Genular: Defining Cellular Identity and Function

Details for: Nodal

Gene ID: 18119

Symbol: Nodal

Ensembl ID: ENSMUSG00000037171

Description: nodal growth differentiation factor

Associated with

Anatomical structure formation involved in morphogenesis
(GO:0048646)
Anterior/posterior axis specification
(GO:0009948)
Anterior/posterior pattern specification
(GO:0009952)
Axial mesodermal cell fate specification
(GO:0048327)
Brain development
(GO:0007420)
Cell differentiation
(GO:0030154)
Cell fate commitment
(GO:0045165)
Cell migration
(GO:0016477)
Cell migration involved in gastrulation
(GO:0042074)
Cell population proliferation
(GO:0008283)
Cytokine activity
(GO:0005125)
Determination of left/right asymmetry in lateral mesoderm
(GO:0003140)
Determination of left/right symmetry
(GO:0007368)
Digestive system development
(GO:0055123)
Digestive tract morphogenesis
(GO:0048546)
Embryonic cranial skeleton morphogenesis
(GO:0048701)
Embryonic heart tube development
(GO:0035050)
Embryonic pattern specification
(GO:0009880)
Embryonic placenta development
(GO:0001892)
Embryonic process involved in female pregnancy
(GO:0060136)
Endodermal cell differentiation
(GO:0035987)
Endoderm development
(GO:0007492)
Epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification
(GO:0060802)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Floor plate morphogenesis
(GO:0033505)
Formation of anatomical boundary
(GO:0048859)
Gastrulation
(GO:0007369)
Gastrulation with mouth forming second
(GO:0001702)
Germ cell development
(GO:0007281)
Growth factor activity
(GO:0008083)
Heart development
(GO:0007507)
Heart looping
(GO:0001947)
Inhibition of neuroepithelial cell differentiation
(GO:0002085)
In utero embryonic development
(GO:0001701)
Left lung morphogenesis
(GO:0060460)
Liver development
(GO:0001889)
Lung development
(GO:0030324)
Maternal placenta development
(GO:0001893)
Maternal process involved in parturition
(GO:0060137)
Mesendoderm development
(GO:0048382)
Mesoderm formation
(GO:0001707)
Multicellular organism development
(GO:0007275)
Negative regulation of androgen receptor signaling pathway
(GO:0060766)
Negative regulation of cell development
(GO:0010721)
Negative regulation of cell differentiation
(GO:0045596)
Negative regulation of chorionic trophoblast cell proliferation
(GO:1901383)
Negative regulation of reproductive process
(GO:2000242)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of trophoblast cell migration
(GO:1901164)
Nervous system development
(GO:0007399)
Neural fold formation
(GO:0001842)
Nodal signaling pathway
(GO:0038092)
Placenta development
(GO:0001890)
Polarity specification of proximal/distal axis
(GO:0010085)
Positive regulation of activin receptor signaling pathway
(GO:0032927)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of cell-cell adhesion
(GO:0022409)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043280)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of smad protein signal transduction
(GO:0060391)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of vascular endothelial growth factor production
(GO:0010575)
Primitive streak formation
(GO:0090009)
Protein binding
(GO:0005515)
Receptor ligand activity
(GO:0048018)
Regulation of gastrulation
(GO:0010470)
Regulation of signal transduction
(GO:0009966)
Somatic stem cell population maintenance
(GO:0035019)
Stem cell population maintenance
(GO:0019827)
Tissue morphogenesis
(GO:0048729)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Trophectodermal cell differentiation
(GO:0001829)
Trophectodermal cellular morphogenesis
(GO:0001831)
Type i activin receptor binding
(GO:0070698)
Vasculature development
(GO:0001944)

Other Information

Proteins

Nodal

Genular Protein ID: 3001808912

Symbol: NODAL_MOUSE

Name: Nodal

UniProtKB Accession Codes:

P43021 Q8BH87

Database IDs:

Citations:

PubMed ID: 8429908

Title: Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation.

PubMed ID: 8429908

DOI: 10.1038/361543a0

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 8582278

Title: Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation.

PubMed ID: 8582278

DOI: 10.1242/dev.121.11.3651

Sequence Information:

Length: 354
Mass: 40476
Checksum: 40ECFC6785BB5826
Sequence:

MSAHSLRILL LQACWALLHP RAPTAAALPL WTRGQPSSPS PLAYMLSLYR DPLPRADIIR 
SLQAQDVDVT GQNWTFTFDF SFLSQEEDLV WAELRLQLPG PMDIPTEGPL TIDIFHQAKG 
DPERDPADCL ERIWMETFTV IPSQVTFASG STVLEVTKPL SKWLKDPRAL EKQVSSRAEK 
CWHQPYTPPV PVASTNVLML YSNRPQEQRQ LGGATLLWEA ESSWRAQEGQ LSVERGGWGR 
RQRRHHLPDR SQLCRRVKFQ VDFNLIGWGS WIIYPKQYNA YRCEGECPNP VGEEFHPTNH 
AYIQSLLKRY QPHRVPSTCC APVKTKPLSM LYVDNGRVLL EHHKDMIVEE CGCL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.