Genular: Defining Cellular Identity and Function

Details for: Ngf

Gene ID: 18049

Symbol: Ngf

Ensembl ID: ENSMUSG00000027859

Description: nerve growth factor

Associated with

Activation of trka receptors
(R-MMU-187015)
Arms-mediated activation
(R-MMU-170984)
Axonal growth stimulation
(R-MMU-209563)
Cell death signalling via nrage, nrif and nade
(R-MMU-204998)
Death receptor signaling
(R-MMU-73887)
Expression and processing of neurotrophins
(R-MMU-9036866)
Frs2-mediated activation
(R-MMU-170968)
Nade modulates death signalling
(R-MMU-205025)
Nf-kb is activated and signals survival
(R-MMU-209560)
Nfg and prongf binds to p75ntr
(R-MMU-205017)
Ngf processing
(R-MMU-167060)
Nrif signals cell death from the nucleus
(R-MMU-205043)
P75 ntr receptor-mediated signalling
(R-MMU-193704)
P75ntr recruits signalling complexes
(R-MMU-209543)
P75ntr regulates axonogenesis
(R-MMU-193697)
P75ntr signals via nf-kb
(R-MMU-193639)
Pi3k/akt activation
(R-MMU-198203)
Prolonged erk activation events
(R-MMU-169893)
Retrograde neurotrophin signalling
(R-MMU-177504)
Signaling by ntrk1 (trka)
(R-MMU-187037)
Signaling by ntrks
(R-MMU-166520)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signalling to erks
(R-MMU-187687)
Signal transduction
(R-MMU-162582)
Trka activation by ngf
(R-MMU-187042)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Adult locomotory behavior
(GO:0008344)
Axon
(GO:0030424)
Axon extension
(GO:0048675)
Cellular response to acid chemical
(GO:0071229)
Circadian rhythm
(GO:0007623)
Cysteine-type endopeptidase activator activity involved in apoptotic process
(GO:0008656)
Death receptor agonist activity
(GO:0038177)
Endoplasmic reticulum lumen
(GO:0005788)
Endosome
(GO:0005768)
Enzyme inhibitor activity
(GO:0004857)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Extrinsic apoptotic signaling pathway via death domain receptors
(GO:0008625)
Growth factor activity
(GO:0008083)
Lipid binding
(GO:0008289)
Memory
(GO:0007613)
Metalloendopeptidase inhibitor activity
(GO:0008191)
Modulation of chemical synaptic transmission
(GO:0050804)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of peptidase activity
(GO:0010466)
Negative regulation of type b pancreatic cell apoptotic process
(GO:2000675)
Nerve development
(GO:0021675)
Nerve growth factor receptor binding
(GO:0005163)
Nerve growth factor signaling pathway
(GO:0038180)
Neuron apoptotic process
(GO:0051402)
Neuron projection development
(GO:0031175)
Neuron projection morphogenesis
(GO:0048812)
Peptidase inhibitor activity
(GO:0030414)
Peripheral nervous system development
(GO:0007422)
Positive regulation of axon extension
(GO:0045773)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of collateral sprouting
(GO:0048672)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of dna binding
(GO:0043388)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of neuron maturation
(GO:0014042)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of neurotrophin trk receptor signaling pathway
(GO:0051388)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of protein autophosphorylation
(GO:0031954)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of protein ubiquitination
(GO:0031398)
Positive regulation of ras protein signal transduction
(GO:0046579)
Positive regulation of stem cell proliferation
(GO:2000648)
Protein phosphorylation
(GO:0006468)
Regulation of neuron differentiation
(GO:0045664)
Regulation of neurotransmitter secretion
(GO:0046928)
Regulation of release of sequestered calcium ion into cytosol
(GO:0051279)
Sensory perception of pain
(GO:0019233)
Signaling receptor binding
(GO:0005102)
Synaptic vesicle
(GO:0008021)
Transmembrane receptor protein tyrosine kinase activator activity
(GO:0030297)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)

Other Information

Proteins

Beta-nerve growth factor
Q6LDU8_MOUSE

Genular Protein ID: 1251415473

Symbol: NGF_MOUSE

Name: Beta-nerve growth factor

UniProtKB Accession Codes:

P01139 Q63864 Q6LDB7

Database IDs:

Citations:

PubMed ID: 6336309

Title: Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor.

PubMed ID: 6336309

DOI: 10.1038/302538a0

PubMed ID: 6688123

Title: Human beta-nerve growth factor gene sequence highly homologous to that of mouse.

PubMed ID: 6688123

DOI: 10.1038/303821a0

PubMed ID: 6327169

Title: Sequence homology of human and mouse beta-NGF subunit genes.

PubMed ID: 6327169

DOI: 10.1101/sqb.1983.048.01.048

PubMed ID: 3670305

Title: Mouse nerve growth factor gene: structure and expression.

PubMed ID: 3670305

DOI: 10.1128/mcb.7.9.3057-3064.1987

PubMed ID: 1284621

Title: Production and secretion of nerve growth factor by clonal striated muscle cell line, G8-1.

PubMed ID: 1284621

DOI: 10.1016/0197-0186(92)90155-k

PubMed ID: 4566923

Title: Amino acid sequences of mouse 2.5S nerve growth factor. II. Isolation and characterization of the thermolytic and peptic peptides and the complete covalent structure.

PubMed ID: 4566923

DOI: 10.1021/bi00725a018

PubMed ID: 22155786

Title: Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac.

PubMed ID: 22155786

DOI: 10.1126/scisignal.2002060

PubMed ID: 23785138

Title: p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks.

PubMed ID: 23785138

DOI: 10.1523/jneurosci.2757-12.2013

PubMed ID: 24908487

Title: SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia.

PubMed ID: 24908487

DOI: 10.1016/j.neuron.2014.04.022

PubMed ID: 1956407

Title: New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor.

PubMed ID: 1956407

DOI: 10.1038/354411a0

PubMed ID: 8201620

Title: Nerve growth factor in different crystal forms displays structural flexibility and reveals zinc binding sites.

PubMed ID: 8201620

DOI: 10.1006/jmbi.1994.1380

PubMed ID: 9351801

Title: Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins.

PubMed ID: 9351801

DOI: 10.1016/s0969-2126(97)00280-3

PubMed ID: 20036257

Title: Molecular and structural insight into proNGF engagement of p75NTR and sortilin.

PubMed ID: 20036257

DOI: 10.1016/j.jmb.2009.12.030

PubMed ID: 22649032

Title: Structural and functional insights into lipid-bound nerve growth factors.

PubMed ID: 22649032

DOI: 10.1096/fj.12-207316

PubMed ID: 26144237

Title: The structure of nerve growth factor in complex with lysophosphatidylinositol.

PubMed ID: 26144237

DOI: 10.1107/s2053230x15008870

PubMed ID: 30061605

Title: Structural insights into SorCS2-Nerve Growth Factor complex formation.

PubMed ID: 30061605

DOI: 10.1038/s41467-018-05405-z

Sequence Information:

Length: 241
Mass: 27077
Checksum: 164465E1DC550081
Sequence:

MSMLFYTLIT AFLIGVQAEP YTDSNVPEGD SVPEAHWTKL QHSLDTALRR ARSAPTAPIA 
ARVTGQTRNI TVDPRLFKKR RLHSPRVLFS TQPPPTSSDT LDLDFQAHGT IPFNRTHRSK 
RSSTHPVFHM GEFSVCDSVS VWVGDKTTAT DIKGKEVTVL AEVNINNSVF RQYFFETKCR 
ASNPVESGCR GIDSKHWNSY CTTTHTFVKA LTTDEKQAAW RFIRIDTACV CVLSRKATRR 
G

Genular Protein ID: 4094838251

Symbol: Q6LDU8_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q6LDU8

Database IDs:

Citations:

PubMed ID: 3670305

Title: Mouse nerve growth factor gene: structure and expression.

PubMed ID: 3670305

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 307
Mass: 33787
Checksum: EF067B28BE81E0B2
Sequence:

MLCLKPVKLG SLEVGHGQHG GVLACGRAVQ GAGWHAGPKL TSVSGPNKGF AKDAAFYTGR 
SEVHSVMSML FYTLITAFLI GVQAEPYTDS NVPEGDSVPE AHWTKLQHSL DTALRRARSA 
PTAPIAARVT GQTRNITVDP RLFKKRRLHS PRVLFSTQPP PTSSDTLDLD FQAHGTIPFN 
RTHRSKRSST HPVFHMGEFS VCDSVSVWVG DKTTATDIKG KEVTVLAEVN INNSVFRQYF 
FETKCRASNP VESGCRGIDS KHWNSYCTTT HTFVKALTTD EKQAAWRFIR IDTACVCVLS 
RKATRRG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ngf

Associated with

Other Information

Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor. PubMed ID: 6336309

Human beta-nerve growth factor gene sequence highly homologous to that of mouse. PubMed ID: 6688123

Sequence homology of human and mouse beta-NGF subunit genes. PubMed ID: 6327169

Mouse nerve growth factor gene: structure and expression. PubMed ID: 3670305

Production and secretion of nerve growth factor by clonal striated muscle cell line, G8-1. PubMed ID: 1284621

Amino acid sequences of mouse 2.5S nerve growth factor. II. Isolation and characterization of the thermolytic and peptic peptides and the complete covalent structure. PubMed ID: 4566923

Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac. PubMed ID: 22155786

p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. PubMed ID: 23785138

SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia. PubMed ID: 24908487

New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor. PubMed ID: 1956407

Nerve growth factor in different crystal forms displays structural flexibility and reveals zinc binding sites. PubMed ID: 8201620

Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins. PubMed ID: 9351801

Molecular and structural insight into proNGF engagement of p75NTR and sortilin. PubMed ID: 20036257

Structural and functional insights into lipid-bound nerve growth factors. PubMed ID: 22649032

The structure of nerve growth factor in complex with lysophosphatidylinositol. PubMed ID: 26144237

Structural insights into SorCS2-Nerve Growth Factor complex formation. PubMed ID: 30061605

Mouse nerve growth factor gene: structure and expression. PubMed ID: 3670305

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Database document:

PubMed ID: 6336309

PubMed ID: 6688123

PubMed ID: 6327169

PubMed ID: 3670305

PubMed ID: 1284621

PubMed ID: 4566923

PubMed ID: 22155786

PubMed ID: 23785138

PubMed ID: 24908487

PubMed ID: 1956407

PubMed ID: 8201620

PubMed ID: 9351801

PubMed ID: 20036257

PubMed ID: 22649032

PubMed ID: 26144237

PubMed ID: 30061605

PubMed ID: 3670305

PubMed ID: 10349636

PubMed ID: 11042159

PubMed ID: 11076861

PubMed ID: 11217851

PubMed ID: 12466851

PubMed ID: 16141073

PubMed ID: 19468303