Genular: Defining Cellular Identity and Function

Details for: Nfe2

Gene ID: 18022

Symbol: Nfe2

Ensembl ID: ENSMUSG00000058794

Description: nuclear factor, erythroid derived 2

Associated with

Bone mineralization
(GO:0030282)
Cell-cell signaling
(GO:0007267)
Cell population proliferation
(GO:0008283)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Cytoplasm
(GO:0005737)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Gene expression
(GO:0010467)
Identical protein binding
(GO:0042802)
Labyrinthine layer blood vessel development
(GO:0060716)
Negative regulation of bone mineralization
(GO:0030502)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of syncytium formation by plasma membrane fusion
(GO:0034242)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of peptidyl-lysine acetylation
(GO:2000758)
Protein-dna complex
(GO:0032993)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Sequence-specific double-stranded dna binding
(GO:1990837)
Syncytium formation by plasma membrane fusion
(GO:0000768)
Ww domain binding
(GO:0050699)

Other Information

Proteins

Transcription factor NF-E2 45 kDa subunit
A0A0R4J0Y5_MOUSE

Genular Protein ID: 1283790864

Symbol: NFE2_MOUSE

Name: Transcription factor NF-E2 45 kDa subunit

UniProtKB Accession Codes:

Q07279 Q6P6K5

Database IDs:

Citations:

PubMed ID: 8469283

Title: Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein.

PubMed ID: 8469283

DOI: 10.1038/362722a0

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9171106

Title: Multiple regions of p45 NF-E2 are required for beta-globin gene expression in erythroid cells.

PubMed ID: 9171106

DOI: 10.1093/nar/25.12.2509

PubMed ID: 9558374

Title: Regulation of the erythroid transcription factor NF-E2 by cyclic adenosine monophosphate-dependent protein kinase.

PubMed ID: 9558374

PubMed ID: 14597626

Title: A WW domain-binding motif within the activation domain of the hematopoietic transcription factor NF-E2 is essential for establishment of a tissue-specific histone modification pattern.

PubMed ID: 14597626

DOI: 10.1074/jbc.m309750200

PubMed ID: 16287851

Title: Sumoylation of p45/NF-E2: nuclear positioning and transcriptional activation of the mammalian beta-like globin gene locus.

PubMed ID: 16287851

DOI: 10.1128/mcb.25.23.10365-10378.2005

PubMed ID: 17707229

Title: Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.

PubMed ID: 17707229

DOI: 10.1016/j.molcel.2007.06.022

PubMed ID: 19966288

Title: JNK-mediated turnover and stabilization of the transcription factor p45/NF-E2 during differentiation of murine erythroleukemia cells.

PubMed ID: 19966288

DOI: 10.1073/pnas.0909153107

Sequence Information:

Length: 373
Mass: 41565
Checksum: 47E505F78B6EEB65
Sequence:

MPPCPPQQNR NRLSQLPVGE LGEMELTWQE IMSITELQGL NVPSETSFEP QAPTPYPGPL 
PPPTYCPCSI HPDAGFSLPP PSYELPASTP HVPELPYSYG NVAIPVSKPL TLSGLLNEPL 
PDHLALLDIG LPVGQPKPQE DPESDSGLSL NYSDAESLEL EGMEAGRRRS EYVDMYPVEY 
PYSLMPNSLA HPNYTLPPTE TPLALESSSG PVRAKPAVRG EAGSRDERRA LAMKIPFPTD 
KIVNLPVDDF NELLAQYPLT ESQLALVRDI RRRGKNKVAA QNCRKRKLET IVQLERELER 
LSSERERLLR ARGEADRTLE VMRQQLAELY HDIFQHLRDE SGNSYSPEEY VLQQAADGAI 
FLVPRGTKME ATD

Genular Protein ID: 3180735354

Symbol: A0A0R4J0Y5_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0R4J0Y5

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 373
Mass: 41537
Checksum: 9A9BD4D366103077
Sequence:

MPPCPPQQNR NRLSQLPVGE LGEMELTWQE IMSITELQGL NVPSETSFEP QAPTPYPGPL 
PPPTYCPCSI HPDAGFSLPP PSYELPASTP HVPELPYSYG NVAIPVSKPL TLSGLLNEPL 
PDHLALLDIG LPVGQPKPQE DPESDSGLSL NYSDAESLEL EGMEAGRRRS EYADMYPVEY 
PYSLMPNSLA HPNYTLPPTE TPLALESSSG PVRAKPAVRG EAGSRDERRA LAMKIPFPTD 
KIVNLPVDDF NELLAQYPLT ESQLALVRDI RRRGKNKVAA QNCRKRKLET IVQLERELER 
LSSERERLLR ARGEADRTLE VMRQQLAELY HDIFQHLRDE SGNSYSPEEY VLQQAADGAI 
FLVPRGTKME ATD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nfe2

Associated with

Other Information

Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. PubMed ID: 8469283

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Multiple regions of p45 NF-E2 are required for beta-globin gene expression in erythroid cells. PubMed ID: 9171106

Regulation of the erythroid transcription factor NF-E2 by cyclic adenosine monophosphate-dependent protein kinase. PubMed ID: 9558374

A WW domain-binding motif within the activation domain of the hematopoietic transcription factor NF-E2 is essential for establishment of a tissue-specific histone modification pattern. PubMed ID: 14597626

Sumoylation of p45/NF-E2: nuclear positioning and transcriptional activation of the mammalian beta-like globin gene locus. PubMed ID: 16287851

Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus. PubMed ID: 17707229

JNK-mediated turnover and stabilization of the transcription factor p45/NF-E2 during differentiation of murine erythroleukemia cells. PubMed ID: 19966288

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303