Genular: Defining Cellular Identity and Function

Details for: Ncoa1

Gene ID: 17977

Symbol: Ncoa1

Ensembl ID: ENSMUSG00000020647

Description: nuclear receptor coactivator 1

Associated with

Bile acid and bile salt metabolism
(R-MMU-194068)
Biological oxidations
(R-MMU-211859)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Chromatin modifying enzymes
(R-MMU-3247509)
Chromatin organization
(R-MMU-4839726)
Cytochrome p450 - arranged by substrate type
(R-MMU-211897)
Cytoprotection by hmox1
(R-MMU-9707564)
Endogenous sterols
(R-MMU-211976)
Esr-mediated signaling
(R-MMU-8939211)
Estrogen-dependent gene expression
(R-MMU-9018519)
Hats acetylate histones
(R-MMU-3214847)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of proteins
(R-MMU-392499)
Metabolism of steroids
(R-MMU-8957322)
Nr1h2 & nr1h3 regulate gene expression to control bile acid homeostasis
(R-MMU-9623433)
Nr1h2 and nr1h3-mediated signaling
(R-MMU-9024446)
Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux
(R-MMU-9029569)
Phase i - functionalization of compounds
(R-MMU-211945)
Post-translational protein modification
(R-MMU-597592)
Recycling of bile acids and salts
(R-MMU-159418)
Regulation of lipid metabolism by pparalpha
(R-MMU-400206)
Signaling by nuclear receptors
(R-MMU-9006931)
Signal transduction
(R-MMU-162582)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of transcription cofactors
(R-MMU-3899300)
Synthesis of bile acids and bile salts
(R-MMU-192105)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
(R-MMU-193368)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
(R-MMU-193807)
Acyltransferase activity
(GO:0016746)
Cellular response to hormone stimulus
(GO:0032870)
Cellular response to thyroglobulin triiodothyronine
(GO:1904017)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Cytosol
(GO:0005829)
Dna binding
(GO:0003677)
Histone acetyltransferase activity
(GO:0004402)
Labyrinthine layer morphogenesis
(GO:0060713)
Male mating behavior
(GO:0060179)
Mrna transcription by rna polymerase ii
(GO:0042789)
Nuclear estrogen receptor binding
(GO:0030331)
Nuclear receptor binding
(GO:0016922)
Nuclear receptor coactivator activity
(GO:0030374)
Nuclear retinoic acid receptor binding
(GO:0042974)
Nuclear retinoid x receptor binding
(GO:0046965)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peroxisome proliferator activated receptor signaling pathway
(GO:0035357)
Plasma membrane
(GO:0005886)
Positive regulation of adipose tissue development
(GO:1904179)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of female receptivity
(GO:0045925)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription from rna polymerase ii promoter by galactose
(GO:0000435)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Regulation of cellular response to insulin stimulus
(GO:1900076)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of thyroid hormone mediated signaling pathway
(GO:0002155)
Response to estradiol
(GO:0032355)
Response to progesterone
(GO:0032570)
Response to retinoic acid
(GO:0032526)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Transcription coactivator activity
(GO:0003713)
Transcription regulator complex
(GO:0005667)
Transferase activity
(GO:0016740)

Other Information

Proteins

Nuclear receptor coactivator 1

Genular Protein ID: 3309051336

Symbol: NCOA1_MOUSE

Name: Nuclear receptor coactivator 1

UniProtKB Accession Codes:

P70365 P70366 Q61202 Q66JL7 Q8CBI9

Database IDs:

Citations:

PubMed ID: 8616895

Title: A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors.

PubMed ID: 8616895

DOI: 10.1016/s0092-8674(00)81118-6

PubMed ID: 9041124

Title: Cloning and identification of mouse steroid receptor coactivator-1 (mSRC-1), as a coactivator of peroxisome proliferator-activated receptor gamma.

PubMed ID: 9041124

PubMed ID: 8855229

Title: The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.

PubMed ID: 8855229

DOI: 10.1073/pnas.93.20.10626

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9192892

Title: The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function.

PubMed ID: 9192892

DOI: 10.1038/42652

PubMed ID: 9506940

Title: Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene.

PubMed ID: 9506940

DOI: 10.1126/science.279.5358.1922

PubMed ID: 10381882

Title: Regulation of transcription by a protein methyltransferase.

PubMed ID: 10381882

DOI: 10.1126/science.284.5423.2174

PubMed ID: 12507421

Title: SRC-1 and TIF2 control energy balance between white and brown adipose tissues.

PubMed ID: 12507421

DOI: 10.1016/s0092-8674(02)01169-8

PubMed ID: 12709428

Title: The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine.

PubMed ID: 12709428

DOI: 10.1074/jbc.m300088200

PubMed ID: 16148126

Title: RORgammat recruits steroid receptor coactivators to ensure thymocyte survival.

PubMed ID: 16148126

DOI: 10.4049/jimmunol.175.6.3800

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 14757047

Title: Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain.

PubMed ID: 14757047

DOI: 10.1016/j.jmb.2003.12.057

Sequence Information:

Length: 1447
Mass: 157016
Checksum: 65C08AFFCF14241D
Sequence:

MSGLGDSSSD PANPDSHKRK GSPCDTLASS TEKRRREQEN KYLEELAELL SANISDIDSL 
SVKPDKCKIL KKTVDQIQLM KRMEQEKSTT DDDVQKSDIS SSSQGVIEKE SLGPLLLEAL 
DGFFFVVNCE GRIVFVSENV TSYLGYNQEE LMNTSVYSIL HVGDHAEFVK NLLPKSLVNG 
VPWPQEATRR NSHTFNCRML IHPPEDPGTE NQEACQRYEV MQCFTVSQPK SIQEDGEDFQ 
SCLICIARRL PRPPAITGVE SFMTKQDTTG KIISIDTSSL RAAGRTGWED LVRKCIYAFF 
QPQGREPSYA RQLFQEVMTR GTASSPSYRF ILNDGTMLSA HTKCKLCYPQ SPDMQPFIMG 
IHIIDREHSG LSPQDDSNSG MSIPRINPSV NPGISPAHGV TRSSTLPPSN NNMVSARVNR 
QQSSDLNSSS SHTNSSNNQG NFGCSPGNQI VANVALNQGQ AGSQSSNPSL NLNNSPMEGT 
GIALSQFMSP RRQANSGLAT RARMSNNSFP PNIPTLSSPV GITSGACNNN NRSYSNIPVT 
SLQGMNEGPN NSVGFSAGSP VLRQMSSQNS PSRLSMQPAK AESKDSKEIA SILNEMIQSD 
NSDNSANEGK PLDSGLLHNN DRLSEGDSKY SQTSHKLVQL LTTTAEQQLR HADIDTSCKD 
VLSCTGTSSS ASSNPSGGTC PSSHSSLTER HKILHRLLQE GSPSDITTLS VEPEKKDSVP 
ASTAVSVSGQ SQGSASIKLE LDAAKKKESK DHQLLRYLLD KDEKDLRSTP NLCLDDVKVK 
VEKKEQMDPC NTNPTPMTKP APEEVKLESQ SQFTADLDQF DQLLPTLEKA AQLPSLCETD 
RMDGAVTGVS IKAEVLPASL QPTTARAAPR LSRLPELELE AIDNQFGQPG AGDQIPWANN 
TLTTINQNKP EDQCISSQLD ELLCPPTTVE GRNDEKALLE QLVSFLSGKD ETELAELDRA 
LGIDKLVQGG GLDVLSERFP PQQATPPLMM EDRPTLYSQP YSSPSPTAGL SGPFQGMVRQ 
KPSLGAMPVQ VTPPRGTFSP NMGMQPRQTL NRPPAAPNQL RLQLQQRLQG QQQLMHQNRQ 
AILNQFAANA PVGMNMRSGM QQQITPQPPL NAQMLAQRQR ELYSQQHRQR QIIQQQRAML 
MRHQSFGNNI PPSSGLPVQM GTPRLPQGAP QQFPYPPNYG TNPGTPPAST SPFSQLAANP 
EASLATRSSM VNRGMAGNMG GQFGAGISPQ MQQNVFQYPG PGLVPQGEAT FAPSLSPGSS 
MVPMPVPPPQ SSLLQQTPPT SGYQSPDMKA WQQGTMGNNN VFSQAVQSQP APAQPGVYNN 
MSITVSMAGG NANIQNMNPM MGQMQMSSLQ MPGMNTVCSE QMNDPALRHT GLYCNQLSST 
DLLKTDADGN QQVQQVQVFA DVQCTVNLVG GDPYLNQPGP LGTQKPTSGP QTPQAQQKSL 
LQQLLTE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ncoa1

Associated with

Other Information

A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. PubMed ID: 8616895

Cloning and identification of mouse steroid receptor coactivator-1 (mSRC-1), as a coactivator of peroxisome proliferator-activated receptor gamma. PubMed ID: 9041124

The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. PubMed ID: 8855229

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. PubMed ID: 9192892

Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene. PubMed ID: 9506940

Regulation of transcription by a protein methyltransferase. PubMed ID: 10381882

SRC-1 and TIF2 control energy balance between white and brown adipose tissues. PubMed ID: 12507421

The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine. PubMed ID: 12709428

RORgammat recruits steroid receptor coactivators to ensure thymocyte survival. PubMed ID: 16148126

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain. PubMed ID: 14757047