Details for: Mycn

Gene ID: 18109

Symbol: Mycn

Ensembl ID: ENSMUSG00000037169

Description: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived

Associated with

  • Astrocyte differentiation
    (GO:0048708)
  • Autosome genomic imprinting
    (GO:0141068)
  • Branching morphogenesis of an epithelial tube
    (GO:0048754)
  • Cartilage condensation
    (GO:0001502)
  • Cell population proliferation
    (GO:0008283)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Embryonic digit morphogenesis
    (GO:0042733)
  • Embryonic skeletal system morphogenesis
    (GO:0048704)
  • Epithelial cell proliferation
    (GO:0050673)
  • Kinase binding
    (GO:0019900)
  • Lung development
    (GO:0030324)
  • Negative regulation of astrocyte differentiation
    (GO:0048712)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of reactive oxygen species metabolic process
    (GO:2000378)
  • Nucleolus
    (GO:0005730)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of epithelial cell proliferation
    (GO:0050679)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of mesenchymal cell proliferation
    (GO:0002053)
  • Positive regulation of programmed cell death
    (GO:0043068)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of inner ear auditory receptor cell differentiation
    (GO:0045607)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Other Information

Genular Protein ID: 662436033

Symbol: MYCN_MOUSE

Name: N-myc proto-oncogene protein

UniProtKB Accession Codes:

P03966 Q61978

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 29 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 3513190

Title: Structure and expression of the murine N-myc gene.

PubMed ID: 3513190

DOI: 10.1073/pnas.83.6.1827

PubMed ID: 3015591

Title: Nucleotide sequence of the coding region of the mouse N-myc gene.

PubMed ID: 3015591

DOI: 10.1002/j.1460-2075.1986.tb04349.x

PubMed ID: 2555695

Title: Insertional activation of N-myc by endogenous Moloney-like murine retrovirus sequences in macrophage cell lines derived from myeloma cell line-macrophage hybrids.

PubMed ID: 2555695

DOI: 10.1128/mcb.9.10.4515-4522.1989

PubMed ID: 3287334

Title: Complete nucleotide sequence and exon-intron boundaries of the 5' non-coding region of the mouse N-myc gene.

PubMed ID: 3287334

DOI: 10.1093/nar/16.8.3589

PubMed ID: 8521822

Title: Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.

PubMed ID: 8521822

DOI: 10.1002/j.1460-2075.1995.tb00252.x

PubMed ID: 8617250

Title:

PubMed ID: 8617250

DOI: 10.1002/j.1460-2075.1996.tb00555.x

Sequence Information:

  • Length: 462
  • Mass: 49572
  • Checksum: E7AFD3DCBCABF290
  • Sequence:
    • MPSCTASTMP GMICKNPDLE FDSLQPCFYP DEDDFYFGGP DSTPPGEDIW KKFELLPTPP 
LSPSRAFPEH SPEPSNWATE MLLPEADLWG NPAEEDAFGL GGLGGLTPNP VILQDCMWSG 
FSAREKLERA VNEKLQHGHG PPGVSSACSA PGVGASSPGG RALGGSSSAS HTGATLPTDL 
SHPAAECVDP AVVFPFPVNK RESASVPAAP TSAPATSAAV TSVSVPATAP VAAPARAGGR 
PASSGEAKAL STSGEDTLSD SDDEDDEEED EEEEIDVVTV EKRRSSSNNK AVTTFTITVR 
PKTSALGLGR AQPGELILKR CVPIHQQHNY AAPSPYVESE DAPPQKKIKS EASPRPLKSV 
VPAKAKSLSP RNSDSEDSER RRNHNILERQ RRNDLRSSFL TLRDHVPELV KNEKAAKVVI 
LKKATEYVHA LQANEHQLLL EKEKLQARQQ QLLKKIEHAR TC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.