Details for: Nfil3

Gene ID: 18030

Symbol: Nfil3

Ensembl ID: ENSMUSG00000056749

Description: nuclear factor, interleukin 3, regulated

Associated with

  • Cellular response to interleukin-4
    (GO:0071353)
  • Circadian rhythm
    (GO:0007623)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna-templated transcription
    (GO:0006351)
  • Dna binding
    (GO:0003677)
  • Identical protein binding
    (GO:0042802)
  • Immune response
    (GO:0006955)
  • Natural killer cell differentiation
    (GO:0001779)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of gene expression
    (GO:0010628)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Rhythmic process
    (GO:0048511)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulator complex
    (GO:0090575)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Transcription by rna polymerase ii
    (GO:0006366)

Other Information

Genular Protein ID: 81309728

Symbol: NFIL3_MOUSE

Name: Nuclear factor interleukin-3-regulated protein

UniProtKB Accession Codes:

O08750 Q3ULK2 Q497U0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 EPD 1 Ensembl 1 GO 17 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 4 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 9122243

Title: Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes.

PubMed ID: 9122243

DOI: 10.1073/pnas.94.6.2609

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11316793

Title: Antagonistic role of E4BP4 and PAR proteins in the circadian oscillatory mechanism.

PubMed ID: 11316793

DOI: 10.1101/gad.873501

PubMed ID: 12743120

Title: Parathyroid hormone-induced E4BP4/NFIL3 down-regulates transcription in osteoblasts.

PubMed ID: 12743120

DOI: 10.1074/jbc.m212652200

PubMed ID: 15087429

Title: Parathyroid hormone induces E4bp4 messenger ribonucleic acid expression primarily through cyclic adenosine 3',5'-monophosphate signaling in osteoblasts.

PubMed ID: 15087429

DOI: 10.1210/en.2003-1436

PubMed ID: 17274955

Title: The negative transcription factor E4BP4 is associated with circadian clock protein PERIOD2.

PubMed ID: 17274955

DOI: 10.1016/j.bbrc.2007.01.084

PubMed ID: 17182630

Title: A novel E4BP4 element drives circadian expression of mPeriod2.

PubMed ID: 17182630

DOI: 10.1093/nar/gkl868

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 29653076

Title: E4bp4 regulates carboxylesterase 2 enzymes through repression of the nuclear receptor Rev-erbalpha in mice.

PubMed ID: 29653076

DOI: 10.1016/j.bcp.2018.04.005

PubMed ID: 30555544

Title: Small heterodimer partner regulates circadian cytochromes p450 and drug-induced hepatotoxicity.

PubMed ID: 30555544

DOI: 10.7150/thno.28676

PubMed ID: 32190943

Title: PBX1 promotes development of natural killer cells by binding directly to the Nfil3 promoter.

PubMed ID: 32190943

DOI: 10.1096/fj.202000121r

Sequence Information:

  • Length: 462
  • Mass: 50943
  • Checksum: DC711EB4CAC0112E
  • Sequence:
    • MQLRKMQTIK KEPAPLDPTS SSDKMLLLNS ALAEVAEDLA SGEDLLLNEG SMGKNKSSAC 
RRKREFIPDE KKDAMYWEKR RKNNEAAKRS REKRRLNDLV LENKLIALGE ENATLKAELL 
SLKLKFGLIS STAYAQEIQK LSNSTAVYFQ DYQTSKAAVS SFVDEHEPAM VAGSCISVIK 
HSPQSSLSDV SEVSSVEHTQ ESPAQGGCRS PENKFPVIKQ EPVELESFAR EAREERGTYS 
TSIYQSYMGS SFSTYSHSPP LLQVHGSTSN SPRTSEADEG VVGKSSDGED EQQVPKGPIH 
SPVELQRVHA TVVKVPEVNP SALPHKLRIK AKAMQVKVEA LDSEFEGMQK LSSPADAIAK 
RHFDLEKHGT SGMAHSSLPP FSVQVTNIQD WSLKSEHWHH KELSSKTQSS FKTGVVEVKD 
GGYKVSEAEN LYLKQGIANL SAEVVSLKRF IATQPISASD SR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.