Details for: Nkx3 1

Gene ID: 18095

Symbol: Nkx3 1

Ensembl ID: ENSMUSG00000022061

Description: NK3 homeobox 1

Associated with

  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Androgen receptor signaling pathway
    (GO:0030521)
  • Branching involved in prostate gland morphogenesis
    (GO:0060442)
  • Branching morphogenesis of an epithelial tube
    (GO:0048754)
  • Cell differentiation
    (GO:0030154)
  • Cellular response to hypoxia
    (GO:0071456)
  • Cellular response to steroid hormone stimulus
    (GO:0071383)
  • Cysteine-type endopeptidase activator activity involved in apoptotic process
    (GO:0008656)
  • Cytosol
    (GO:0005829)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription factor binding
    (GO:0140297)
  • Dna binding
    (GO:0003677)
  • Dna damage response
    (GO:0006974)
  • Dorsal aorta development
    (GO:0035907)
  • Epithelial cell proliferation
    (GO:0050673)
  • Epithelial cell proliferation involved in prostate gland development
    (GO:0060767)
  • Epithelial cell proliferation involved in salivary gland morphogenesis
    (GO:0060664)
  • Heart development
    (GO:0007507)
  • Histone deacetylase binding
    (GO:0042826)
  • Internal genitalia morphogenesis
    (GO:0035260)
  • Mads box domain binding
    (GO:0097162)
  • Male gonad development
    (GO:0008584)
  • Metanephros development
    (GO:0001656)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of epithelial cell proliferation
    (GO:0050680)
  • Negative regulation of epithelial cell proliferation involved in prostate gland development
    (GO:0060770)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of insulin-like growth factor receptor signaling pathway
    (GO:0043569)
  • Nuclear estrogen receptor binding
    (GO:0030331)
  • Nuclear receptor activity
    (GO:0004879)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Pharyngeal system development
    (GO:0060037)
  • Phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0043491)
  • Positive regulation of androgen secretion
    (GO:2000836)
  • Positive regulation of apoptotic signaling pathway
    (GO:2001235)
  • Positive regulation of cell division
    (GO:0051781)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043280)
  • Positive regulation of dna-binding transcription factor activity
    (GO:0051091)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of intrinsic apoptotic signaling pathway
    (GO:2001244)
  • Positive regulation of mitotic cell cycle
    (GO:0045931)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Prostate gland development
    (GO:0030850)
  • Protein binding
    (GO:0005515)
  • Protein self-association
    (GO:0043621)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of protein localization
    (GO:0032880)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to testosterone
    (GO:0033574)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Salivary gland development
    (GO:0007431)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Site of dna damage
    (GO:0090734)
  • Somitogenesis
    (GO:0001756)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription factor binding
    (GO:0008134)
  • Transcription regulator inhibitor activity
    (GO:0140416)
  • Urogenital system development
    (GO:0001655)

Other Information

Genular Protein ID: 1172983101

Symbol: NKX31_MOUSE

Name: N/A

UniProtKB Accession Codes:

P97436 O09087

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 66 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 4 KEGG 1 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8943214

Title: Prostate-specific and androgen-dependent expression of a novel homeobox gene.

PubMed ID: 8943214

DOI: 10.1074/jbc.271.50.31779

PubMed ID: 9142502

Title: Tissue-specific expression of murine Nkx3.1 in the male urogenital system.

PubMed ID: 9142502

DOI: 10.1002/(sici)1097-0177(199705)209:1<127::aid-aja12>3.0.co;2-z

PubMed ID: 10215624

Title: Roles for Nkx3.1 in prostate development and cancer.

PubMed ID: 10215624

DOI: 10.1101/gad.13.8.966

PubMed ID: 10415359

Title: Expression of the Nkx3.1 homobox gene during pre and postnatal development.

PubMed ID: 10415359

DOI: 10.1016/s0925-4773(99)00084-2

PubMed ID: 10906459

Title: Targeted disruption of the Nkx3.1 gene in mice results in morphogenetic defects of minor salivary glands: parallels to glandular duct morphogenesis in prostate.

PubMed ID: 10906459

DOI: 10.1016/s0925-4773(00)00355-5

PubMed ID: 12036903

Title: Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis.

PubMed ID: 12036903

PubMed ID: 16814806

Title: Physical and functional interactions between the prostate suppressor homeoprotein NKX3.1 and serum response factor.

PubMed ID: 16814806

DOI: 10.1016/j.jmb.2006.05.064

PubMed ID: 18816836

Title: Mouse Fem1b interacts with the Nkx3.1 homeoprotein and is required for proper male secondary sexual development.

PubMed ID: 18816836

DOI: 10.1002/dvdy.21694

Sequence Information:

  • Length: 237
  • Mass: 26824
  • Checksum: 4B074387F3BA1223
  • Sequence:
    • MLRVAEPREP RVEAGGRSPW AAPPTQSKRL TSFLIQDILR DRAERHGGHS GNPQHSPDPR 
RDSAPEPDKA GGRGVAPEDP PSIRHSPAET PTEPESDAHF ETYLLDCEHN PGDLASAPQV 
TKQPQKRSRA AFSHTQVIEL ERKFSHQKYL SAPERAHLAK NLKLTETQVK IWFQNRRYKT 
KRKQLSEDLG VLEKNSPLSL PALKDDSLPS TSLVSVYTSY PYYPYLYCLG SWHPSFW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.