Genular: Defining Cellular Identity and Function

Details for: Nos1

Gene ID: 18125

Symbol: Nos1

Ensembl ID: ENSMUSG00000029361

Description: nitric oxide synthase 1, neuronal

Associated with

Cardiac conduction
(R-MMU-5576891)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Ion homeostasis
(R-MMU-5578775)
Nitric oxide stimulates guanylate cyclase
(R-MMU-392154)
Platelet homeostasis
(R-MMU-418346)
Ros and rns production in phagocytes
(R-MMU-1222556)
Arginine catabolic process
(GO:0006527)
Atpase binding
(GO:0051117)
Behavioral response to cocaine
(GO:0048148)
Cadmium ion binding
(GO:0046870)
Calcium-dependent protein binding
(GO:0048306)
Calcium ion transport
(GO:0006816)
Calmodulin binding
(GO:0005516)
Caveola
(GO:0005901)
Cellular response to epinephrine stimulus
(GO:0071872)
Cellular response to growth factor stimulus
(GO:0071363)
Cellular response to mechanical stimulus
(GO:0071260)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Enzyme binding
(GO:0019899)
Establishment of localization in cell
(GO:0051649)
Establishment of protein localization
(GO:0045184)
Flavin adenine dinucleotide binding
(GO:0050660)
Fmn binding
(GO:0010181)
Heme binding
(GO:0020037)
Identical protein binding
(GO:0042802)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion
(GO:0005739)
Multicellular organismal response to stress
(GO:0033555)
Muscle contraction
(GO:0006936)
Nadp binding
(GO:0050661)
Nadph binding
(GO:0070402)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of blood pressure
(GO:0045776)
Negative regulation of calcium ion transport
(GO:0051926)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of cytosolic calcium ion concentration
(GO:0051481)
Negative regulation of hepatic stellate cell contraction
(GO:0061875)
Negative regulation of hydrolase activity
(GO:0051346)
Negative regulation of insulin secretion
(GO:0046676)
Negative regulation of iron ion transmembrane transport
(GO:0034760)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of peptidyl-serine phosphorylation
(GO:0033137)
Negative regulation of potassium ion transport
(GO:0043267)
Negative regulation of serotonin uptake
(GO:0051612)
Negative regulation of vasoconstriction
(GO:0045906)
Nitric-oxide synthase activity
(GO:0004517)
Nitric oxide biosynthetic process
(GO:0006809)
Nitric oxide mediated signal transduction
(GO:0007263)
Nuclear membrane
(GO:0031965)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Oxidoreductase activity
(GO:0016491)
Peptidyl-cysteine s-nitrosylation
(GO:0018119)
Phosphoprotein binding
(GO:0051219)
Photoreceptor inner segment
(GO:0001917)
Plasma membrane
(GO:0005886)
Positive regulation of adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0106071)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of guanylate cyclase activity
(GO:0031284)
Positive regulation of long-term synaptic potentiation
(GO:1900273)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of sodium ion transmembrane transport
(GO:1902307)
Positive regulation of the force of heart contraction
(GO:0098735)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Postsynaptic density
(GO:0014069)
Potassium ion transport
(GO:0006813)
Protein binding
(GO:0005515)
Regulation of neurogenesis
(GO:0050767)
Regulation of postsynaptic membrane potential
(GO:0060078)
Regulation of sodium ion transport
(GO:0002028)
Response to estrogen
(GO:0043627)
Response to heat
(GO:0009408)
Response to hormone
(GO:0009725)
Response to lipopolysaccharide
(GO:0032496)
Response to peptide hormone
(GO:0043434)
Retrograde trans-synaptic signaling by nitric oxide
(GO:0098924)
Sarcoplasmic reticulum
(GO:0016529)
Scaffold protein binding
(GO:0097110)
Secretory granule
(GO:0030141)
Sodium channel regulator activity
(GO:0017080)
Striated muscle contraction
(GO:0006941)
Synaptic signaling by nitric oxide
(GO:0099163)
T-tubule
(GO:0030315)
Transmembrane transporter binding
(GO:0044325)
Vasodilation
(GO:0042311)
Xenobiotic catabolic process
(GO:0042178)
Z disc
(GO:0030018)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Constitutive NOS

Genular Protein ID: 2095967012

Symbol: NOS1_MOUSE

Name: Constitutive NOS

UniProtKB Accession Codes:

Q9Z0J4 Q3UR10 Q64208

Database IDs:

Citations:

PubMed ID: 7686743

Title: Structural diversity of neuronal oxide synthase mRNA in the nervous system.

PubMed ID: 7686743

DOI: 10.1006/bbrc.1993.1726

PubMed ID: 8626668

Title: Neuronal nitric-oxide synthase-mu, an alternatively spliced isoform expressed in differentiated skeletal muscle.

PubMed ID: 8626668

DOI: 10.1074/jbc.271.19.11204

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 7545544

Title: Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy.

PubMed ID: 7545544

DOI: 10.1016/0092-8674(95)90471-9

PubMed ID: 9208206

Title: Regulation of neuronal nitric oxide synthase through alternative transcripts.

PubMed ID: 9208206

DOI: 10.1159/000111211

PubMed ID: 10623522

Title: Solution structure and backbone dynamics of the second PDZ domain of postsynaptic density-95.

PubMed ID: 10623522

DOI: 10.1006/jmbi.1999.3350

PubMed ID: 11086993

Title: Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON.

PubMed ID: 11086993

DOI: 10.1016/s0896-6273(00)00095-7

PubMed ID: 15466885

Title: New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting.

PubMed ID: 15466885

DOI: 10.1242/jcs.01379

PubMed ID: 17293453

Title: Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation.

PubMed ID: 17293453

DOI: 10.1073/pnas.0611620104

PubMed ID: 17452640

Title: Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity.

PubMed ID: 17452640

DOI: 10.1073/pnas.0610964104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22081021

Title: Requirement of argininosuccinate lyase for systemic nitric oxide production.

PubMed ID: 22081021

DOI: 10.1038/nm.2544

Sequence Information:

Length: 1429
Mass: 160472
Checksum: 3782848D65B41BFC
Sequence:

MEEHTFGVQQ IQPNVISVRL FKRKVGGLGF LVKERVSKPP VIISDLIRGG AAEQSGLIQA 
GDIILAVNDR PLVDLSYDSA LEVLRGIASE THVVLILRGP EGFTTHLETT FTGDGTPKTI 
RVTQPLGTPT KAVDLSRQPS ASKDQPLAVD RVPGPSNGPQ HAQGRGQGAG SVSQANGVAI 
DPTMKNTKAN LQDSGEQDEL LKEIEPVLSI LTGGGKAVNR GGPAKAEMKD TGIQVDRDLD 
GKLHKAPPLG GENDRVFNDL WGKGNVPVVL NNPYSENEQS PASGKQSPTK NGSPSRCPRF 
LKVKNWETDV VLTDTLHLKS TLETGCTEQI CMGSIMLPSH HIRKSEDVRT KDQLFPLAKE 
FLDQYYSSIK RFGSKAHMDR LEEVNKEIES TSTYQLKDTE LIYGAKHAWR NASRCVGRIQ 
WSKLQVFDAR DCTTAHGMFN YICNHVKYAT NKGNLRSAIT IFPQRTDGKH DFRVWNSQLI 
RYAGYKQPDG STLGDPANVE FTEICIQQGW KPPRGRFDVL PLLLQANGND PELFQIPPEL 
VLEVPIRHPK FDWFKDLGLK WYGLPAVSNM LLEIGGLEFS ACPFSGWYMG TEIGVRDYCD 
NSRYNILEEV AKKMDLDMRK TSSLWKDQAL VEINIAVLYS FQSDKVTIVD HHSATESFIK 
HMENEYRCRG GCPADWVWIV PPMSGSITPV FHQEMLNYRL TPSFEYQPDP WNTHVWKGTN 
GTPTKRRAIG FKKLAEAVKF SAKLMGQAMA KRVKATILYA TETGKSQAYA KTLCEIFKHA 
FDAKAMSMEE YDIVHLEHEA LVLVVTSTFG NGDPPENGEK FGCALMEMRH PNSVQEERKS 
YKVRFNSVSS YSDSRKSSGD GPDLRDNFES TGPLANVRFS VFGLGSRAYP HFCAFGHAVD 
TLLEELGGER ILKMREGDEL CGQEEAFRTW AKKVFKAACD VFCVGDDVNI EKANNSLISN 
DRSWKRNKFR LTYVAEAPEL TQGLSNVHKK RVSAARLLSR QNLQSPKSSR STIFVRLHTN 
GNQELQYQPG DHLGVFPGNH EDLVNALIER LEDAPPANHV VKVEMLEERN TALGVISNWK 
DESRLPPCTI FQAFKYYLDI TTPPTPLQLQ QFASLATNEK EKQRLLVLSK GLQEYEEWKW 
GKNPTMVEVL EEFPSIQMPA TLLLTQLSLL QPRYYSISSS PDMYPDEVHL TVAIVSYHTR 
DGEGPVHHGV CSSWLNRIQA DDVVPCFVRG APSFHLPRNP QVPCILVGPG TGIAPFRSFW 
QQRQFDIQHK GMNPCPMVLV FGCRQSKIDH IYREETLQAK NKGVFRELYT AYSREPDRPK 
KYVQDVLQEQ LAESVYRALK EQGGHIYVCG DVTMAADVLK AIQRIMTQQG KLSEEDAGVF 
ISRLRDDNRY HEDIFGVTLR TYEVTNRLRS ESIAFIEESK KDTDEVFSS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nos1

Associated with

Other Information

Structural diversity of neuronal oxide synthase mRNA in the nervous system. PubMed ID: 7686743

Neuronal nitric-oxide synthase-mu, an alternatively spliced isoform expressed in differentiated skeletal muscle. PubMed ID: 8626668

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy. PubMed ID: 7545544

Regulation of neuronal nitric oxide synthase through alternative transcripts. PubMed ID: 9208206

Solution structure and backbone dynamics of the second PDZ domain of postsynaptic density-95. PubMed ID: 10623522

Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON. PubMed ID: 11086993

New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting. PubMed ID: 15466885

Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation. PubMed ID: 17293453

Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity. PubMed ID: 17452640

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Requirement of argininosuccinate lyase for systemic nitric oxide production. PubMed ID: 22081021