Details for: Nkx2 2

Gene ID: 18088

Symbol: Nkx2 2

Ensembl ID: ENSMUSG00000027434

Description: NK2 homeobox 2

Associated with

  • Astrocyte differentiation
    (GO:0048708)
  • Cell development
    (GO:0048468)
  • Cell differentiation
    (GO:0030154)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Digestive tract development
    (GO:0048565)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Endocrine pancreas development
    (GO:0031018)
  • Intracellular anatomical structure
    (GO:0005622)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of neuron differentiation
    (GO:0045665)
  • Nervous system development
    (GO:0007399)
  • Neuroendocrine cell differentiation
    (GO:0061101)
  • Neuron differentiation
    (GO:0030182)
  • Neuron fate specification
    (GO:0048665)
  • Nucleus
    (GO:0005634)
  • Oligodendrocyte development
    (GO:0014003)
  • Oligodendrocyte differentiation
    (GO:0048709)
  • Pancreatic a cell fate commitment
    (GO:0003326)
  • Pancreatic pp cell fate commitment
    (GO:0003329)
  • Positive regulation of epithelial cell differentiation
    (GO:0030858)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of neuron differentiation
    (GO:0045666)
  • Positive regulation of oligodendrocyte differentiation
    (GO:0048714)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Smoothened signaling pathway
    (GO:0007224)
  • Spinal cord motor neuron differentiation
    (GO:0021522)
  • Spinal cord oligodendrocyte cell differentiation
    (GO:0021529)
  • Spinal cord oligodendrocyte cell fate specification
    (GO:0021530)
  • Transcription factor binding
    (GO:0008134)
  • Type b pancreatic cell development
    (GO:0003323)
  • Type b pancreatic cell differentiation
    (GO:0003309)
  • Type b pancreatic cell fate commitment
    (GO:0003327)
  • Ventral spinal cord interneuron fate determination
    (GO:0060580)

Other Information

Genular Protein ID: 89827866

Symbol: NKX22_MOUSE

Name: Homeobox protein Nkx-2.2

UniProtKB Accession Codes:

P42586

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 39 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 5 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 7939711

Title: The embryonic vertebrate forebrain: the prosomeric model.

PubMed ID: 7939711

DOI: 10.1126/science.7939711

PubMed ID: 8654958

Title: The cDNA sequence of murine Nkx-2.2.

PubMed ID: 8654958

DOI: 10.1016/0378-1119(95)00745-8

PubMed ID: 1346742

Title: Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain.

PubMed ID: 1346742

DOI: 10.1016/0896-6273(92)90291-k

PubMed ID: 11076772

Title: Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas.

PubMed ID: 11076772

DOI: 10.1242/dev.127.24.5533

PubMed ID: 14573534

Title: Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex.

PubMed ID: 14573534

DOI: 10.1523/jneurosci.23-29-09547.2003

PubMed ID: 19759004

Title: Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3.

PubMed ID: 19759004

DOI: 10.1074/jbc.m109.048694

Sequence Information:

  • Length: 273
  • Mass: 30126
  • Checksum: 1F3DBB8127667F19
  • Sequence:
    • MSLTNTKTGF SVKDILDLPD TNDEDGSVAE GPEEESEGPE PAKRAGPLGQ GALDAVQSLP 
LKSPFYDSSD NPYTRWLAST EGLQYSLHGL AASAPPQDSS SKSPEPSADE SPDNDKETQG 
GGGDAGKKRK RRVLFSKAQT YELERRFRQQ RYLSAPEREH LASLIRLTPT QVKIWFQNHR 
YKMKRARAEK GMEVTPLPSP RRVAVPVLVR DGKPCHALKA QDLAAATFQA GIPFSAYSAQ 
SLQHMQYNAQ YSSASTPQYP TAHPLVQAQQ WTW

Genular Protein ID: 4190427563

Symbol: Q8BRS9_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8BRS9

Database IDs:

AGR 1 ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 InterPro 4 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 248
  • Mass: 27798
  • Checksum: 00F062658AD0702D
  • Sequence:
    • MSLTNTKTGF SVKDILDLPD TNDEDGSVAE GPEEESEGPE PAKRAGPLGQ GALDAVQSLP 
LKSPFYDSSD NPYTRWLAST EGLQYSLHGL AASAPPQDSS SKSPEPSADE SPDNDKETQG 
GGGDAGKKRK RRVLFSKAQT YELERRFRQQ RYLSAPEREH LASLIRLTPT QVKIWFQNHR 
YKMKRARAEK AFQNRRMDAR IEAAVPIVSA RWSDWIRKQF QVGRLTQAWE HNLVICGFEG 
CLGKVHLQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.