Genular: Defining Cellular Identity and Function

Details for: Neurod1

Gene ID: 18012

Symbol: Neurod1

Ensembl ID: ENSMUSG00000034701

Description: neurogenic differentiation 1

Associated with

Amacrine cell differentiation
(GO:0035881)
Anterior/posterior pattern specification
(GO:0009952)
Axon development
(GO:0061564)
Camera-type eye development
(GO:0043010)
Cell differentiation
(GO:0030154)
Cell fate commitment
(GO:0045165)
Cellular response to glucose stimulus
(GO:0071333)
Cerebellum development
(GO:0021549)
Chromatin binding
(GO:0003682)
Cytoplasm
(GO:0005737)
Dentate gyrus development
(GO:0021542)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
E-box binding
(GO:0070888)
Embryonic organ morphogenesis
(GO:0048562)
Endocrine pancreas development
(GO:0031018)
Enteroendocrine cell differentiation
(GO:0035883)
Glucose homeostasis
(GO:0042593)
Hindbrain development
(GO:0030902)
Inner ear development
(GO:0048839)
Insulin secretion
(GO:0030073)
Intracellular anatomical structure
(GO:0005622)
Multicellular organism development
(GO:0007275)
Negative regulation of receptor signaling pathway via jak-stat
(GO:0046426)
Negative regulation of type b pancreatic cell apoptotic process
(GO:2000675)
Nervous system development
(GO:0007399)
Nitric oxide mediated signal transduction
(GO:0007263)
Nucleocytoplasmic transport
(GO:0006913)
Nucleus
(GO:0005634)
Pancreatic a cell fate commitment
(GO:0003326)
Pancreatic pp cell fate commitment
(GO:0003329)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cell differentiation
(GO:0045597)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription regulatory region dna binding
(GO:2000679)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Protein heterodimerization activity
(GO:0046982)
Receptor signaling pathway via jak-stat
(GO:0007259)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of intestinal epithelial structure maintenance
(GO:0060730)
Regulation of neuron differentiation
(GO:0045664)
Response to glucose
(GO:0009749)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Sensory organ development
(GO:0007423)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Signal transduction involved in regulation of gene expression
(GO:0023019)
Transcription by rna polymerase ii
(GO:0006366)

Other Information

Proteins

Neurogenic differentiation factor 1

Genular Protein ID: 3142133014

Symbol: NDF1_MOUSE

Name: Neurogenic differentiation factor 1

UniProtKB Accession Codes:

Q60867 Q545N9 Q60897

Database IDs:

Citations:

PubMed ID: 7754368

Title: Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein.

PubMed ID: 7754368

DOI: 10.1126/science.7754368

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9308961

Title: Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice.

PubMed ID: 9308961

DOI: 10.1101/gad.11.18.2323

PubMed ID: 9512516

Title: The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells.

PubMed ID: 9512516

DOI: 10.1101/gad.12.6.820

PubMed ID: 10398678

Title: NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus.

PubMed ID: 10398678

DOI: 10.1101/gad.13.13.1647

PubMed ID: 10639171

Title: Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy.

PubMed ID: 10639171

DOI: 10.1073/pnas.97.2.865

PubMed ID: 11152640

Title: NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development.

PubMed ID: 11152640

DOI: 10.1242/dev.128.3.417

PubMed ID: 11861467

Title: Math3 and NeuroD regulate amacrine cell fate specification in the retina.

PubMed ID: 11861467

DOI: 10.1242/dev.129.4.831

PubMed ID: 11970861

Title: Posttranslational mechanisms control the timing of bHLH function and regulate retinal cell fate.

PubMed ID: 11970861

DOI: 10.1016/s0896-6273(02)00666-9

PubMed ID: 12810726

Title: Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells.

PubMed ID: 12810726

DOI: 10.1074/jbc.m301198200

PubMed ID: 14697366

Title: Regulation of neuroD2 expression in mouse brain.

PubMed ID: 14697366

DOI: 10.1016/j.ydbio.2003.08.027

PubMed ID: 14752053

Title: Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD.

PubMed ID: 14752053

DOI: 10.1210/me.2003-0311

PubMed ID: 15797719

Title: Context-dependent regulation of NeuroD activity and protein accumulation.

PubMed ID: 15797719

DOI: 10.1016/j.mcn.2004.12.004

PubMed ID: 18007592

Title: Neurogenin and NeuroD direct transcriptional targets and their regulatory enhancers.

PubMed ID: 18007592

DOI: 10.1038/sj.emboj.7601923

PubMed ID: 18339630

Title: Targeted disruption of NeuroD, a proneural basic helix-loop-helix factor, impairs distal lung formation and neuroendocrine morphology in the neonatal lung.

PubMed ID: 18339630

DOI: 10.1074/jbc.m708692200

PubMed ID: 18560595

Title: Identification of the bHLH factor Math6 as a novel component of the embryonic pancreas transcriptional network.

PubMed ID: 18560595

DOI: 10.1371/journal.pone.0002430

PubMed ID: 19200230

Title: Involvement of Ngn2, Tbr and NeuroD proteins during postnatal olfactory bulb neurogenesis.

PubMed ID: 19200230

DOI: 10.1111/j.1460-9568.2008.06595.x

PubMed ID: 19759004

Title: Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3.

PubMed ID: 19759004

DOI: 10.1074/jbc.m109.048694

PubMed ID: 19854889

Title: mu-Opioid receptor agonists differentially regulate the expression of miR-190 and NeuroD.

PubMed ID: 19854889

DOI: 10.1124/mol.109.060848

PubMed ID: 21593321

Title: NeuroD factors regulate cell fate and neurite stratification in the developing retina.

PubMed ID: 21593321

DOI: 10.1523/jneurosci.2555-10.2011

PubMed ID: 23395635

Title: Tcf15 primes pluripotent cells for differentiation.

PubMed ID: 23395635

DOI: 10.1016/j.celrep.2013.01.017

PubMed ID: 18069799

Title: Crystal structure of E47-NeuroD1/beta2 bHLH domain-DNA complex: heterodimer selectivity and DNA recognition.

PubMed ID: 18069799

DOI: 10.1021/bi701527r

Sequence Information:

Length: 357
Mass: 39999
Checksum: B6626E1315E31027
Sequence:

MTKSYSESGL MGEPQPQGPP SWTDECLSSQ DEEHEADKKE DELEAMNAEE DSLRNGGEEE 
EEDEDLEEEE EEEEEEEDQK PKRRGPKKKK MTKARLERFK LRRMKANARE RNRMHGLNAA 
LDNLRKVVPC YSKTQKLSKI ETLRLAKNYI WALSEILRSG KSPDLVSFVQ TLCKGLSQPT 
TNLVAGCLQL NPRTFLPEQN PDMPPHLPTA SASFPVHPYS YQSPGLPSPP YGTMDSSHVF 
HVKPPPHAYS AALEPFFESP LTDCTSPSFD GPLSPPLSIN GNFSFKHEPS AEFEKNYAFT 
MHYPAATLAG PQSHGSIFSS GAAAPRCEIP IDNIMSFDSH SHHERVMSAQ LNAIFHD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Neurod1

Associated with

Other Information

Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. PubMed ID: 7754368

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. PubMed ID: 9308961

The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells. PubMed ID: 9512516

NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus. PubMed ID: 10398678

Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy. PubMed ID: 10639171

NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development. PubMed ID: 11152640

Math3 and NeuroD regulate amacrine cell fate specification in the retina. PubMed ID: 11861467

Posttranslational mechanisms control the timing of bHLH function and regulate retinal cell fate. PubMed ID: 11970861

Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells. PubMed ID: 12810726

Regulation of neuroD2 expression in mouse brain. PubMed ID: 14697366

Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD. PubMed ID: 14752053

Context-dependent regulation of NeuroD activity and protein accumulation. PubMed ID: 15797719

Neurogenin and NeuroD direct transcriptional targets and their regulatory enhancers. PubMed ID: 18007592

Targeted disruption of NeuroD, a proneural basic helix-loop-helix factor, impairs distal lung formation and neuroendocrine morphology in the neonatal lung. PubMed ID: 18339630

Identification of the bHLH factor Math6 as a novel component of the embryonic pancreas transcriptional network. PubMed ID: 18560595

Involvement of Ngn2, Tbr and NeuroD proteins during postnatal olfactory bulb neurogenesis. PubMed ID: 19200230

Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. PubMed ID: 19759004

mu-Opioid receptor agonists differentially regulate the expression of miR-190 and NeuroD. PubMed ID: 19854889

NeuroD factors regulate cell fate and neurite stratification in the developing retina. PubMed ID: 21593321

Tcf15 primes pluripotent cells for differentiation. PubMed ID: 23395635

Crystal structure of E47-NeuroD1/beta2 bHLH domain-DNA complex: heterodimer selectivity and DNA recognition. PubMed ID: 18069799