Genular: Defining Cellular Identity and Function

Details for: Nid1

Gene ID: 18073

Symbol: Nid1

Ensembl ID: ENSMUSG00000005397

Description: nidogen 1

Associated with

Degradation of the extracellular matrix
(R-MMU-1474228)
Laminin interactions
(R-MMU-3000157)
Basement membrane
(GO:0005604)
Calcium ion binding
(GO:0005509)
Canonical wnt signaling pathway
(GO:0060070)
Cell-matrix adhesion
(GO:0007160)
Cell adhesion
(GO:0007155)
Cell periphery
(GO:0071944)
Collagen-containing extracellular matrix
(GO:0062023)
Collagen binding
(GO:0005518)
Extracellular matrix
(GO:0031012)
Extracellular matrix binding
(GO:0050840)
Extracellular matrix organization
(GO:0030198)
Extracellular matrix structural constituent
(GO:0005201)
Extracellular region
(GO:0005576)
Glomerular basement membrane development
(GO:0032836)
Laminin-1 binding
(GO:0043237)
Laminin binding
(GO:0043236)
Positive regulation of cell-substrate adhesion
(GO:0010811)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of integrin-mediated signaling pathway
(GO:2001046)
Positive regulation of muscle cell differentiation
(GO:0051149)
Protein binding
(GO:0005515)
Protein complex involved in cell-matrix adhesion
(GO:0098637)
Proteoglycan binding
(GO:0043394)
Regulation of basement membrane organization
(GO:0110011)
Wnt-protein binding
(GO:0017147)
Wnt receptor activity
(GO:0042813)

Other Information

Proteins

Nidogen-1

Genular Protein ID: 3316691691

Symbol: NID1_MOUSE

Name: Nidogen-1

UniProtKB Accession Codes:

P10493 Q3TKX9 Q8BQI3 Q8C3U8 Q8C9P6

Database IDs:

Citations:

PubMed ID: 3264556

Title: Amino acid sequence and domain structure of entactin. Homology with epidermal growth factor precursor and low density lipoprotein receptor.

PubMed ID: 3264556

DOI: 10.1083/jcb.107.6.2749

PubMed ID: 2496973

Title: Amino acid sequence of mouse nidogen, a multidomain basement membrane protein with binding activity for laminin, collagen IV and cells.

PubMed ID: 2496973

DOI: 10.1002/j.1460-2075.1989.tb03349.x

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8224873

Title: Characterization of the 5' end of the mouse Ent gene encoding the basement membrane protein, entactin.

PubMed ID: 8224873

DOI: 10.1016/0378-1119(93)90205-h

PubMed ID: 7601446

Title: Exon organization of the mouse entactin gene corresponds to the structural domains of the polypeptide and has regional homology to the low-density lipoprotein receptor gene.

PubMed ID: 7601446

DOI: 10.1016/0888-7543(95)80204-y

PubMed ID: 3084254

Title: Purification and structural characterization of intact and fragmented nidogen obtained from a tumor basement membrane.

PubMed ID: 3084254

DOI: 10.1111/j.1432-1033.1986.tb09605.x

PubMed ID: 8326911

Title: Structure and localization of O- and N-linked oligosaccharide chains on basement membrane protein nidogen.

PubMed ID: 8326911

DOI: 10.1016/s0934-8832(11)80005-3

PubMed ID: 9299350

Title: Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules.

PubMed ID: 9299350

DOI: 10.1006/jmbi.1997.1244

PubMed ID: 9501082

Title: Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin.

PubMed ID: 9501082

DOI: 10.1093/emboj/17.6.1606

PubMed ID: 11589703

Title: Recombinant domains of mouse nidogen-1 and their binding to basement membrane proteins and monoclonal antibodies.

PubMed ID: 11589703

DOI: 10.1046/j.0014-2956.2001.02437.x

PubMed ID: 16574105

Title: Identification of the basement membrane protein nidogen as a candidate ligand for tumor endothelial marker 7 in vitro and in vivo.

PubMed ID: 16574105

DOI: 10.1016/j.febslet.2006.03.033

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 36792666

Title: SVEP1 is an endogenous ligand for the orphan receptor PEAR1.

PubMed ID: 36792666

DOI: 10.1038/s41467-023-36486-0

PubMed ID: 11427896

Title: Crystal structure and mutational analysis of a perlecan-binding fragment of nidogen-1.

PubMed ID: 11427896

DOI: 10.1038/89683

Sequence Information:

Length: 1245
Mass: 136538
Checksum: 92D12D128E6EF144
Sequence:

MLDASGCSWA MWTWALLQLL LLVGPGGCLN RQELFPFGPG QGDLELEAGD DVVSPSLELI 
GELSFYDRTD ITSVYVTTNG IIAMSEPPAT EYHPGTFPPS FGSVAPFLAD LDTTDGLGNV 
YYREDLSPFI IQMAAEYVQR GFPEVSFQPT SVVVVTWESV APYGGPSSSP AEEGKRNTFQ 
AVLASSNSSS YAIFLYPEDG LQFFTTFSKK DESQVPAVVG FSKGLVGFLW KSNGAYNIFA 
NDRESIENLA KSSNAGHQGV WVFEIGSPAT AKGVVSADVN LDLDDDGADY EDEDYDLVTS 
HLGLEDVATP SPSHSPRRGY PDPHNVPRIL SPGYEATERP RGVPTERTRS FQLPAERFPQ 
HHPQVIDVDE VEETGVVFSY NTGSQQTCAN NRHQCSVHAE CRDYATGFCC RCVANYTGNG 
RQCVAEGSPQ RVNGKVKGRI FVGSSQVPVV FENTDLHSYV VMNHGRSYTA ISTIPETVGY 
SLLPLAPIGG IIGWMFAVEQ DGFKNGFSIT GGEFTRQAEV TFLGHPGKLV LKQQFSGIDE 
HGHLTISTEL EGRVPQIPYG ASVHIEPYTE LYHYSSSVIT SSSTREYTVM EPDQDGAAPS 
HTHIYQWRQT ITFQECAHDD ARPALPSTQQ LSVDSVFVLY NKEERILRYA LSNSIGPVRD 
GSPDALQNPC YIGTHGCDSN AACRPGPGTQ FTCECSIGFR GDGQTCYDID ECSEQPSRCG 
NHAVCNNLPG TFRCECVEGY HFSDRGTCVA AEDQRPINYC ETGLHNCDIP QRAQCIYMGG 
SSYTCSCLPG FSGDGRACRD VDECQHSRCH PDAFCYNTPG SFTCQCKPGY QGDGFRCMPG 
EVSKTRCQLE REHILGAAGG ADAQRPTLQG MFVPQCDEYG HYVPTQCHHS TGYCWCVDRD 
GRELEGSRTP PGMRPPCLST VAPPIHQGPV VPTAVIPLPP GTHLLFAQTG KIERLPLERN 
TMKKTEAKAF LHIPAKVIIG LAFDCVDKVV YWTDISEPSI GRASLHGGEP TTIIRQDLGS 
PEGIALDHLG RTIFWTDSQL DRIEVAKMDG TQRRVLFDTG LVNPRGIVTD PVRGNLYWTD 
WNRDNPKIET SHMDGTNRRI LAQDNLGLPN GLTFDAFSSQ LCWVDAGTHR AECLNPAQPG 
RRKVLEGLQY PFAVTSYGKN LYYTDWKTNS VIAMDLAISK EMDTFHPHKQ TRLYGITIAL 
SQCPQGHNYC SVNNGGCTHL CLPTPGSRTC RCPDNTLGVD CIERK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nid1

Associated with

Other Information

Amino acid sequence and domain structure of entactin. Homology with epidermal growth factor precursor and low density lipoprotein receptor. PubMed ID: 3264556

Amino acid sequence of mouse nidogen, a multidomain basement membrane protein with binding activity for laminin, collagen IV and cells. PubMed ID: 2496973

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the 5' end of the mouse Ent gene encoding the basement membrane protein, entactin. PubMed ID: 8224873

Exon organization of the mouse entactin gene corresponds to the structural domains of the polypeptide and has regional homology to the low-density lipoprotein receptor gene. PubMed ID: 7601446

Purification and structural characterization of intact and fragmented nidogen obtained from a tumor basement membrane. PubMed ID: 3084254

Structure and localization of O- and N-linked oligosaccharide chains on basement membrane protein nidogen. PubMed ID: 8326911

Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules. PubMed ID: 9299350

Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin. PubMed ID: 9501082

Recombinant domains of mouse nidogen-1 and their binding to basement membrane proteins and monoclonal antibodies. PubMed ID: 11589703

Identification of the basement membrane protein nidogen as a candidate ligand for tumor endothelial marker 7 in vitro and in vivo. PubMed ID: 16574105

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SVEP1 is an endogenous ligand for the orphan receptor PEAR1. PubMed ID: 36792666

Crystal structure and mutational analysis of a perlecan-binding fragment of nidogen-1. PubMed ID: 11427896