Genular: Defining Cellular Identity and Function

Details for: Ndp

Gene ID: 17986

Symbol: Ndp

Ensembl ID: ENSMUSG00000040138

Description: Norrie disease (pseudoglioma) (human)

Associated with

Action potential
(GO:0001508)
Angiogenesis
(GO:0001525)
Blood vessel remodeling
(GO:0001974)
Canonical wnt signaling pathway
(GO:0060070)
Cell population proliferation
(GO:0008283)
Cell surface
(GO:0009986)
Cellular response to hypoxia
(GO:0071456)
Collagen-containing extracellular matrix
(GO:0062023)
Cone retinal bipolar cell differentiation
(GO:1904390)
Cytokine activity
(GO:0005125)
Dendrite development
(GO:0016358)
Dendritic spine development
(GO:0060996)
Endothelial cell differentiation
(GO:0045446)
Establishment of blood-brain barrier
(GO:0060856)
Establishment of blood-retinal barrier
(GO:1990963)
Exploration behavior
(GO:0035640)
Extracellular matrix-cell signaling
(GO:0035426)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Frizzled binding
(GO:0005109)
Gene expression
(GO:0010467)
Glutathione metabolic process
(GO:0006749)
Glycine metabolic process
(GO:0006544)
Inflammatory response
(GO:0006954)
Lens development in camera-type eye
(GO:0002088)
Microglia differentiation
(GO:0014004)
Microglial cell proliferation
(GO:0061518)
Mitotic cell cycle
(GO:0000278)
Neural retina development
(GO:0003407)
Neuron apoptotic process
(GO:0051402)
Neuron differentiation
(GO:0030182)
Norrin signaling pathway
(GO:0110135)
Optic nerve development
(GO:0021554)
Placenta development
(GO:0001890)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Protein homodimerization activity
(GO:0042803)
Protein localization
(GO:0008104)
Protein phosphorylation
(GO:0006468)
Protein targeting to lysosome
(GO:0006622)
Protein ubiquitination
(GO:0016567)
Re-entry into mitotic cell cycle
(GO:0000320)
Response to axon injury
(GO:0048678)
Response to hypoxia
(GO:0001666)
Retina blood vessel maintenance
(GO:0097601)
Retina development in camera-type eye
(GO:0060041)
Retina layer formation
(GO:0010842)
Retinal blood vessel morphogenesis
(GO:0061304)
Retinal ganglion cell axon guidance
(GO:0031290)
Retinal pigment epithelium development
(GO:0003406)
Retinal rod cell differentiation
(GO:0060221)
Retina morphogenesis in camera-type eye
(GO:0060042)
Retina vasculature development in camera-type eye
(GO:0061298)
Retina vasculature morphogenesis in camera-type eye
(GO:0061299)
Serine family amino acid metabolic process
(GO:0009069)
Smoothened signaling pathway
(GO:0007224)
Transcription by rna polymerase ii
(GO:0006366)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Tricarboxylic acid cycle
(GO:0006099)
Ubiquitin-dependent endocytosis
(GO:0070086)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

Norrin

Genular Protein ID: 2819024547

Symbol: NDP_MOUSE

Name: Norrin

UniProtKB Accession Codes:

P48744 Q5CZY6

Database IDs:

Citations:

PubMed ID: 8789439

Title: An animal model for Norrie disease (ND): gene targeting of the mouse ND gene.

PubMed ID: 8789439

DOI: 10.1093/hmg/5.1.51

PubMed ID: 8835523

Title: Characterization and mapping of the mouse NDP (Norrie disease) locus (Ndp).

PubMed ID: 8835523

DOI: 10.1007/s003359900026

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10452356

Title: Localization of the Norrie disease gene mRNA by in situ hybridization.

PubMed ID: 10452356

DOI: 10.1016/s0361-9230(99)00071-4

PubMed ID: 15035989

Title: Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair.

PubMed ID: 15035989

DOI: 10.1016/s0092-8674(04)00216-8

PubMed ID: 19837033

Title: TSPAN12 regulates retinal vascular development by promoting Norrin-but not Wnt-induced FZD4/beta-catenin signaling.

PubMed ID: 19837033

DOI: 10.1016/j.cell.2009.07.048

Sequence Information:

Length: 131
Mass: 14700
Checksum: A761D508AED1D1A3
Sequence:

MRNHVLAASI SMLSLLAIMG DTDSKTDSSF LMDSQRCMRH HYVDSISHPL YKCSSKMVLL 
ARCEGHCSQA SRSEPLVSFS TVLKQPFRSS CHCCRPQTSK LKALRLRCSG GMRLTATYRY 
ILSCHCEECS S

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ndp

Associated with

Other Information

An animal model for Norrie disease (ND): gene targeting of the mouse ND gene. PubMed ID: 8789439

Characterization and mapping of the mouse NDP (Norrie disease) locus (Ndp). PubMed ID: 8835523

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Localization of the Norrie disease gene mRNA by in situ hybridization. PubMed ID: 10452356

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. PubMed ID: 15035989