Details for: Ninj1

Gene ID: 18081

Symbol: Ninj1

Ensembl ID: ENSMUSG00000037966

Description: ninjurin 1

Associated with

Other Information

Genular Protein ID: 3798297280

Symbol: NINJ1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9465296

Title: The human homologue of the ninjurin gene maps to the candidate region of hereditary sensory neuropathy type I (HSNI).

PubMed ID: 9465296

DOI: 10.1006/geno.1997.5084

PubMed ID: 19557008

Title: Ninjurin1 mediates macrophage-induced programmed cell death during early ocular development.

PubMed ID: 19557008

DOI: 10.1038/cdd.2009.78

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23142597

Title: The N-terminal ectodomain of Ninjurin1 liberated by MMP9 has chemotactic activity.

PubMed ID: 23142597

DOI: 10.1016/j.bbrc.2012.10.099

PubMed ID: 23690620

Title: Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality.

PubMed ID: 23690620

DOI: 10.1073/pnas.1221242110

PubMed ID: 24347169

Title: Ninjurin1 deficiency attenuates susceptibility of experimental autoimmune encephalomyelitis in mice.

PubMed ID: 24347169

DOI: 10.1074/jbc.m113.498212

PubMed ID: 24917672

Title: Ninjurin1 enhances the basal motility and transendothelial migration of immune cells by inducing protrusive membrane dynamics.

PubMed ID: 24917672

DOI: 10.1074/jbc.m113.532358

PubMed ID: 24979788

Title: Inhibition of Ninjurin 1 restores erectile function through dual angiogenic and neurotrophic effects in the diabetic mouse.

PubMed ID: 24979788

DOI: 10.1073/pnas.1403471111

PubMed ID: 25860173

Title: Contribution of Ninjurin1 to Toll-like receptor 4 signaling and systemic inflammation.

PubMed ID: 25860173

DOI: 10.1165/rcmb.2014-0354oc

PubMed ID: 25766274

Title: Ninjurin1 is a novel factor to regulate angiogenesis through the function of pericytes.

PubMed ID: 25766274

DOI: 10.1253/circj.cj-14-1376

PubMed ID: 26677008

Title: Ninjurin1 regulates lipopolysaccharide-induced inflammation through direct binding.

PubMed ID: 26677008

DOI: 10.3892/ijo.2015.3296

PubMed ID: 28067406

Title: Ninjurin1 assembles into a homomeric protein complex maintained by N-linked glycosylation.

PubMed ID: 28067406

DOI: 10.1002/jcb.25872

PubMed ID: 27815839

Title: Disruption of Ninjurin1 leads to repetitive and anxiety-like behaviors in mice.

PubMed ID: 27815839

DOI: 10.1007/s12035-016-0207-6

PubMed ID: 29073078

Title: Ninjurin 1 has two opposing functions in tumorigenesis in a p53-dependent manner.

PubMed ID: 29073078

DOI: 10.1073/pnas.1711814114

PubMed ID: 30354207

Title: Pericyte-specific ninjurin1 deletion attenuates vessel maturation and blood flow recovery in hind limb ischemia.

PubMed ID: 30354207

DOI: 10.1161/atvbaha.118.311375

PubMed ID: 30510259

Title: Ninjurin1 plays a crucial role in pulmonary fibrosis by promoting interaction between macrophages and alveolar epithelial cells.

PubMed ID: 30510259

DOI: 10.1038/s41598-018-35997-x

PubMed ID: 31526566

Title: Ninjurin 1 mediates peripheral nerve regeneration through Schwann cell maturation of NG2-positive cells.

PubMed ID: 31526566

DOI: 10.1016/j.bbrc.2019.09.007

PubMed ID: 30700695

Title: Ninjurin1 positively regulates osteoclast development by enhancing the survival of prefusion osteoclasts.

PubMed ID: 30700695

DOI: 10.1038/s12276-018-0201-3

PubMed ID: 31091274

Title: Ninjurin1 regulates striated muscle growth and differentiation.

PubMed ID: 31091274

DOI: 10.1371/journal.pone.0216987

PubMed ID: 32883094

Title: Anti-inflammatory actions of soluble ninjurin-1 ameliorate atherosclerosis.

PubMed ID: 32883094

DOI: 10.1161/circulationaha.120.046907

PubMed ID: 33472215

Title: NINJ1 mediates plasma membrane rupture during lytic cell death.

PubMed ID: 33472215

DOI: 10.1038/s41586-021-03218-7

PubMed ID: 36468682

Title: Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death.

PubMed ID: 36468682

DOI: 10.7554/elife.78609

PubMed ID: 37196676

Title: Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury.

PubMed ID: 37196676

DOI: 10.1038/s41586-023-06191-5

PubMed ID: 37198476

Title: Structural basis of NINJ1-mediated plasma membrane rupture in cell death.

PubMed ID: 37198476

DOI: 10.1038/s41586-023-05991-z

Sequence Information:

  • Length: 152
  • Mass: 16555
  • Checksum: E261CB447BC0A2E6
  • Sequence:
  • MESGTEEYEL NGDLRPGSPG SPDALPPRWG LRNRPINVNH YANKKSAAES MLDIALLMAN 
    ASQLKAVVEQ GNDFAFFVPL VVLISISLVL QIGVGVLLIF LVKYDLNNPA KHAKLDFLNN 
    LATGLVFIIV VVNIFITAFG VQKPVMDVAP RQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.