Genular: Defining Cellular Identity and Function

Details for: Ngfr

Gene ID: 18053

Symbol: Ngfr

Ensembl ID: ENSMUSG00000000120

Description: nerve growth factor receptor (TNFR superfamily, member 16)

Associated with

Axonal growth inhibition (rhoa activation)
(R-MMU-193634)
Axonal growth stimulation
(R-MMU-209563)
Cell death signalling via nrage, nrif and nade
(R-MMU-204998)
Death receptor signaling
(R-MMU-73887)
Nade modulates death signalling
(R-MMU-205025)
Nf-kb is activated and signals survival
(R-MMU-209560)
Nfg and prongf binds to p75ntr
(R-MMU-205017)
Nrif signals cell death from the nucleus
(R-MMU-205043)
P75 ntr receptor-mediated signalling
(R-MMU-193704)
P75ntr recruits signalling complexes
(R-MMU-209543)
P75ntr regulates axonogenesis
(R-MMU-193697)
P75ntr signals via nf-kb
(R-MMU-193639)
Regulated proteolysis of p75ntr
(R-MMU-193692)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Amyloid-beta binding
(GO:0001540)
Apoptotic process
(GO:0006915)
Axon guidance
(GO:0007411)
Calmodulin binding
(GO:0005516)
Cell-cell junction
(GO:0005911)
Cell differentiation
(GO:0030154)
Cell surface
(GO:0009986)
Cellular response to amyloid-beta
(GO:1904646)
Cellular response to oxidative stress
(GO:0034599)
Central nervous system development
(GO:0007417)
Circadian regulation of gene expression
(GO:0032922)
Circadian rhythm
(GO:0007623)
Coreceptor activity
(GO:0015026)
Cytoplasm
(GO:0005737)
Death receptor activity
(GO:0005035)
Dendrite membrane
(GO:0032590)
Detection of temperature stimulus
(GO:0016048)
Dorsal aorta development
(GO:0035907)
External side of plasma membrane
(GO:0009897)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Fibroblast proliferation
(GO:0048144)
Glucose homeostasis
(GO:0042593)
Hair follicle development
(GO:0001942)
Hair follicle morphogenesis
(GO:0031069)
Identical protein binding
(GO:0042802)
Intracellular glucose homeostasis
(GO:0001678)
Intracellular protein transport
(GO:0006886)
Membrane
(GO:0016020)
Multicellular organism development
(GO:0007275)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
(GO:1903588)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of dendritic spine development
(GO:0061000)
Negative regulation of fibroblast growth factor receptor signaling pathway
(GO:0040037)
Negative regulation of hair follicle development
(GO:0051799)
Negative regulation of mitochondrial depolarization
(GO:0051902)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of neuron projection development
(GO:0010977)
Nerve development
(GO:0021675)
Nerve growth factor binding
(GO:0048406)
Nervous system development
(GO:0007399)
Neuromuscular junction
(GO:0031594)
Neuronal cell body membrane
(GO:0032809)
Neuron apoptotic process
(GO:0051402)
Neurotrophin binding
(GO:0043121)
Neurotrophin trka receptor binding
(GO:0005168)
Nuclear envelope
(GO:0005635)
Nucleoplasm
(GO:0005654)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of apoptotic signaling pathway
(GO:2001235)
Positive regulation of excitatory postsynaptic potential
(GO:2000463)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of mirna transcription
(GO:1902895)
Positive regulation of myelination
(GO:0031643)
Positive regulation of neural precursor cell proliferation
(GO:2000179)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of odontogenesis of dentin-containing tooth
(GO:0042488)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein localization to nucleus
(GO:1900182)
Positive regulation of rho protein signal transduction
(GO:0035025)
Positive regulation of synaptic transmission, cholinergic
(GO:0032224)
Positive regulation of synaptic transmission, glutamatergic
(GO:0051968)
Postsynaptic density
(GO:0014069)
Preprotein binding
(GO:0070678)
Presynaptic modulation of chemical synaptic transmission
(GO:0099171)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Regulation of gene expression
(GO:0010468)
Regulation of reactive oxygen species metabolic process
(GO:2000377)
Rho protein signal transduction
(GO:0007266)
Rhythmic process
(GO:0048511)
Signal transduction
(GO:0007165)
Skin development
(GO:0043588)
Small gtpase binding
(GO:0031267)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Tumor necrosis factor receptor superfamily member 16

Genular Protein ID: 1217907193

Symbol: TNR16_MOUSE

Name: Tumor necrosis factor receptor superfamily member 16

UniProtKB Accession Codes:

Q9Z0W1 Q8CFT3

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9857182

Title: Low-affinity nerve-growth factor receptor (p75NTR) can serve as a receptor for rabies virus.

PubMed ID: 9857182

DOI: 10.1093/emboj/17.24.7250

PubMed ID: 1317267

Title: Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system.

PubMed ID: 1317267

DOI: 10.1016/0092-8674(92)90286-l

PubMed ID: 11559852

Title: Complete ablation of the neurotrophin receptor p75NTR causes defects both in the nervous and the vascular system.

PubMed ID: 11559852

DOI: 10.1038/nn730

PubMed ID: 11830582

Title: Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis.

PubMed ID: 11830582

DOI: 10.1074/jbc.m106342200

PubMed ID: 22155786

Title: Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac.

PubMed ID: 22155786

DOI: 10.1126/scisignal.2002060

PubMed ID: 22923615

Title: Olfactomedin 1 interacts with the Nogo A receptor complex to regulate axon growth.

PubMed ID: 22923615

DOI: 10.1074/jbc.m112.389916

PubMed ID: 22460790

Title: p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity.

PubMed ID: 22460790

DOI: 10.1073/pnas.1103638109

PubMed ID: 23785138

Title: p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks.

PubMed ID: 23785138

DOI: 10.1523/jneurosci.2757-12.2013

PubMed ID: 24908487

Title: SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia.

PubMed ID: 24908487

DOI: 10.1016/j.neuron.2014.04.022

PubMed ID: 27457814

Title: SorCS2 is required for BDNF-dependent plasticity in the hippocampus.

PubMed ID: 27457814

DOI: 10.1038/mp.2016.108

PubMed ID: 29909994

Title: The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior.

PubMed ID: 29909994

DOI: 10.1016/j.neuron.2018.05.024

Sequence Information:

Length: 427
Mass: 45647
Checksum: 7AC73263F7B31436
Sequence:

MRRAGAACSA MDRLRLLLLL LLLLGVSFGG AKETCSTGMY THSGECCKAC NLGEGVAQPC 
GANQTVCEPC LDSVTFSDVV SATEPCKPCT ECLGLQSMSA PCVEADDAVC RCSYGYYQDE 
ETGRCEACSV CGVGSGLVFS CQDKQNTVCE ECPEGTYSDE ANHVDPCLPC TVCEDTERQL 
RECTPWADAE CEEIPGRWIT RSTPPEGSDV TTPSTQEPEA PPERDLIAST VADTVTTVMG 
SSQPVVTRGT ADNLIPVYCS ILAAVVVGLV AYIAFKRWNS CKQNKQGANS RPVNQTPPPE 
GEKLHSDSGI SVDSQSLHDQ QTHTQTASGQ ALKGDGNLYS SLPLTKREEV EKLLNGDTWR 
HLAGELGYQP EHIDSFTHEA CPVRALLASW GAQDSATLDA LLAALRRIQR ADIVESLCSE 
STATSPV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ngfr

Associated with

Other Information

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Low-affinity nerve-growth factor receptor (p75NTR) can serve as a receptor for rabies virus. PubMed ID: 9857182

Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. PubMed ID: 1317267

Complete ablation of the neurotrophin receptor p75NTR causes defects both in the nervous and the vascular system. PubMed ID: 11559852

Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis. PubMed ID: 11830582

Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac. PubMed ID: 22155786

Olfactomedin 1 interacts with the Nogo A receptor complex to regulate axon growth. PubMed ID: 22923615

p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. PubMed ID: 22460790

p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. PubMed ID: 23785138

SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia. PubMed ID: 24908487

SorCS2 is required for BDNF-dependent plasticity in the hippocampus. PubMed ID: 27457814

The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior. PubMed ID: 29909994