Genular: Defining Cellular Identity and Function

Details for: Nek2

Gene ID: 18005

Symbol: Nek2

Ensembl ID: ENSMUSG00000026622

Description: NIMA (never in mitosis gene a)-related expressed kinase 2

Associated with

Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-MMU-176814)
Anchoring of the basal body to the plasma membrane
(R-MMU-5620912)
Apc-cdc20 mediated degradation of nek2a
(R-MMU-179409)
Apc/c-mediated degradation of cell cycle proteins
(R-MMU-174143)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-MMU-176409)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-MMU-179419)
Aurka activation by tpx2
(R-MMU-8854518)
Cell cycle, mitotic
(R-MMU-69278)
Centrosome maturation
(R-MMU-380287)
Cilium assembly
(R-MMU-5617833)
G2/m transition
(R-MMU-69275)
Loss of nlp from mitotic centrosomes
(R-MMU-380259)
Loss of proteins required for interphase microtubule organization from the centrosome
(R-MMU-380284)
Mitotic g2-g2/m phases
(R-MMU-453274)
Mitotic prometaphase
(R-MMU-68877)
M phase
(R-MMU-68886)
Organelle biogenesis and maintenance
(R-MMU-1852241)
Recruitment of mitotic centrosome proteins and complexes
(R-MMU-380270)
Recruitment of numa to mitotic centrosomes
(R-MMU-380320)
Regulation of mitotic cell cycle
(R-MMU-453276)
Regulation of plk1 activity at g2/m transition
(R-MMU-2565942)
Atp binding
(GO:0005524)
Blastocyst development
(GO:0001824)
Cell cycle
(GO:0007049)
Cell division
(GO:0051301)
Centrosome
(GO:0005813)
Centrosome separation
(GO:0051299)
Chromosome
(GO:0005694)
Chromosome, centromeric region
(GO:0000775)
Chromosome segregation
(GO:0007059)
Condensed nuclear chromosome
(GO:0000794)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Kinase activity
(GO:0016301)
Kinetochore
(GO:0000776)
Meiotic cell cycle
(GO:0051321)
Metal ion binding
(GO:0046872)
Microtubule
(GO:0005874)
Midbody
(GO:0030496)
Mitotic sister chromatid segregation
(GO:0000070)
Mitotic spindle assembly
(GO:0090307)
Negative regulation of centriole-centriole cohesion
(GO:1903126)
Negative regulation of dna binding
(GO:0043392)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Phosphorylation
(GO:0016310)
Positive regulation of telomerase activity
(GO:0051973)
Positive regulation of telomere capping
(GO:1904355)
Positive regulation of telomere maintenance via telomerase
(GO:0032212)
Protein-containing complex
(GO:0032991)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphatase binding
(GO:0019903)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of attachment of spindle microtubules to kinetochore
(GO:0051988)
Regulation of mitotic centrosome separation
(GO:0046602)
Spindle pole
(GO:0000922)
Transferase activity
(GO:0016740)

Other Information

Proteins

Serine/threonine-protein kinase Nek2
Q6PFG1_MOUSE

Genular Protein ID: 2015522723

Symbol: NEK2_MOUSE

Name: Serine/threonine-protein kinase Nek2

UniProtKB Accession Codes:

O35942 O35959 Q3TPD7

Database IDs:

Citations:

PubMed ID: 9187143

Title: The NIMA-related kinase 2, Nek2, is expressed in specific stages of the meiotic cell cycle and associates with meiotic chromosomes.

PubMed ID: 9187143

DOI: 10.1242/dev.124.11.2167

PubMed ID: 9583679

Title: Murine NIMA-related kinases are expressed in patterns suggesting distinct functions in gametogenesis and a role in the nervous system.

PubMed ID: 9583679

DOI: 10.1038/sj.onc.1201710

PubMed ID: 9434622

Title: The in vivo expression pattern of mouse Nek2, a NIMA-related kinase, indicates a role in both mitosis and meiosis.

PubMed ID: 9434622

DOI: 10.1006/excr.1997.3788

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 14697346

Title: NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi.

PubMed ID: 14697346

DOI: 10.1016/j.yexcr.2003.09.025

PubMed ID: 14668482

Title: Phosphorylation of high-mobility group protein A2 by Nek2 kinase during the first meiotic division in mouse spermatocytes.

PubMed ID: 14668482

DOI: 10.1091/mbc.e03-09-0638

Sequence Information:

Length: 443
Mass: 51243
Checksum: 1EF2CA320F60FB5C
Sequence:

MPSRVEDYEV LHSIGTGSYG RCQKIRRKSD GKILVWKELD YGSMTEVEKQ MLVSEVNLLR 
ELKHPNIVSY YDRIIDRTNT TLYIVMEYCE GGDLASVISK GTKDRQYLEE EFVLRVMTQL 
TLALKECHRR SDGGHTVLHR DLKPANVFLD SKHNVKLGDF GLARILNHDT SFAKTFVGTP 
YYMSPEQMSC LSYNEKSDIW SLGCLLYELC ALMPPFTAFN QKELAGKIRE GRFRRIPYRY 
SDGLNDLITR MLNLKDYHRP SVEEILESPL IADLVAEEQR RNLERRGRRS GEPSKLPDSS 
PVLSELKLKE RQLQDREQAL RAREDILEQK ERELCIRERL AEDKLARAES LMKNYSLLKE 
HRLLCLAGGP ELDLPSSAMK KKVHFHGESK ENTARSENSE SYLAKSKCRD LKKRLHAAQL 
RAQALADIEK NYQLKSRQIL GMR

Genular Protein ID: 902459220

Symbol: Q6PFG1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q6PFG1

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 443
Mass: 51253
Checksum: B1F2CA320F620673
Sequence:

MPSRVEDYEV LHSIGTGSYG RCQKIRRKSD GKILVWKELD YGSMTEVEKQ MLVSEVNLLR 
ELKHPNIVSY YDRIIDRTNT TLYIVMEYCE GGDLASVISK GTKDRQYLEE EFVLRVMTQL 
TLALKECHRR SDGGHTVLHR DLKPANVFLD SKHNVKLGDF GLARILNHDT SFAKTFVGTP 
YYMSPEQMSC LSYNEKSDIW SLGCLLYELC ALMPPFTAFN QKELAGKIRE GRFRRIPYRY 
SDGLNDLITR MLNLKDYHRP SVEEILESPL IADLVAEEQR RNLERRGRRS GEPSKLPDSS 
PVLSELKLKE RQLQDREQAL RAREDILEQK ERELCIRERL AEDKLARAES LMKNYSLLKE 
HRLLCLAGGP ELDLPSSAMK KKVHFHGESK ENTARSENSE SYLAKPKCRD LKKRLHAAQL 
RAQALADIEK NYQLKSRQIL GMR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nek2

Associated with

Other Information

The NIMA-related kinase 2, Nek2, is expressed in specific stages of the meiotic cell cycle and associates with meiotic chromosomes. PubMed ID: 9187143

Murine NIMA-related kinases are expressed in patterns suggesting distinct functions in gametogenesis and a role in the nervous system. PubMed ID: 9583679

The in vivo expression pattern of mouse Nek2, a NIMA-related kinase, indicates a role in both mitosis and meiosis. PubMed ID: 9434622

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi. PubMed ID: 14697346

Phosphorylation of high-mobility group protein A2 by Nek2 kinase during the first meiotic division in mouse spermatocytes. PubMed ID: 14668482

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334