Details for: Nhlh2

Gene ID: 18072

Symbol: Nhlh2

Ensembl ID: ENSMUSG00000048540

Description: nescient helix loop helix 2

Associated with

  • Apoptotic process
    (GO:0006915)
  • Cell differentiation
    (GO:0030154)
  • Cell migration in hindbrain
    (GO:0021535)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Hypothalamus gonadotrophin-releasing hormone neuron development
    (GO:0021888)
  • Male gonad development
    (GO:0008584)
  • Male mating behavior
    (GO:0060179)
  • Multicellular organism development
    (GO:0007275)
  • Nucleus
    (GO:0005634)
  • Ovulation cycle
    (GO:0042698)
  • Peripheral nervous system development
    (GO:0007422)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Other Information

Genular Protein ID: 1854395088

Symbol: HEN2_MOUSE

Name: Helix-loop-helix protein 2

UniProtKB Accession Codes:

Q64221 Q8BFV7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 12 Ensembl 3 GO 18 Gene3D 1 GeneTree 1 Genevisible 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 1633105

Title: NSCL-2: a basic domain helix-loop-helix gene expressed in early neurogenesis.

PubMed ID: 1633105

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9011755

Title: Transient expression of the basic helix-loop-helix protein NSCL-2 in the mouse cerebellum during postnatal development.

PubMed ID: 9011755

DOI: 10.1016/0169-328x(95)00282-w

PubMed ID: 9090387

Title: Hypogonadism and obesity in mice with a targeted deletion of the Nhlh2 gene.

PubMed ID: 9090387

DOI: 10.1038/ng0497-397

PubMed ID: 12419415

Title: Reduced voluntary activity precedes adult-onset obesity in Nhlh2 knockout mice.

PubMed ID: 12419415

DOI: 10.1016/s0031-9384(02)00885-5

PubMed ID: 15470499

Title: NSCL-1 and NSCL-2 synergistically determine the fate of GnRH-1 neurons and control necdin gene expression.

PubMed ID: 15470499

DOI: 10.1038/sj.emboj.7600431

PubMed ID: 15465527

Title: The Nhlh2 transcription factor is required for female sexual behavior and reproductive longevity.

PubMed ID: 15465527

DOI: 10.1016/j.yhbeh.2004.03.006

PubMed ID: 17573818

Title: NSCL-1 and -2 control the formation of precerebellar nuclei by orchestrating the migration of neuronal precursor cells.

PubMed ID: 17573818

DOI: 10.1111/j.1471-4159.2007.04694.x

PubMed ID: 17717072

Title: Pubertal impairment in Nhlh2 null mice is associated with hypothalamic and pituitary deficiencies.

PubMed ID: 17717072

DOI: 10.1210/me.2005-0337

PubMed ID: 18356286

Title: Nescient helix-loop-helix 2 interacts with signal transducer and activator of transcription 3 to regulate transcription of prohormone convertase 1/3.

PubMed ID: 18356286

DOI: 10.1210/me.2008-0010

PubMed ID: 19436734

Title: Defective peripheral nerve development is linked to abnormal architecture and metabolic activity of adipose tissue in Nscl-2 mutant mice.

PubMed ID: 19436734

DOI: 10.1371/journal.pone.0005516

PubMed ID: 20808804

Title: Deletion of Nhlh2 results in a defective torpor response and reduced Beta adrenergic receptor expression in adipose tissue.

PubMed ID: 20808804

DOI: 10.1371/journal.pone.0012324

PubMed ID: 21664420

Title: Melanocortin 4 receptor is a transcriptional target of nescient helix-loop-helix-2.

PubMed ID: 21664420

DOI: 10.1016/j.mce.2011.05.022

PubMed ID: 23785158

Title: Loss of NSCL-2 in gonadotropin releasing hormone neurons leads to reduction of pro-opiomelanocortin neurons in specific hypothalamic nuclei and causes visceral obesity.

PubMed ID: 23785158

DOI: 10.1523/jneurosci.5287-12.2013

Sequence Information:

  • Length: 135
  • Mass: 15004
  • Checksum: E7872BF22A601405
  • Sequence:
    • MMLSPDQAAD SDHPSSTHSD PESLGGADTK VLGSVSDLEP VEEADGDGKG GSRAALYPHP 
QQLSREEKRR RRRATAKYRS AHATRERIRV EAFNLAFAEL RKLLPTLPPD KKLSKIEILR 
LAICYISYLN HVLDV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.