Genular: Defining Cellular Identity and Function

Details for: Nfkbia

Gene ID: 18035

Symbol: Nfkbia

Ensembl ID: ENSMUSG00000021025

Description: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

Associated with

Activation of nf-kappab in b cells
(R-MMU-1169091)
Adaptive immune system
(R-MMU-1280218)
C-type lectin receptors (clrs)
(R-MMU-5621481)
Clec7a (dectin-1) signaling
(R-MMU-5607764)
Cytokine signaling in immune system
(R-MMU-1280215)
Cytosolic sensors of pathogen-associated dna
(R-MMU-1834949)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-MMU-168928)
Death receptor signaling
(R-MMU-73887)
Deubiquitination
(R-MMU-5688426)
Downstream signaling events of b cell receptor (bcr)
(R-MMU-1168372)
Downstream tcr signaling
(R-MMU-202424)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated nf-kb activation
(R-MMU-2871837)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-1 family signaling
(R-MMU-446652)
Interleukin-1 signaling
(R-MMU-9020702)
Metabolism of proteins
(R-MMU-392499)
Myd88 cascade initiated on plasma membrane
(R-MMU-975871)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-MMU-166058)
Nf-kb is activated and signals survival
(R-MMU-209560)
P75 ntr receptor-mediated signalling
(R-MMU-193704)
P75ntr signals via nf-kb
(R-MMU-193639)
Post-translational protein modification
(R-MMU-597592)
Rip-mediated nfkb activation via zbp1
(R-MMU-1810476)
Signaling by interleukins
(R-MMU-449147)
Signaling by the b cell receptor (bcr)
(R-MMU-983705)
Signal transduction
(R-MMU-162582)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of immune response proteins
(R-MMU-4755510)
Tak1-dependent ikk and nf-kappa-b activation
(R-MMU-445989)
Tcr signaling
(R-MMU-202403)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Traf6 mediated nf-kb activation
(R-MMU-933542)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Ub-specific processing proteases
(R-MMU-5689880)
Zbp1(dai) mediated induction of type i ifns
(R-MMU-1606322)
B cell receptor signaling pathway
(GO:0050853)
Canonical nf-kappab signal transduction
(GO:0007249)
Cellular response to biotic stimulus
(GO:0071216)
Cellular response to cytokine stimulus
(GO:0071345)
Cellular response to organic cyclic compound
(GO:0071407)
Cellular response to tumor necrosis factor
(GO:0071356)
Cytoplasmic sequestering of nf-kappab
(GO:0007253)
Enzyme binding
(GO:0019899)
Heat shock protein binding
(GO:0031072)
Identical protein binding
(GO:0042802)
Interleukin-1-mediated signaling pathway
(GO:0070498)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Molecular sequestering activity
(GO:0140313)
Negative regulation of canonical nf-kappab signal transduction
(GO:0043124)
Negative regulation of lipid storage
(GO:0010888)
Negative regulation of macrophage derived foam cell differentiation
(GO:0010745)
Negative regulation of myeloid cell differentiation
(GO:0045638)
Negative regulation of nf-kappab transcription factor activity
(GO:0032088)
Negative regulation of notch signaling pathway
(GO:0045746)
Nf-kappab binding
(GO:0051059)
Non-canonical nf-kappab signal transduction
(GO:0038061)
Notch signaling pathway
(GO:0007219)
Nuclear localization sequence binding
(GO:0008139)
Nucleotide-binding oligomerization domain containing 1 signaling pathway
(GO:0070427)
Nucleotide-binding oligomerization domain containing 2 signaling pathway
(GO:0070431)
Nucleus
(GO:0005634)
Positive regulation of cholesterol efflux
(GO:0010875)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of protein metabolic process
(GO:0051247)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription initiation by rna polymerase ii
(GO:0060261)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein import into nucleus
(GO:0006606)
Protein sequestering activity
(GO:0140311)
Regulation of cell population proliferation
(GO:0042127)
Regulation of gene expression
(GO:0010468)
Response to exogenous dsrna
(GO:0043330)
Response to lipopolysaccharide
(GO:0032496)
Response to muramyl dipeptide
(GO:0032495)
Response to muscle stretch
(GO:0035994)
Toll-like receptor 4 signaling pathway
(GO:0034142)
Transcription regulator inhibitor activity
(GO:0140416)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

NF-kappa-B inhibitor alpha

Genular Protein ID: 3532563905

Symbol: IKBA_MOUSE

Name: NF-kappa-B inhibitor alpha

UniProtKB Accession Codes:

Q9Z1E3 Q3U9W9 Q3UB40 Q80ZX5

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10199915

Title: Structural analysis, expression, and chromosomal localization of the mouse ikba gene.

PubMed ID: 10199915

DOI: 10.1007/s002510050512

PubMed ID: 7878466

Title: Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation.

PubMed ID: 7878466

DOI: 10.1126/science.7878466

PubMed ID: 9859996

Title: Identification of the receptor component of the IkappaBalpha-ubiquitin ligase.

PubMed ID: 9859996

DOI: 10.1038/25159

PubMed ID: 9990853

Title: Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP.

PubMed ID: 9990853

DOI: 10.1101/gad.13.3.284

PubMed ID: 10097128

Title: Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.

PubMed ID: 10097128

DOI: 10.1073/pnas.96.7.3859

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 314
Mass: 35071
Checksum: E1783F8E1BA93813
Sequence:

MFQPAGHGQD WAMEGPRDGL KKERLVDDRH DSGLDSMKDE EYEQMVKELR EIRLQPQEAP 
LAAEPWKQQL TEDGDSFLHL AIIHEEKPLT MEVIGQVKGD LAFLNFQNNL QQTPLHLAVI 
TNQPGIAEAL LKAGCDPELR DFRGNTPLHL ACEQGCLASV AVLTQTCTPQ HLHSVLQATN 
YNGHTCLHLA SIHGYLAIVE HLVTLGADVN AQEPCNGRTA LHLAVDLQNP DLVSLLLKCG 
ADVNRVTYQG YSPYQLTWGR PSTRIQQQLG QLTLENLQML PESEDEESYD TESEFTEDEL 
PYDDCVFGGQ RLTL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nfkbia

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structural analysis, expression, and chromosomal localization of the mouse ikba gene. PubMed ID: 10199915

Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation. PubMed ID: 7878466

Identification of the receptor component of the IkappaBalpha-ubiquitin ligase. PubMed ID: 9859996

Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP. PubMed ID: 9990853

Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1. PubMed ID: 10097128

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079