Genular: Defining Cellular Identity and Function

Details for: Nkx2 6

Gene ID: 18092

Symbol: Nkx2 6

Ensembl ID: ENSMUSG00000044186

Description: NK2 homeobox 6

Associated with

Apoptotic process
(GO:0006915)
Atrial cardiac muscle cell development
(GO:0055014)
Cell differentiation
(GO:0030154)
Cell population proliferation
(GO:0008283)
Digestive tract development
(GO:0048565)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Embryonic heart tube development
(GO:0035050)
Epithelial cell apoptotic process
(GO:1904019)
Epithelial cell differentiation
(GO:0030855)
Epithelial cell proliferation
(GO:0050673)
Heart development
(GO:0007507)
Hypothalamus development
(GO:0021854)
Multicellular organism development
(GO:0007275)
Negative regulation of epithelial cell apoptotic process
(GO:1904036)
Nucleus
(GO:0005634)
Pericardium development
(GO:0060039)
Pharyngeal system development
(GO:0060037)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Tongue development
(GO:0043586)
Ventricular cardiac muscle cell development
(GO:0055015)

Other Information

Proteins

Homeobox protein Nkx-2.6
Q9CVN3_MOUSE

Genular Protein ID: 2300594829

Symbol: NKX26_MOUSE

Name: Homeobox protein Nkx-2.6

UniProtKB Accession Codes:

P43688

Database IDs:

Citations:

PubMed ID: 9545560

Title: Expression of NK-2 class homeobox gene Nkx2-6 in foregut endoderm and heart.

PubMed ID: 9545560

DOI: 10.1016/s0925-4773(98)00037-9

PubMed ID: 7904557

Title: Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants.

PubMed ID: 7904557

DOI: 10.1242/dev.119.2.419

PubMed ID: 9486544

Title: Nkx2.6 expression is transiently and specifically restricted to the branchial region of pharyngeal-stage mouse embryos.

PubMed ID: 9486544

DOI: 10.1016/s0925-4773(97)00174-3

PubMed ID: 10733590

Title: Phenotypic characterization of the murine Nkx2.6 homeobox gene by gene targeting.

PubMed ID: 10733590

DOI: 10.1128/mcb.20.8.2874-2879.2000

PubMed ID: 11390666

Title: Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynx.

PubMed ID: 11390666

DOI: 10.1128/mcb.21.13.4391-4398.2001

Sequence Information:

Length: 289
Mass: 31597
Checksum: DBF8740A39CC0805
Sequence:

MLSSPVASTP FSVADILRLE CQQKDSKTLS QWELHRNPVK PRYLRMNQES GWFESSDRAQ 
AVPFRCTWET VLEMGSNPVG EPQTPPGTIS RLGARNPMTD RGVGNLSGDM RRGGPVSTRT 
RPQRKSRVLF SQAQVLALER RFKQQRYLTA PEREHLASAL QLTSTQVKIW FQNRRYKSKS 
QRQDQTLELA GHPLAPRRVA VPVLVLDGKP CLDPDVAAFL GPYKATSPYS CFGGYAGTPY 
DASYASRCTS ASAGPGPLTP LASSGFSPGG QSAAPQGHLP ATPQGVTAW

Genular Protein ID: 3158520001

Symbol: Q9CVN3_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9CVN3

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 216
Mass: 23101
Checksum: 1B644838E010DF60
Sequence:

MGSNPVGEPQ TPPGTISRLG ARNPMTDRGV GNLSGDMRRG GPVSTRTRPQ RKSRVLFSQA 
QVLALERRFK QQRYLTAPER EHLASALQLT STQVKIWFQN RRYKSKSQRQ DQTLELAGHP 
LAPRRVAVPV LVLDGKPCLD PDVAAFLGPY KATSPYSCFG GYAGTPYDAS YASRCTSASA 
GPGPLTPLAS SGFSPGGQSA APQGHLPATP QGVTAW

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nkx2 6

Associated with

Other Information

Expression of NK-2 class homeobox gene Nkx2-6 in foregut endoderm and heart. PubMed ID: 9545560

Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. PubMed ID: 7904557

Nkx2.6 expression is transiently and specifically restricted to the branchial region of pharyngeal-stage mouse embryos. PubMed ID: 9486544

Phenotypic characterization of the murine Nkx2.6 homeobox gene by gene targeting. PubMed ID: 10733590

Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynx. PubMed ID: 11390666

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073