Genular: Defining Cellular Identity and Function

Details for: Nkx2 5

Gene ID: 18091

Symbol: Nkx2 5

Ensembl ID: ENSMUSG00000015579

Description: NK2 homeobox 5

Associated with

Adult heart development
(GO:0007512)
Apoptotic process
(GO:0006915)
Apoptotic process involved in heart morphogenesis
(GO:0003278)
Atrial cardiac muscle cell development
(GO:0055014)
Atrial cardiac muscle tissue development
(GO:0003228)
Atrioventricular node development
(GO:0003162)
Bundle of his development
(GO:0003166)
Cardiac conduction system development
(GO:0003161)
Cardiac muscle cell development
(GO:0055013)
Cardiac muscle cell differentiation
(GO:0055007)
Cardiac muscle cell proliferation
(GO:0060038)
Cardiac muscle tissue development
(GO:0048738)
Cardiac muscle tissue morphogenesis
(GO:0055008)
Cardiac ventricle formation
(GO:0003211)
Cardiac ventricle morphogenesis
(GO:0003208)
Cell differentiation
(GO:0030154)
Cell population proliferation
(GO:0008283)
Chromatin binding
(GO:0003682)
Dna-binding transcription activator activity
(GO:0001216)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Embryonic heart tube development
(GO:0035050)
Endoderm development
(GO:0007492)
Epithelial cell differentiation
(GO:0030855)
Epithelial cell proliferation
(GO:0050673)
Heart development
(GO:0007507)
Heart looping
(GO:0001947)
Heart morphogenesis
(GO:0003007)
Hemopoiesis
(GO:0030097)
Histone deacetylase binding
(GO:0042826)
Identical protein binding
(GO:0042802)
Multicellular organism development
(GO:0007275)
Negative regulation of cardiac muscle cell apoptotic process
(GO:0010667)
Negative regulation of myotube differentiation
(GO:0010832)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Outflow tract morphogenesis
(GO:0003151)
Outflow tract septum morphogenesis
(GO:0003148)
Pharyngeal system development
(GO:0060037)
Positive regulation of cardioblast differentiation
(GO:0051891)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of heart contraction
(GO:0045823)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of sodium ion transport
(GO:0010765)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Proepicardium development
(GO:0003342)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Pulmonary myocardium development
(GO:0003350)
Purkinje myocyte differentiation
(GO:0003168)
Regulation of cardiac muscle cell proliferation
(GO:0060043)
Regulation of cardiac muscle contraction
(GO:0055117)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Right ventricular cardiac muscle tissue morphogenesis
(GO:0003221)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Septum secundum development
(GO:0003285)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Spleen development
(GO:0048536)
Thyroid gland development
(GO:0030878)
Tongue development
(GO:0043586)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Vasculogenesis
(GO:0001570)
Ventricular cardiac muscle cell development
(GO:0055015)
Ventricular cardiac myofibril assembly
(GO:0055005)
Ventricular trabecula myocardium morphogenesis
(GO:0003222)

Other Information

Proteins

Homeobox protein Nkx-2.5

Genular Protein ID: 3078639222

Symbol: NKX25_MOUSE

Name: Homeobox protein Nkx-2.5

UniProtKB Accession Codes:

P42582 P97335

Database IDs:

Citations:

PubMed ID: 7904557

Title: Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants.

PubMed ID: 7904557

DOI: 10.1242/dev.119.2.419

PubMed ID: 7910553

Title:

PubMed ID: 7910553

DOI: 10.1242/dev.119.3.969

PubMed ID: 9778505

Title: A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice.

PubMed ID: 9778505

DOI: 10.1242/dev.125.22.4461

PubMed ID: 7690144

Title: Csx: a murine homeobox-containing gene specifically expressed in the developing heart.

PubMed ID: 7690144

DOI: 10.1073/pnas.90.17.8145

PubMed ID: 9748262

Title: Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors.

PubMed ID: 9748262

DOI: 10.1074/jbc.273.40.25875

PubMed ID: 9584153

Title: The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression.

PubMed ID: 9584153

DOI: 10.1128/mcb.18.6.3120

PubMed ID: 12023302

Title: Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation.

PubMed ID: 12023302

DOI: 10.1101/gad.222902

PubMed ID: 14757752

Title: A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5.

PubMed ID: 14757752

DOI: 10.1083/jcb.200309159

PubMed ID: 15542826

Title: Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors.

PubMed ID: 15542826

DOI: 10.1128/mcb.24.23.10151-10160.2004

PubMed ID: 16556915

Title: Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field.

PubMed ID: 16556915

DOI: 10.1242/dev.02309

PubMed ID: 17584735

Title: Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors.

PubMed ID: 17584735

DOI: 10.1074/jbc.m703724200

PubMed ID: 19483677

Title: A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome.

PubMed ID: 19483677

DOI: 10.1038/nature08086

PubMed ID: 22560297

Title: Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module.

PubMed ID: 22560297

DOI: 10.1016/j.devcel.2012.02.009

Sequence Information:

Length: 318
Mass: 34163
Checksum: 6A3E7859F46D4FA6
Sequence:

MFPSPALTPT PFSVKDILNL EQQQRSLASG DLSARLEATL APASCMLAAF KPEAYSGPEA 
AASGLAELRA EMGPAPSPPK CSPAFPAAPT FYPGAYGDPD PAKDPRADKK ELCALQKAVE 
LDKAETDGAE RPRARRRRKP RVLFSQAQVY ELERRFKQQR YLSAPERDQL ASVLKLTSTQ 
VKIWFQNRRY KCKRQRQDQT LELLGPPPPP ARRIAVPVLV RDGKPCLGDP AAYAPAYGVG 
LNAYGYNAYP YPSYGGAACS PGYSCAAYPA APPAAQPPAA SANSNFVNFG VGDLNTVQSP 
GMPQGNSGVS TLHGIRAW

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nkx2 5

Associated with

Other Information

Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. PubMed ID: 7904557

PubMed ID: 7910553

A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice. PubMed ID: 9778505

Csx: a murine homeobox-containing gene specifically expressed in the developing heart. PubMed ID: 7690144

Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. PubMed ID: 9748262

The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression. PubMed ID: 9584153

Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation. PubMed ID: 12023302

A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5. PubMed ID: 14757752

Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors. PubMed ID: 15542826

Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field. PubMed ID: 16556915

Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors. PubMed ID: 17584735

A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome. PubMed ID: 19483677

Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module. PubMed ID: 22560297