 10.1074/jbc.m110.174680

PubMed ID: 21518874

Title: Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation.

PubMed ID: 21518874

DOI: 10.1073/pnas.1104423108

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 24991885

Title: Lrrc34, a novel nucleolar protein, interacts with npm1 and ncl and has an impact on pluripotent stem cells.

PubMed ID: 24991885

DOI: 10.1089/scd.2013.0470

PubMed ID: 28784777

Title: Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis.

PubMed ID: 28784777

DOI: 10.1073/pnas.1703494114

Sequence Information:

Length: 707
Mass: 76723
Checksum: EE2CE2ACDBF54CD4
Sequence:

MVKLAKAGKT HGEAKKMAPP PKEVEEDSED EEMSEDEDDS SGEEEVVIPQ KKGKKATTTP 
AKKVVVSQTK KAAVPTPAKK AAVTPGKKAV ATPAKKNITP AKVIPTPGKK GAAQAKALVP 
TPGKKGAATP AKGAKNGKNA KKEDSDEDED EEDEDDSDED EDDEEEDEFE PPIVKGVKPA 
KAAPAAPASE DEEDDEDEDD EEDDDEEEED DSEEEVMEIT TAKGKKTPAK VVPMKAKSVA 
EEEDDEEEDE DDEDEDDEEE DDEDDDEEEE EEEPVKAAPG KRKKEMTKQK EAPEAKKQKV 
EGSEPTTPFN LFIGNLNPNK SVNELKFAIS ELFAKNDLAV VDVRTGTNRK FGYVDFESAE 
DLEKALELTG LKVFGNEIKL EKPKGRDSKK VRAARTLLAK NLSFNITEDE LKEVFEDAME 
IRLVSQDGKS KGIAYIEFKS EADAEKNLEE KQGAEIDGRS VSLYYTGEKG QRQERTGKTS 
TWSGESKTLV LSNLSYSATK ETLEEVFEKA TFIKVPQNPH GKPKGYAFIE FASFEDAKEA 
LNSCNKMEIE GRTIRLELQG SNSRSQPSKT LFVKGLSEDT TEETLKESFE GSVRARIVTD 
RETGSSKGFG FVDFNSEEDA KAAKEAMEDG EIDGNKVTLD WAKPKGEGGF GGRGGGRGGF 
GGRGGGRGGR GGFGGRGRGG FGGRGGFRGG RGGGGDFKPQ GKKTKFE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ncl

Associated with

Other Information

Structure of the mouse nucleolin gene. The complete sequence reveals that each RNA binding domain is encoded by two independent exons. PubMed ID: 3137346

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Sequence and structure of the nucleolin promoter in rodents: characterization of a strikingly conserved CpG island. PubMed ID: 2906027

Granzyme A binding to target cell proteins. Granzyme A binds to and cleaves nucleolin in vitro. PubMed ID: 1860869

Purification and characterization of nucleolin and its identification as a transcription repressor. PubMed ID: 8065340

A B-cell-specific DNA recombination complex. PubMed ID: 9642267

A differential phosphoproteomic analysis of retinoic acid-treated P19 cells. PubMed ID: 17622165

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. PubMed ID: 19524510

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Structure and function of the N-terminal nucleolin binding domain of nuclear valosin-containing protein-like 2 (NVL2) harboring a nucleolar localization signal. PubMed ID: 21474449

Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation. PubMed ID: 21518874

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

Lrrc34, a novel nucleolar protein, interacts with npm1 and ncl and has an impact on pluripotent stem cells. PubMed ID: 24991885

Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis. PubMed ID: 28784777