Details for: Nkx6 1

Gene ID: 18096

Symbol: Nkx6 1

Ensembl ID: ENSMUSG00000035187

Description: NK6 homeobox 1

Associated with

  • Cell differentiation
    (GO:0030154)
  • Central nervous system neuron differentiation
    (GO:0021953)
  • Chromatin binding
    (GO:0003682)
  • Cytosol
    (GO:0005829)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Endocrine pancreas development
    (GO:0031018)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of oligodendrocyte differentiation
    (GO:0048715)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neurogenesis
    (GO:0022008)
  • Neuron differentiation
    (GO:0030182)
  • Nucleus
    (GO:0005634)
  • Oligodendrocyte differentiation
    (GO:0048709)
  • Pancreatic a cell differentiation
    (GO:0003310)
  • Positive regulation of insulin secretion
    (GO:0032024)
  • Positive regulation of neuron differentiation
    (GO:0045666)
  • Positive regulation of oligodendrocyte differentiation
    (GO:0048714)
  • Regulation of axon extension
    (GO:0030516)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of neuron migration
    (GO:2001222)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Smoothened signaling pathway
    (GO:0007224)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Type b pancreatic cell differentiation
    (GO:0003309)
  • Type b pancreatic cell proliferation
    (GO:0044342)

Other Information

Genular Protein ID: 1972691111

Symbol: NKX61_MOUSE

Name: Homeobox protein Nkx-6.1

UniProtKB Accession Codes:

Q99MA9 B2RQP4 Q9ERQ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 4 Ensembl 1 GO 32 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 5 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10938085

Title: Transcriptional and translational regulation of beta-cell differentiation factor Nkx6.1.

PubMed ID: 10938085

DOI: 10.1074/jbc.m004981200

PubMed ID: 11076772

Title: Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas.

PubMed ID: 11076772

DOI: 10.1242/dev.127.24.5533

PubMed ID: 10830170

Title: A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube.

PubMed ID: 10830170

DOI: 10.1016/s0092-8674(00)80853-3

Sequence Information:

  • Length: 365
  • Mass: 37705
  • Checksum: B6AABAF5748A99E8
  • Sequence:
    • MLAVGAMEGP RQSAFLLSSP PLAALHSMAE MKTPLYPAAY PPLPTGPPSS SSSSSSSSSP 
SPPLGSHNPG GLKPPAAGGL SSLGSPPQQL SAATPHGIND ILSRPSMPVA SGAALPSASP 
SGSSSSSSSS ASATSASAAA AAAAAAAAAA ASSPAGLLAG LPRFSSLSPP PPPPGLYFSP 
SAAAVAAVGR YPKPLAELPG RTPIFWPGVM QSPPWRDARL ACTPHQGSIL LDKDGKRKHT 
RPTFSGQQIF ALEKTFEQTK YLAGPERARL AYSLGMTESQ VKVWFQNRRT KWRKKHAAEM 
ATAKKKQDSE TERLKGTSEN EEDDDDYNKP LDPNSDDEKI TQLLKKHKSS GGSLLLHASE 
AEGSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.