Details for: Nfe2l2

Gene ID: 18024

Symbol: Nfe2l2

Ensembl ID: ENSMUSG00000015839

Description: nuclear factor, erythroid derived 2, like 2

Associated with

  • Cellular responses to stimuli
    (R-MMU-8953897)
  • Cellular responses to stress
    (R-MMU-2262752)
  • Cellular response to chemical stress
    (R-MMU-9711123)
  • Gsk3b and btrc:cul1-mediated-degradation of nfe2l2
    (R-MMU-9762114)
  • Keap1-nfe2l2 pathway
    (R-MMU-9755511)
  • Metabolism of proteins
    (R-MMU-392499)
  • Neddylation
    (R-MMU-8951664)
  • Nuclear events mediated by nfe2l2
    (R-MMU-9759194)
  • Post-translational protein modification
    (R-MMU-597592)
  • Aflatoxin catabolic process
    (GO:0046223)
  • Cell redox homeostasis
    (GO:0045454)
  • Cellular response to angiotensin
    (GO:1904385)
  • Cellular response to copper ion
    (GO:0071280)
  • Cellular response to fluid shear stress
    (GO:0071498)
  • Cellular response to glucose starvation
    (GO:0042149)
  • Cellular response to hydrogen peroxide
    (GO:0070301)
  • Cellular response to hypoxia
    (GO:0071456)
  • Cellular response to laminar fluid shear stress
    (GO:0071499)
  • Cellular response to oxidative stress
    (GO:0034599)
  • Cellular response to tumor necrosis factor
    (GO:0071356)
  • Cellular response to xenobiotic stimulus
    (GO:0071466)
  • Centrosome
    (GO:0005813)
  • Chromatin
    (GO:0000785)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Endoplasmic reticulum unfolded protein response
    (GO:0030968)
  • Golgi apparatus
    (GO:0005794)
  • Inflammatory response
    (GO:0006954)
  • Negative regulation of cardiac muscle cell apoptotic process
    (GO:0010667)
  • Negative regulation of cellular response to hypoxia
    (GO:1900038)
  • Negative regulation of endothelial cell apoptotic process
    (GO:2000352)
  • Negative regulation of hematopoietic stem cell differentiation
    (GO:1902037)
  • Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
    (GO:1902176)
  • Negative regulation of vascular associated smooth muscle cell migration
    (GO:1904753)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Perk-mediated unfolded protein response
    (GO:0036499)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of blood coagulation
    (GO:0030194)
  • Positive regulation of blood vessel endothelial cell migration
    (GO:0043536)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of glucose import
    (GO:0046326)
  • Positive regulation of glutathione biosynthetic process
    (GO:1903788)
  • Positive regulation of neuron projection development
    (GO:0010976)
  • Positive regulation of reactive oxygen species metabolic process
    (GO:2000379)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Proteasomal ubiquitin-independent protein catabolic process
    (GO:0010499)
  • Proteasome-mediated ubiquitin-dependent protein catabolic process
    (GO:0043161)
  • Protein-dna complex
    (GO:0032993)
  • Protein binding
    (GO:0005515)
  • Protein domain specific binding
    (GO:0019904)
  • Protein ubiquitination
    (GO:0016567)
  • Regulation of cellular response to oxidative stress
    (GO:1900407)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of embryonic development
    (GO:0045995)
  • Regulation of innate immune response
    (GO:0045088)
  • Regulation of removal of superoxide radicals
    (GO:2000121)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to endoplasmic reticulum stress
    (GO:0034976)
  • Response to organic substance
    (GO:0010033)
  • Response to oxidative stress
    (GO:0006979)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulator complex
    (GO:0090575)
  • Sequence-specific dna binding
    (GO:0043565)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription coregulator binding
    (GO:0001221)
  • Transcription factor binding
    (GO:0008134)
  • Transcription regulator complex
    (GO:0005667)
  • Ubiquitin protein ligase binding
    (GO:0031625)

Other Information

Genular Protein ID: 3844809590

Symbol: NF2L2_MOUSE

Name: Nuclear factor, erythroid derived 2, like 2

UniProtKB Accession Codes:

Q60795 Q3UQK0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisProt 1 ELM 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 GO 68 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 HOGENOM 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MGI 2 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8943040

Title: NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development.

PubMed ID: 8943040

DOI: 10.1073/pnas.93.24.13943

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7726861

Title: cDNA cloning of murine Nrf 2 gene, coding for a p45 NF-E2 related transcription factor.

PubMed ID: 7726861

DOI: 10.1006/bbrc.1995.1467

PubMed ID: 9240432

Title: An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements.

PubMed ID: 9240432

DOI: 10.1006/bbrc.1997.6943

PubMed ID: 9887101

Title: Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain.

PubMed ID: 9887101

DOI: 10.1101/gad.13.1.76

PubMed ID: 11583586

Title: Cloning and characterization of the mouse polyamine-modulated factor-1 (mPMF-1) gene: an alternatively spliced homologue of the human transcription factor.

PubMed ID: 11583586

DOI: 10.1042/0264-6021:3590387

PubMed ID: 11248092

Title: Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice.

PubMed ID: 11248092

DOI: 10.1073/pnas.051618798

PubMed ID: 12032331

Title: Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors.

PubMed ID: 12032331

DOI: 10.1073/pnas.112203099

PubMed ID: 12968018

Title: Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress.

PubMed ID: 12968018

DOI: 10.1074/jbc.m308439200

PubMed ID: 14517554

Title: Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation.

PubMed ID: 14517554

DOI: 10.1038/ng1248

PubMed ID: 15282312

Title: Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.

PubMed ID: 15282312

DOI: 10.1128/mcb.24.16.7130-7139.2004

PubMed ID: 15367669

Title: The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase.

PubMed ID: 15367669

DOI: 10.1128/mcb.24.19.8477-8486.2004

PubMed ID: 15581590

Title: Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome.

PubMed ID: 15581590

DOI: 10.1016/j.abb.2004.10.012

PubMed ID: 16790436

Title: Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a 'tethering' mechanism: a two-site interaction model for the Nrf2-Keap1 complex.

PubMed ID: 16790436

DOI: 10.1074/jbc.m601119200

PubMed ID: 16585964

Title: Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis.

PubMed ID: 16585964

DOI: 10.1172/jci25790

PubMed ID: 16581765

Title: Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model.

PubMed ID: 16581765

DOI: 10.1128/mcb.26.8.2887-2900.2006

PubMed ID: 17920186

Title: ERRbeta: a potent inhibitor of Nrf2 transcriptional activity.

PubMed ID: 17920186

DOI: 10.1016/j.mce.2007.08.011

PubMed ID: 20498371

Title: The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response.

PubMed ID: 20498371

DOI: 10.1074/jbc.m110.145441

PubMed ID: 20421418

Title: A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.

PubMed ID: 20421418

DOI: 10.1128/mcb.00248-10

PubMed ID: 20173742

Title: The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.

PubMed ID: 20173742

DOI: 10.1038/ncb2021

PubMed ID: 27211851

Title: Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription.

PubMed ID: 27211851

DOI: 10.1038/ncomms11624

PubMed ID: 31398338

Title: The oncogenic action of NRF2 depends on de-glycation by fructosamine-3-kinase.

PubMed ID: 31398338

DOI: 10.1016/j.cell.2019.07.031

PubMed ID: 28842501

Title: Stress-sensing mechanisms and the physiological roles of the Keap1-Nrf2 system during cellular stress.

PubMed ID: 28842501

DOI: 10.1074/jbc.r117.800169

PubMed ID: 16507366

Title: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer.

PubMed ID: 16507366

DOI: 10.1016/j.molcel.2006.01.013

Sequence Information:

  • Length: 597
  • Mass: 66901
  • Checksum: 6128707C82CAE239
  • Sequence:
    • MMDLELPPPG LQSQQDMDLI DILWRQDIDL GVSREVFDFS QRQKDYELEK QKKLEKERQE 
QLQKEQEKAF FAQFQLDEET GEFLPIQPAQ HIQTDTSGSA SYSQVAHIPK QDALYFEDCM 
QLLAETFPFV DDHESLALDI PSHAESSVFT APHQAQSLNS SLEAAMTDLS SIEQDMEQVW 
QELFSIPELQ CLNTENKQLA DTTAVPSPEA TLTEMDSNYH FYSSISSLEK EVGNCGPHFL 
HGFEDSFSSI LSTDDASQLT SLDSNPTLNT DFGDEFYSAF IAEPSDGGSM PSSAAISQSL 
SELLDGTIEG CDLSLCKAFN PKHAEGTMEF NDSDSGISLN TSPSRASPEH SVESSIYGDP 
PPGFSDSEME ELDSAPGSVK QNGPKAQPAH SPGDTVQPLS PAQGHSAPMR ESQCENTTKK 
EVPVSPGHQK APFTKDKHSS RLEAHLTRDE LRAKALHIPF PVEKIINLPV DDFNEMMSKE 
QFNEAQLALI RDIRRRGKNK VAAQNCRKRK LENIVELEQD LGHLKDEREK LLREKGENDR 
NLHLLKRRLS TLYLEVFSML RDEDGKPYSP SEYSLQQTRD GNVFLVPKSK KPDTKKN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.