Details for: Nr4a3

Gene ID: 18124

Symbol: Nr4a3

Ensembl ID: ENSMUSG00000028341

Description: nuclear receptor subfamily 4, group A, member 3

Associated with

  • Gene expression (transcription)
    (R-MMU-74160)
  • Generic transcription pathway
    (R-MMU-212436)
  • Nuclear receptor transcription pathway
    (R-MMU-383280)
  • Rna polymerase ii transcription
    (R-MMU-73857)
  • Adult behavior
    (GO:0030534)
  • Axon guidance
    (GO:0007411)
  • Camp response element binding
    (GO:0035497)
  • Cell cycle
    (GO:0007049)
  • Cellular respiration
    (GO:0045333)
  • Cellular response to catecholamine stimulus
    (GO:0071870)
  • Cellular response to corticotropin-releasing hormone stimulus
    (GO:0071376)
  • Cellular response to leptin stimulus
    (GO:0044320)
  • Common myeloid progenitor cell proliferation
    (GO:0035726)
  • Dendritic cell apoptotic process
    (GO:0097048)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Energy homeostasis
    (GO:0097009)
  • Fat cell differentiation
    (GO:0045444)
  • Gastrulation
    (GO:0007369)
  • Hippocampus development
    (GO:0021766)
  • Histone acetyltransferase binding
    (GO:0035035)
  • Inner ear morphogenesis
    (GO:0042472)
  • Intracellular signal transduction
    (GO:0035556)
  • Mast cell degranulation
    (GO:0043303)
  • Mesoderm formation
    (GO:0001707)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Negative regulation of smooth muscle cell apoptotic process
    (GO:0034392)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuromuscular process controlling balance
    (GO:0050885)
  • Neuron apoptotic process
    (GO:0051402)
  • Nuclear glucocorticoid receptor binding
    (GO:0035259)
  • Nuclear receptor activity
    (GO:0004879)
  • Nucleus
    (GO:0005634)
  • Platelet-derived growth factor receptor signaling pathway
    (GO:0048008)
  • Positive regulation of cardiac muscle hypertrophy
    (GO:0010613)
  • Positive regulation of cell cycle
    (GO:0045787)
  • Positive regulation of dendritic cell apoptotic process
    (GO:2000670)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of epithelial cell proliferation
    (GO:0050679)
  • Positive regulation of fatty acid oxidation
    (GO:0046321)
  • Positive regulation of feeding behavior
    (GO:2000253)
  • Positive regulation of glucose transmembrane transport
    (GO:0010828)
  • Positive regulation of mast cell activation by fc-epsilon receptor signaling pathway
    (GO:0038097)
  • Positive regulation of mast cell cytokine production
    (GO:0032765)
  • Positive regulation of monocyte aggregation
    (GO:1900625)
  • Positive regulation of smooth muscle cell proliferation
    (GO:0048661)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of vascular associated smooth muscle cell migration
    (GO:1904754)
  • Positive regulation of vascular associated smooth muscle cell proliferation
    (GO:1904707)
  • Protein homodimerization activity
    (GO:0042803)
  • Protein kinase binding
    (GO:0019901)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of smooth muscle cell proliferation
    (GO:0048660)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Regulation of type b pancreatic cell proliferation
    (GO:0061469)
  • Response to hydrogen peroxide
    (GO:0042542)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Semicircular canal morphogenesis
    (GO:0048752)
  • Sequence-specific dna binding
    (GO:0043565)
  • Smooth muscle cell apoptotic process
    (GO:0034390)
  • Transcription coactivator binding
    (GO:0001223)
  • Transcription regulator complex
    (GO:0005667)
  • Vestibular reflex
    (GO:0060005)
  • Zinc ion binding
    (GO:0008270)

Other Information

Genular Protein ID: 1081270108

Symbol: NR4A3_MOUSE

Name: Nuclear receptor subfamily 4 group A member 3

UniProtKB Accession Codes:

Q9QZB6 Q9QZB5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 60 Gene3D 2 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 4 PRO 1 PROSITE 3 PROSITE-ProRule 2 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 5 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 2 UniProtKB 2 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 10701778

Title: Structure and expression of the mouse gene encoding the orphan nuclear receptor TEC.

PubMed ID: 10701778

DOI: 10.1089/104454900314636

PubMed ID: 11784868

Title: The nuclear receptor Nor-1 is essential for proliferation of the semicircular canals of the mouse inner ear.

PubMed ID: 11784868

DOI: 10.1128/mcb.22.3.935-945.2002

PubMed ID: 12709428

Title: The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine.

PubMed ID: 12709428

DOI: 10.1074/jbc.m300088200

PubMed ID: 13129926

Title: The orphan steroid receptor Nur77 family member Nor-1 is essential for early mouse embryogenesis.

PubMed ID: 13129926

DOI: 10.1074/jbc.m307496200

PubMed ID: 15456880

Title: nor-1 regulates hippocampal axon guidance, pyramidal cell survival, and seizure susceptibility.

PubMed ID: 15456880

DOI: 10.1128/mcb.24.20.9070-9078.2004

PubMed ID: 18325999

Title: The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle.

PubMed ID: 18325999

DOI: 10.1210/en.2007-1202

PubMed ID: 18945812

Title: Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1.

PubMed ID: 18945812

DOI: 10.1210/me.2008-0161

PubMed ID: 19523439

Title: Serotonin 5-HT2C receptor-independent expression of hypothalamic NOR1, a novel modulator of food intake and energy balance, in mice.

PubMed ID: 19523439

DOI: 10.1016/j.bbrc.2009.06.023

PubMed ID: 19153266

Title: Deficiency of the NR4A neuron-derived orphan receptor-1 attenuates neointima formation after vascular injury.

PubMed ID: 19153266

DOI: 10.1161/circulationaha.108.822056

PubMed ID: 20558821

Title: Deficiency of the NR4A orphan nuclear receptor NOR1 decreases monocyte adhesion and atherosclerosis.

PubMed ID: 20558821

DOI: 10.1161/circresaha.110.222083

PubMed ID: 20566846

Title: NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection.

PubMed ID: 20566846

DOI: 10.1073/pnas.1007088107

PubMed ID: 21868379

Title: Transcriptional regulation of S phase kinase-associated protein 2 by NR4A orphan nuclear receptor NOR1 in vascular smooth muscle cells.

PubMed ID: 21868379

DOI: 10.1074/jbc.m111.295840

PubMed ID: 23897430

Title: Control of energy balance by hypothalamic gene circuitry involving two nuclear receptors, neuron-derived orphan receptor 1 and glucocorticoid receptor.

PubMed ID: 23897430

DOI: 10.1128/mcb.00385-13

PubMed ID: 24586680

Title: Nuclear receptor 4a3 (nr4a3) regulates murine mast cell responses and granule content.

PubMed ID: 24586680

DOI: 10.1371/journal.pone.0089311

PubMed ID: 24806827

Title: Deficiency of the NR4A orphan nuclear receptor NOR1 in hematopoietic stem cells accelerates atherosclerosis.

PubMed ID: 24806827

DOI: 10.1002/stem.1747

Sequence Information:

  • Length: 627
  • Mass: 68454
  • Checksum: 2F49CB4C8DE315A8
  • Sequence:
    • MPCVQAQYSP SPPGSTYATQ TYGSEYTTEI MNPDYTKLTM DLGSTGIMAT ATTSLPSFST 
FMEGYPSSCE LKPSCLYQMP PSGPRPLIKM EEGREHGYHH HHHHHHHHHH HQQQQPSIPP 
PSGPEDEVLP STSMYFKQSP PSTPTTPGFP PQAGALWDDE LPSAPGCIAP GPLLDPQMKA 
VPPMAAAARF PIFFKPSPPH PPAPSPAGGH HLGYDPTAAA ALSLPLGAAA AAGSQAAALE 
GHPYGLPLAK RTATLTFPPL GLTASPTASS LLGESPSLPS PPNRSSSSGE GTCAVCGDNA 
ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL ANKNCPVDKR RRNRCQYCRF QKCLSVGMVK 
EVVRTDSLKG RRGRLPSKPK SPLQQEPSQP SPPSPPICMM NALVRALTDA TPRDLDYSRY 
CPTDQATAGT DAEHVQQFYN LLTASIDVSR SWAEKIPGFT DLPKEDQTLL IESAFLELFV 
LRLSIRSNTA EDKFVFCNGL VLHRLQCLRG FGEWLDSIKD FSLNLQSLNL DIQALACLSA 
LSMITERHGL KEPKRVEELC TKITSSLKDH QRKGQALEPS EPKVLRALVE LRKICTQGLQ 
RIFYLKLEDL VPPPSVIDKL FLDTLPF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.