Details for: AGRP

Gene ID: 181

Symbol: AGRP

Ensembl ID: ENSG00000159723

Description: agouti related neuropeptide

Associated with

Other Information

Genular Protein ID: 3087704506

Symbol: AGRP_HUMAN

Name: Agouti-related protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9119224

Title: Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.

PubMed ID: 9119224

DOI: 10.1101/gad.11.5.593

PubMed ID: 9311920

Title: Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein.

PubMed ID: 9311920

DOI: 10.1126/science.278.5335.135

PubMed ID: 11602360

Title: The gene structure and minimal promoter of the human agouti related protein.

PubMed ID: 11602360

DOI: 10.1016/s0378-1119(01)00705-3

PubMed ID: 11326303

Title: Association between an agouti-related protein gene polymorphism and anorexia nervosa.

PubMed ID: 11326303

DOI: 10.1038/sj.mp.4000854

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9724530

Title: Determination of disulfide structure in agouti-related protein (AGRP) by stepwise reduction and alkylation.

PubMed ID: 9724530

DOI: 10.1021/bi981082v

PubMed ID: 9892020

Title: Characterization of Agouti-related protein binding to melanocortin receptors.

PubMed ID: 9892020

DOI: 10.1210/mend.13.1.0223

PubMed ID: 11145747

Title: AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor.

PubMed ID: 11145747

DOI: 10.1210/mend.15.1.0578

PubMed ID: 17185225

Title: Structural and molecular evolutionary analysis of Agouti and Agouti-related proteins.

PubMed ID: 17185225

DOI: 10.1016/j.chembiol.2006.10.006

PubMed ID: 16384863

Title: Agouti-related protein is posttranslationally cleaved by proprotein convertase 1 to generate agouti-related protein (AGRP)83-132: interaction between AGRP83-132 and melanocortin receptors cannot be influenced by syndecan-3.

PubMed ID: 16384863

DOI: 10.1210/en.2005-1373

PubMed ID: 17041250

Title: The natural inverse agonist agouti-related protein induces arrestin-mediated endocytosis of melanocortin-3 and -4 receptors.

PubMed ID: 17041250

DOI: 10.1074/jbc.m605982200

PubMed ID: 10371151

Title: NMR structure of a minimized human agouti related protein prepared by total chemical synthesis.

PubMed ID: 10371151

DOI: 10.1016/s0014-5793(99)00553-0

PubMed ID: 11747427

Title: High-resolution NMR structure of the chemically-synthesized melanocortin receptor binding domain AGRP(87-132) of the agouti-related protein.

PubMed ID: 11747427

DOI: 10.1021/bi0117192

PubMed ID: 12056887

Title: Design, pharmacology, and NMR structure of a minimized cystine knot with agouti-related protein activity.

PubMed ID: 12056887

DOI: 10.1021/bi012000x

PubMed ID: 12213871

Title: A polymorphism in the human agouti-related protein is associated with late-onset obesity.

PubMed ID: 12213871

DOI: 10.1210/jc.2002-011834

PubMed ID: 15927146

Title: Functional analysis of the Ala67Thr polymorphism in agouti related protein associated with anorexia nervosa and leanness.

PubMed ID: 15927146

DOI: 10.1016/j.bcp.2005.04.033

Sequence Information:

  • Length: 132
  • Mass: 14440
  • Checksum: 1CCBE112C3EB10F5
  • Sequence:
  • MLTAAVLSCA LLLALPATRG AQMGLAPMEG IRRPDQALLP ELPGLGLRAP LKKTTAEQAE 
    EDLLQEAQAL AEVLDLQDRE PRSSRRCVRL HESCLGQQVP CCDPCATCYC RFFNAFCYCR 
    KLGTAMNPCS RT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.