Genular: Defining Cellular Identity and Function

Details for: Nfkb1

Gene ID: 18033

Symbol: Nfkb1

Ensembl ID: ENSMUSG00000028163

Description: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

Associated with

Activation of nf-kappab in b cells
(R-MMU-1169091)
Adaptive immune system
(R-MMU-1280218)
C-type lectin receptors (clrs)
(R-MMU-5621481)
Cd209 (dc-sign) signaling
(R-MMU-5621575)
Chromatin modifying enzymes
(R-MMU-3247509)
Chromatin organization
(R-MMU-4839726)
Clec7a (dectin-1) signaling
(R-MMU-5607764)
Cytokine signaling in immune system
(R-MMU-1280215)
Cytosolic sensors of pathogen-associated dna
(R-MMU-1834949)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-MMU-168928)
Death receptor signaling
(R-MMU-73887)
Dex/h-box helicases activate type i ifn and inflammatory cytokines production
(R-MMU-3134963)
Downstream signaling events of b cell receptor (bcr)
(R-MMU-1168372)
Downstream tcr signaling
(R-MMU-202424)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated nf-kb activation
(R-MMU-2871837)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-1 family signaling
(R-MMU-446652)
Interleukin-1 processing
(R-MMU-448706)
Interleukin-1 signaling
(R-MMU-9020702)
Interleukin-17 signaling
(R-MMU-448424)
Map3k8 (tpl2)-dependent mapk1/3 activation
(R-MMU-5684264)
Map kinase activation
(R-MMU-450294)
Myd88 cascade initiated on plasma membrane
(R-MMU-975871)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-MMU-166058)
Neutrophil degranulation
(R-MMU-6798695)
Nf-kb is activated and signals survival
(R-MMU-209560)
P75 ntr receptor-mediated signalling
(R-MMU-193704)
P75ntr signals via nf-kb
(R-MMU-193639)
Pkmts methylate histone lysines
(R-MMU-3214841)
Regulated proteolysis of p75ntr
(R-MMU-193692)
Rip-mediated nfkb activation via zbp1
(R-MMU-1810476)
Signaling by interleukins
(R-MMU-449147)
Signaling by the b cell receptor (bcr)
(R-MMU-983705)
Tak1-dependent ikk and nf-kappa-b activation
(R-MMU-445989)
Tcr signaling
(R-MMU-202403)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Traf6 mediated nf-kb activation
(R-MMU-933542)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Zbp1(dai) mediated induction of type i ifns
(R-MMU-1606322)
Actinin binding
(GO:0042805)
Apoptotic process
(GO:0006915)
Canonical nf-kappab signal transduction
(GO:0007249)
Cellular response to stress
(GO:0033554)
Chemokine production
(GO:0032602)
Chromatin binding
(GO:0003682)
Cytokine production
(GO:0001816)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
Gene expression
(GO:0010467)
Heat shock protein binding
(GO:0031072)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Jnk cascade
(GO:0007254)
Mapk cascade
(GO:0000165)
Negative regulation of calcidiol 1-monooxygenase activity
(GO:0010956)
Negative regulation of cytokine production
(GO:0001818)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of interleukin-12 production
(GO:0032695)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Non-canonical nf-kappab signal transduction
(GO:0038061)
Positive regulation of gene expression
(GO:0010628)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein sequestering activity
(GO:0140311)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to cytokine
(GO:0034097)
Response to muscle stretch
(GO:0035994)
Response to organic cyclic compound
(GO:0014070)
Response to oxidative stress
(GO:0006979)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Signal transduction
(GO:0007165)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coregulator activity
(GO:0003712)

Other Information

Proteins

Nuclear factor NF-kappa-B p105 subunit

Genular Protein ID: 3284614899

Symbol: NFKB1_MOUSE

Name: Nuclear factor NF-kappa-B p105 subunit

UniProtKB Accession Codes:

P25799 B2RRQ6 Q3TZE8 Q3V2V6 Q6TDG8 Q75ZL1 Q80Y21 Q8C712

Database IDs:

Citations:

PubMed ID: 2203532

Title: Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal.

PubMed ID: 2203532

DOI: 10.1016/0092-8674(90)90276-k

PubMed ID: 1339305

Title: I kappa B gamma, a 70 kd protein identical to the C-terminal half of p110 NF-kappa B: a new member of the I kappa B family.

PubMed ID: 1339305

DOI: 10.1016/0092-8674(92)90082-n

PubMed ID: 8398903

Title: The activity of a 70 kilodalton I kappa B molecule identical to the carboxyl terminus of the p105 NF-kappa B precursor is modulated by protein kinase A.

PubMed ID: 8398903

PubMed ID: 7969179

Title: Alternate RNA splicing of murine nfkb1 generates a nuclear isoform of the p50 precursor NF-kappa B1 that can function as a transactivator of NF-kappa B-regulated transcription.

PubMed ID: 7969179

DOI: 10.1128/mcb.14.12.8460-8470.1994

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 8183915

Title: Alternative splicing of RNA transcripts encoded by the murine p105 NF-kappa B gene generates I kappa B gamma isoforms with different inhibitory activities.

PubMed ID: 8183915

DOI: 10.1073/pnas.91.10.4367

PubMed ID: 9529257

Title: Cotranslational biogenesis of NF-kappaB p50 by the 26S proteasome.

PubMed ID: 9529257

DOI: 10.1016/s0092-8674(00)81409-9

PubMed ID: 11356851

Title: A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei.

PubMed ID: 11356851

DOI: 10.1074/jbc.m103426200

PubMed ID: 11931770

Title: Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor.

PubMed ID: 11931770

DOI: 10.1016/s1097-2765(02)00469-0

PubMed ID: 15051764

Title: A defect in nucleosome remodeling prevents IL-12(p35) gene transcription in neonatal dendritic cells.

PubMed ID: 15051764

DOI: 10.1084/jem.20031272

PubMed ID: 15241416

Title: Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta.

PubMed ID: 15241416

DOI: 10.1038/nature02738

PubMed ID: 18270204

Title: Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation.

PubMed ID: 18270204

DOI: 10.1074/jbc.m709663200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 7530332

Title: Structure of NF-kappa B p50 homodimer bound to a kappa B site.

PubMed ID: 7530332

DOI: 10.1038/373303a0

PubMed ID: 9384558

Title: The role of DNA in the mechanism of NFkappaB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits.

PubMed ID: 9384558

DOI: 10.1016/s0969-2126(97)00293-1

PubMed ID: 9865694

Title: The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation.

PubMed ID: 9865694

DOI: 10.1016/s0092-8674(00)81699-2

PubMed ID: 9450761

Title: Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA.

PubMed ID: 9450761

DOI: 10.1038/34956

PubMed ID: 11970948

Title: The X-ray crystal structure of the NF-kappa B p50.p65 heterodimer bound to the interferon beta -kappa B site.

PubMed ID: 11970948

DOI: 10.1074/jbc.m200006200

PubMed ID: 11970949

Title: The kappa B DNA sequence from the HIV long terminal repeat functions as an allosteric regulator of HIV transcription.

PubMed ID: 11970949

DOI: 10.1074/jbc.m200007200

PubMed ID: 12886018

Title: Crystal structure of NF-kappaB (p50)2 complexed to a high-affinity RNA aptamer.

PubMed ID: 12886018

DOI: 10.1073/pnas.1632011100

PubMed ID: 17869269

Title: X-ray structure of a NF-kappaB p50/RelB/DNA complex reveals assembly of multiple dimers on tandem kappaB sites.

PubMed ID: 17869269

DOI: 10.1016/j.jmb.2007.08.039

Sequence Information:

Length: 971
Mass: 105615
Checksum: 91EA9C595E375C30
Sequence:

MADDDPYGTG QMFHLNTALT HSIFNAELYS PEIPLSTDGP YLQILEQPKQ RGFRFRYVCE 
GPSHGGLPGA SSEKNKKSYP QVKICNYVGP AKVIVQLVTN GKNIHLHAHS LVGKHCEDGV 
CTVTAGPKDM VVGFANLGIL HVTKKKVFET LEARMTEACI RGYNPGLLVH SDLAYLQAEG 
GGDRQLTDRE KEIIRQAAVQ QTKEMDLSVV RLMFTAFLPD STGSFTRRLE PVVSDAIYDS 
KAPNASNLKI VRMDRTAGCV TGGEEIYLLC DKVQKDDIQI RFYEEEENGG VWEGFGDFSP 
TDVHRQFAIV FKTPKYKDVN ITKPASVFVQ LRRKSDLETS EPKPFLYYPE IKDKEEVQRK 
RQKLMPNFSD SFGGGSGAGA GGGGMFGSGG GGGSTGSPGP GYGYSNYGFP PYGGITFHPG 
VTKSNAGVTH GTINTKFKNG PKDCAKSDDE ESLTLPEKET EGEGPSLPMA CTKTEPIALA 
STMEDKEQDM GFQDNLFLEK ALQLARRHAN ALFDYAVTGD VKMLLAVQRH LTAVQDENGD 
SVLHLAIIHL HAQLVRDLLE VTSGLISDDI INMRNDLYQT PLHLAVITKQ EDVVEDLLRV 
GADLSLLDRW GNSVLHLAAK EGHDRILSIL LKSRKAAPLI DHPNGEGLNA IHIAVMSNSL 
PCLLLLVAAG AEVNAQEQKS GRTALHLAVE YDNISLAGCL LLEGDAHVDS TTYDGTTPLH 
IAAGRGSTRL AALLKAAGAD PLVENFEPLY DLDDSWEKAG EDEGVVPGTT PLDMAANWQV 
FDILNGKPYE PVFTSDDILP QGDMKQLTED TRLQLCKLLE IPDPDKNWAT LAQKLGLGIL 
NNAFRLSPAP SKTLMDNYEV SGGTIKELME ALQQMGYTEA IEVIQAAFRT PATTASSPVT 
TAQVHCLPLS SSSTRQHIDE LRDSDSVCDS GVETSFRKLS FTESLTGDSP LLSLNKMPHG 
YGQEGPIEGK I

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nfkb1

Associated with

Other Information

Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal. PubMed ID: 2203532

I kappa B gamma, a 70 kd protein identical to the C-terminal half of p110 NF-kappa B: a new member of the I kappa B family. PubMed ID: 1339305

The activity of a 70 kilodalton I kappa B molecule identical to the carboxyl terminus of the p105 NF-kappa B precursor is modulated by protein kinase A. PubMed ID: 8398903

Alternate RNA splicing of murine nfkb1 generates a nuclear isoform of the p50 precursor NF-kappa B1 that can function as a transactivator of NF-kappa B-regulated transcription. PubMed ID: 7969179

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Alternative splicing of RNA transcripts encoded by the murine p105 NF-kappa B gene generates I kappa B gamma isoforms with different inhibitory activities. PubMed ID: 8183915

Cotranslational biogenesis of NF-kappaB p50 by the 26S proteasome. PubMed ID: 9529257

A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei. PubMed ID: 11356851

Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor. PubMed ID: 11931770

A defect in nucleosome remodeling prevents IL-12(p35) gene transcription in neonatal dendritic cells. PubMed ID: 15051764

Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta. PubMed ID: 15241416

Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation. PubMed ID: 18270204

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Structure of NF-kappa B p50 homodimer bound to a kappa B site. PubMed ID: 7530332

The role of DNA in the mechanism of NFkappaB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits. PubMed ID: 9384558

The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation. PubMed ID: 9865694

Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA. PubMed ID: 9450761

The X-ray crystal structure of the NF-kappa B p50.p65 heterodimer bound to the interferon beta -kappa B site. PubMed ID: 11970948

The kappa B DNA sequence from the HIV long terminal repeat functions as an allosteric regulator of HIV transcription. PubMed ID: 11970949

Crystal structure of NF-kappaB (p50)2 complexed to a high-affinity RNA aptamer. PubMed ID: 12886018

X-ray structure of a NF-kappaB p50/RelB/DNA complex reveals assembly of multiple dimers on tandem kappaB sites. PubMed ID: 17869269