Genular: Defining Cellular Identity and Function

Details for: Nedd4

Gene ID: 17999

Symbol: Nedd4

Ensembl ID: ENSMUSG00000032216

Description: neural precursor cell expressed, developmentally down-regulated 4

Associated with

Adaptive immune system
(R-MMU-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-MMU-983168)
Antiviral mechanism by ifn-stimulated genes
(R-MMU-1169410)
Class i mhc mediated antigen processing & presentation
(R-MMU-983169)
Cytokine signaling in immune system
(R-MMU-1280215)
Downregulation of erbb4 signaling
(R-MMU-1253288)
Immune system
(R-MMU-168256)
Interferon signaling
(R-MMU-913531)
Intracellular signaling by second messengers
(R-MMU-9006925)
Isg15 antiviral mechanism
(R-MMU-1169408)
Pip3 activates akt signaling
(R-MMU-1257604)
Pten regulation
(R-MMU-6807070)
Regulation of pten localization
(R-MMU-8948747)
Regulation of pten stability and activity
(R-MMU-8948751)
Signaling by erbb4
(R-MMU-1236394)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Adaptive immune response
(GO:0002250)
Beta-2 adrenergic receptor binding
(GO:0031698)
Blood vessel morphogenesis
(GO:0048514)
Cell cortex
(GO:0005938)
Cellular response to uv
(GO:0034644)
Chromatin
(GO:0000785)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dendritic spine
(GO:0043197)
Dna damage response
(GO:0006974)
Endocardial cushion development
(GO:0003197)
Enzyme binding
(GO:0019899)
Establishment of localization in cell
(GO:0051649)
Formation of structure involved in a symbiotic process
(GO:0044111)
Glucocorticoid receptor signaling pathway
(GO:0042921)
Glutamatergic synapse
(GO:0098978)
Golgi apparatus
(GO:0005794)
Innate immune response
(GO:0045087)
Ionotropic glutamate receptor binding
(GO:0035255)
Lysosomal transport
(GO:0007041)
Membrane
(GO:0016020)
Microvillus
(GO:0005902)
Negative regulation of sodium ion transmembrane transporter activity
(GO:2000650)
Negative regulation of sodium ion transport
(GO:0010766)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of vascular endothelial growth factor receptor signaling pathway
(GO:0030948)
Nervous system development
(GO:0007399)
Neuromuscular junction development
(GO:0007528)
Neuron projection development
(GO:0031175)
Nucleus
(GO:0005634)
Outflow tract morphogenesis
(GO:0003151)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphoserine residue binding
(GO:0050815)
Phosphothreonine residue binding
(GO:0050816)
Plasma membrane
(GO:0005886)
Positive regulation of nucleocytoplasmic transport
(GO:0046824)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein catabolic process
(GO:0045732)
Progesterone receptor signaling pathway
(GO:0050847)
Proline-rich region binding
(GO:0070064)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein k63-linked ubiquitination
(GO:0070534)
Protein monoubiquitination
(GO:0006513)
Protein targeting to lysosome
(GO:0006622)
Protein ubiquitination
(GO:0016567)
Receptor catabolic process
(GO:0032801)
Receptor internalization
(GO:0031623)
Regulation of dendrite morphogenesis
(GO:0048814)
Regulation of membrane potential
(GO:0042391)
Regulation of monoatomic ion transmembrane transport
(GO:0034765)
Regulation of postsynaptic neurotransmitter receptor internalization
(GO:0099149)
Regulation of potassium ion transmembrane transporter activity
(GO:1901016)
Regulation of protein catabolic process at postsynapse, modulating synaptic transmission
(GO:0099576)
Regulation of synapse organization
(GO:0050807)
Regulation protein catabolic process at postsynapse
(GO:0140252)
Rna polymerase binding
(GO:0070063)
Sodium channel inhibitor activity
(GO:0019871)
Sodium ion transport
(GO:0006814)
T cell activation
(GO:0042110)
Transferase activity
(GO:0016740)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
(GO:0043162)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin binding
(GO:0043130)
Ubiquitin ligase complex
(GO:0000151)
Ubiquitin protein ligase activity
(GO:0061630)
Viral budding
(GO:0046755)

Other Information

Proteins

E3 ubiquitin-protein ligase NEDD4

Genular Protein ID: 1404760621

Symbol: NEDD4_MOUSE

Name: E3 ubiquitin-protein ligase NEDD4

UniProtKB Accession Codes:

P46935 O08758 Q3UZI2 Q8BGB3

Database IDs:

Citations:

PubMed ID: 1378265

Title: Identification of a set of genes with developmentally down-regulated expression in the mouse brain.

PubMed ID: 1378265

DOI: 10.1016/0006-291x(92)91747-e

PubMed ID: 9182527

Title: Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases.

PubMed ID: 9182527

DOI: 10.1074/jbc.272.24.15085

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 12693553

Title: Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PubMed ID: 12693553

DOI: 10.1093/dnares/10.1.35

PubMed ID: 9407065

Title: The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled.

PubMed ID: 9407065

DOI: 10.1074/jbc.272.52.32869

PubMed ID: 11042109

Title: Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4.

PubMed ID: 11042109

DOI: 10.1042/bj3510557

PubMed ID: 12697834

Title: The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor.

PubMed ID: 12697834

DOI: 10.1128/mcb.23.9.3363-3372.2003

PubMed ID: 15060076

Title: Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation.

PubMed ID: 15060076

DOI: 10.1074/jbc.m311802200

PubMed ID: 15908698

Title: Tsg101 and Alix interact with murine leukemia virus Gag and cooperate with Nedd4 ubiquitin ligases during budding.

PubMed ID: 15908698

DOI: 10.1074/jbc.m413735200

PubMed ID: 16452087

Title: Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

PubMed ID: 16452087

DOI: 10.1074/mcp.t500041-mcp200

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18286479

Title: Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization.

PubMed ID: 18286479

DOI: 10.1002/jcp.21405

PubMed ID: 19193720

Title: Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cells.

PubMed ID: 19193720

DOI: 10.1096/fj.08-121947

PubMed ID: 19047365

Title: The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation.

PubMed ID: 19047365

DOI: 10.1128/mcb.00595-08

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20159449

Title: Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development.

PubMed ID: 20159449

DOI: 10.1016/j.neuron.2010.01.007

PubMed ID: 20980250

Title: Structural basis for the interaction between the growth factor-binding protein GRB10 and the E3 ubiquitin ligase NEDD4.

PubMed ID: 20980250

DOI: 10.1074/jbc.m110.143412

PubMed ID: 28784777

Title: Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis.

PubMed ID: 28784777

DOI: 10.1073/pnas.1703494114

Sequence Information:

Length: 887
Mass: 102706
Checksum: AE7DD3ED63986C50
Sequence:

MSSDMAADES EAPVLSEDEV WEFCLDKTED GGGSPGSDVT DTCEPPCGCW ELNPNSLEEE 
HVLFTADPYL ELHNDDTRVV RVKVIAGIGL AKKDILGASD PYVRVTLYDP MSGILTSVQT 
KTIKKSLNPK WNEEILFRVL PQRHRILFEV FDENRLTRDD FLGQVDVPLY PLPTENPRME 
RPYTFKDFVL HPRSHKSRVK GYLRLKMTYL PKNGSEDENA DQAEELEPGW VVLDQPDAAT 
HLPHPPEPSP LPPGWEERQD VLGRTYYVNH ESRRTQWKRP SPDDDLTDED NDDMQLQAQR 
AFTTRRQISE DVDGPDNRES PENWEIVRED ENTEYSGQAV QSPPSGHIDV QTHLAEEFNT 
RLAVCGNPAT SQPVTSSNHS SRGGSLQTCI FEEQPTLPVL LPTSSGLPPG WEEKQDDRGR 
SYYVDHNSKT TTWSKPTMQD DPRSKIPAHL RGKTDSNDLG PLPPGWEERT HTDGRVFFIN 
HNIKKTQWED PRLQNVAITG PAVPYSRDYK RKYEFFRRKL KKQTDIPNKF EMKLRRANIL 
EDSYRRIMGV KRADLLKARL WIEFDGEKGL DYGGVAREWF FLISKEMFNP YYGLFEYSAT 
DNYTLQINPN SGLCNEDHLS YFKFIGRVAG MAVYHGKLLD GFFIRPFYKM MLQKLITLHD 
MESVDSEYYS SLRWILENDP TELDLRFIID EELFGQTHQH ELKTGGSEIV VTNKNKKEYI 
YLVIQWRFVN RIQKQMAAFK EGFFELIPQD LIKIFDENEL ELLMCGLGDV DVNDWREHTK 
YKNGYSMNHQ VIHWFWKAVW MMDSEKRIRL LQFVTGTSRV PMNGFAELYG SNGPQSFTVE 
QWGTPDKLPR AHTCFNRLDL PPYESFDELW DKLQMAIENT QGFDGVD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nedd4

Associated with

Other Information

Identification of a set of genes with developmentally down-regulated expression in the mouse brain. PubMed ID: 1378265

Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases. PubMed ID: 9182527

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. PubMed ID: 12693553

The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled. PubMed ID: 9407065

Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4. PubMed ID: 11042109

The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor. PubMed ID: 12697834

Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation. PubMed ID: 15060076

Tsg101 and Alix interact with murine leukemia virus Gag and cooperate with Nedd4 ubiquitin ligases during budding. PubMed ID: 15908698

Comprehensive identification of phosphorylation sites in postsynaptic density preparations. PubMed ID: 16452087

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization. PubMed ID: 18286479

Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cells. PubMed ID: 19193720

The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation. PubMed ID: 19047365

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development. PubMed ID: 20159449

Structural basis for the interaction between the growth factor-binding protein GRB10 and the E3 ubiquitin ligase NEDD4. PubMed ID: 20980250

Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis. PubMed ID: 28784777