Genular: Defining Cellular Identity and Function

Details for: Neu1

Gene ID: 18010

Symbol: Neu1

Ensembl ID: ENSMUSG00000007038

Description: neuraminidase 1

Associated with

Asparagine n-linked glycosylation
(R-MMU-446203)
Biosynthesis of the n-glycan precursor (dolichol lipid-linked oligosaccharide, llo) and transfer to a nascent protein
(R-MMU-446193)
Glycosphingolipid catabolism
(R-MMU-9840310)
Glycosphingolipid metabolism
(R-MMU-1660662)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of proteins
(R-MMU-392499)
Neutrophil degranulation
(R-MMU-6798695)
Post-translational protein modification
(R-MMU-597592)
Sialic acid metabolism
(R-MMU-4085001)
Sphingolipid metabolism
(R-MMU-428157)
Synthesis of substrates in n-glycan biosythesis
(R-MMU-446219)
Alpha-sialidase activity
(GO:0016997)
Carbohydrate metabolic process
(GO:0005975)
Cell junction
(GO:0030054)
Cell surface
(GO:0009986)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Exo-alpha-(2->3)-sialidase activity
(GO:0052794)
Exo-alpha-(2->6)-sialidase activity
(GO:0052795)
Exo-alpha-(2->8)-sialidase activity
(GO:0052796)
Exo-alpha-sialidase activity
(GO:0004308)
Ganglioside catabolic process
(GO:0006689)
Hydrolase activity
(GO:0016787)
Hydrolase activity, acting on glycosyl bonds
(GO:0016798)
Intracellular membrane-bounded organelle
(GO:0043231)
Lipid catabolic process
(GO:0016042)
Lipid metabolic process
(GO:0006629)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Metabolic process
(GO:0008152)
Oligosaccharide catabolic process
(GO:0009313)
Plasma membrane
(GO:0005886)
Positive regulation of neuron projection development
(GO:0010976)
Protein binding
(GO:0005515)
Regulation of myoblast proliferation
(GO:2000291)

Other Information

Proteins

Sialidase-1

Genular Protein ID: 5200508

Symbol: NEUR1_MOUSE

Name: Sialidase-1

UniProtKB Accession Codes:

O35657 O55220 Q99KG9

Database IDs:

Citations:

PubMed ID: 9363440

Title: Cloning and characterization of a sialidase from the murine histocompatibility-2 complex: low levels of mRNA and a single amino acid mutation are responsible for reduced sialidase activity in mice carrying the Neu1a allele.

PubMed ID: 9363440

DOI: 10.1093/glycob/7.7.975

PubMed ID: 9384611

Title: Cloning of the cDNA and gene encoding mouse lysosomal sialidase and correction of sialidase deficiency in human sialidosis and mouse SM/J fibroblasts.

PubMed ID: 9384611

DOI: 10.1093/hmg/7.1.115

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 9425240

Title: A point mutation in the neu-1 locus causes the neuraminidase defect in the SM/J mouse.

PubMed ID: 9425240

DOI: 10.1093/hmg/7.2.313

Sequence Information:

Length: 409
Mass: 44591
Checksum: 416BFD5BE27B8893
Sequence:

MVGADPTRPR GPLSYWAGRR GQGLAAIFLL LVSAAESEAR AEDDFSLVQP LVTMEQLLWV 
SGKQIGSVDT FRIPLITATP RGTLLAFAEA RKKSASDEGA KFIAMRRSTD QGSTWSSTAF 
IVDDGEASDG LNLGAVVNDV DTGIVFLIYT LCAHKVNCQV ASTMLVWSKD DGISWSPPRN 
LSVDIGTEMF APGPGSGIQK QREPGKGRLI VCGHGTLERD GVFCLLSDDH GASWHYGTGV 
SGIPFGQPKH DHDFNPDECQ PYELPDGSVI INARNQNNYH CRCRIVLRSY DACDTLRPRD 
VTFDPELVDP VVAAGALATS SGIVFFSNPA HPEFRVNLTL RWSFSNGTSW QKERVQVWPG 
PSGYSSLTAL ENSTDGKKQP PQLFVLYEKG LNRYTESISM VKISVYGTL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Neu1

Associated with

Other Information

Cloning and characterization of a sialidase from the murine histocompatibility-2 complex: low levels of mRNA and a single amino acid mutation are responsible for reduced sialidase activity in mice carrying the Neu1a allele. PubMed ID: 9363440

Cloning of the cDNA and gene encoding mouse lysosomal sialidase and correction of sialidase deficiency in human sialidosis and mouse SM/J fibroblasts. PubMed ID: 9384611

Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. PubMed ID: 14656967

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079