Details for: Cd244a
Associated with
Other Information
Genular Protein ID: 3372719484
Symbol: CD244_MOUSE
Name: Natural killer cell receptor 2B4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8228228
Title: Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells.
PubMed ID: 8228228
PubMed ID: 10941850
Title: Polymorphism in the 2B4 gene of inbred mouse strains.
PubMed ID: 10941850
PubMed ID: 16141072
Title: The transcriptional landscape of the mammalian genome.
PubMed ID: 16141072
PubMed ID: 8326140
Title: A novel function-associated molecule related to non-MHC-restricted cytotoxicity mediated by activated natural killer cells and T cells.
PubMed ID: 8326140
PubMed ID: 9841922
Title: 2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48.
PubMed ID: 9841922
PubMed ID: 11739483
Title: Regulation of CD8(+) T cell proliferation by 2B4/CD48 interactions.
PubMed ID: 11739483
PubMed ID: 12734329
Title: The NK cell receptor 2B4 augments antigen-specific T cell cytotoxicity through CD48 ligation on neighboring T cells.
PubMed ID: 12734329
PubMed ID: 15169881
Title: Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors.
PubMed ID: 15169881
PubMed ID: 15998796
Title: Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn.
PubMed ID: 15998796
DOI: 10.1084/jem.20050449
PubMed ID: 16127454
Title: Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor.
PubMed ID: 16127454
DOI: 10.1038/ni1242
PubMed ID: 15905190
Title: Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions.
PubMed ID: 15905190
PubMed ID: 16425036
Title: Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters.
PubMed ID: 16425036
PubMed ID: 19648922
Title: Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells.
PubMed ID: 19648922
DOI: 10.1038/ni.1763
PubMed ID: 20962259
Title: The adapters EAT-2A and -2B are positive regulators of CD244- and CD84-dependent NK cell functions in the C57BL/6 mouse.
PubMed ID: 20962259
PubMed ID: 22683124
Title: The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells.
PubMed ID: 22683124
PubMed ID: 25643613
Title: CD244 is expressed on dendritic cells and regulates their functions.
PubMed ID: 25643613
DOI: 10.1038/icb.2014.124
PubMed ID: 15850375
Title: NMR structure of the natural killer cell receptor 2B4 (CD244): implications for ligand recognition.
PubMed ID: 15850375
DOI: 10.1021/bi050139s
PubMed ID: 17950006
Title: Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family.
PubMed ID: 17950006
Sequence Information:
- Length: 397
- Mass: 44836
- Checksum: 0E2F0D946F7B63A7
- Sequence:
MLGQAVLFTT FLLLRAHQGQ DCPDSSEEVV GVSGKPVQLR PSNIQTKDVS VQWKKTEQGS HRKIEILNWY NDGPSWSNVS FSDIYGFDYG DFALSIKSAK LQDSGHYLLE ITNTGGKVCN KNFQLLILDH VETPNLKAQW KPWTNGTCQL FLSCLVTKDD NVSYALYRGS TLISNQRNST HWENQIDASS LHTYTCNVSN RASWANHTLN FTHGCQSVPS NFRFLPFGVI IVILVTLFLG AIICFCVWTK KRKQLQFSPK EPLTIYEYVK DSRASRDQQG CSRASGSPSA VQEDGRGQRE LDRRVSEVLE QLPQQTFPGD RGTMYSMIQC KPSDSTSQEK CTVYSVVQPS RKSGSKKRNQ NSSLSCTVYE EVGNPWLKAH NPARLSRREL ENFDVYS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.