Genular: Defining Cellular Identity and Function

Details for: Nos2

Gene ID: 18126

Symbol: Nos2

Ensembl ID: ENSMUSG00000020826

Description: nitric oxide synthase 2, inducible

Associated with

Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Nitric oxide stimulates guanylate cyclase
(R-MMU-392154)
Peroxisomal protein import
(R-MMU-9033241)
Platelet homeostasis
(R-MMU-418346)
Protein localization
(R-MMU-9609507)
Ros and rns production in phagocytes
(R-MMU-1222556)
Actin binding
(GO:0003779)
Arginine binding
(GO:0034618)
Arginine catabolic process
(GO:0006527)
Beta-catenin binding
(GO:0008013)
Blood vessel remodeling
(GO:0001974)
Cadherin binding
(GO:0045296)
Calmodulin binding
(GO:0005516)
Camp-dependent protein kinase regulator activity
(GO:0008603)
Cellular response to cytokine stimulus
(GO:0071345)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to organic cyclic compound
(GO:0071407)
Cellular response to type ii interferon
(GO:0071346)
Cellular response to xenobiotic stimulus
(GO:0071466)
Cgmp-mediated signaling
(GO:0019934)
Circadian rhythm
(GO:0007623)
Cortical cytoskeleton
(GO:0030863)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to bacterium
(GO:0042742)
Extracellular space
(GO:0005615)
Flavin adenine dinucleotide binding
(GO:0050660)
Fmn binding
(GO:0010181)
G protein-coupled receptor signaling pathway coupled to cgmp nucleotide second messenger
(GO:0007199)
Heme binding
(GO:0020037)
Hsp90 protein binding
(GO:0051879)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Intracellular signal transduction
(GO:0035556)
Metal ion binding
(GO:0046872)
Nadp binding
(GO:0050661)
Negative regulation of blood pressure
(GO:0045776)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of protein catabolic process
(GO:0042177)
Nitric-oxide synthase activity
(GO:0004517)
Nitric-oxide synthase binding
(GO:0050998)
Nitric oxide biosynthetic process
(GO:0006809)
Nitric oxide mediated signal transduction
(GO:0007263)
Nucleus
(GO:0005634)
Ovulation from ovarian follicle
(GO:0001542)
Oxidoreductase activity
(GO:0016491)
Peptidyl-cysteine s-nitrosylation
(GO:0018119)
Perinuclear region of cytoplasm
(GO:0048471)
Peroxisome
(GO:0005777)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of guanylate cyclase activity
(GO:0031284)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of killing of cells of another organism
(GO:0051712)
Prostaglandin secretion
(GO:0032310)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Regulation of blood pressure
(GO:0008217)
Regulation of cell population proliferation
(GO:0042127)
Regulation of cytokine production involved in inflammatory response
(GO:1900015)
Regulation of insulin secretion
(GO:0050796)
Response to bacterium
(GO:0009617)
Response to hormone
(GO:0009725)
Response to hypoxia
(GO:0001666)
Response to lipopolysaccharide
(GO:0032496)
Response to tumor necrosis factor
(GO:0034612)
Superoxide metabolic process
(GO:0006801)
Tetrahydrobiopterin binding
(GO:0034617)

Other Information

Proteins

Nitric oxide synthase, inducible

Genular Protein ID: 2185657001

Symbol: NOS2_MOUSE

Name: Nitric oxide synthase, inducible

UniProtKB Accession Codes:

P29477 O70515 O70516 Q5SXT3 Q6P6A0 Q8R410

Database IDs:

Citations:

PubMed ID: 1373522

Title: Cloning and characterization of inducible nitric oxide synthase from mouse macrophages.

PubMed ID: 1373522

DOI: 10.1126/science.1373522

PubMed ID: 1379716

Title: Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.

PubMed ID: 1379716

DOI: 10.1073/pnas.89.15.6711

PubMed ID: 1372907

Title: Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

PubMed ID: 1372907

DOI: 10.1016/s0021-9258(18)42704-4

PubMed ID: 7503239

Title: Role of NF-kappa B in the regulation of inducible nitric oxide synthase in an MTAL cell line.

PubMed ID: 7503239

DOI: 10.1152/ajprenal.1995.269.5.f718

PubMed ID: 10438970

Title: Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis.

PubMed ID: 10438970

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7544010

Title: The mode of action of aspirin-like drugs: effect on inducible nitric oxide synthase.

PubMed ID: 7544010

DOI: 10.1073/pnas.92.17.7926

PubMed ID: 16373578

Title: Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2.

PubMed ID: 16373578

DOI: 10.1126/science.1119407

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 20603330

Title: The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation.

PubMed ID: 20603330

DOI: 10.1083/jcb.200912087

PubMed ID: 21199876

Title: Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins.

PubMed ID: 21199876

DOI: 10.1074/jbc.m110.190678

PubMed ID: 22081021

Title: Requirement of argininosuccinate lyase for systemic nitric oxide production.

PubMed ID: 22081021

DOI: 10.1038/nm.2544

PubMed ID: 22073225

Title: The circadian deadenylase Nocturnin is necessary for stabilization of the iNOS mRNA in mice.

PubMed ID: 22073225

DOI: 10.1371/journal.pone.0026954

PubMed ID: 9334294

Title: The structure of nitric oxide synthase oxygenase domain and inhibitor complexes.

PubMed ID: 9334294

DOI: 10.1126/science.278.5337.425

PubMed ID: 9516116

Title: Structure of nitric oxide synthase oxygenase dimer with pterin and substrate.

PubMed ID: 9516116

DOI: 10.1126/science.279.5359.2121

PubMed ID: 10562538

Title: Inducible nitric oxide synthase: role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction.

PubMed ID: 10562538

DOI: 10.1093/emboj/18.22.6260

PubMed ID: 10562539

Title: N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization.

PubMed ID: 10562539

DOI: 10.1093/emboj/18.22.6271

PubMed ID: 10769116

Title: Structures of the N(omega)-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins.

PubMed ID: 10769116

DOI: 10.1021/bi992409a

PubMed ID: 11669619

Title: Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457.

PubMed ID: 11669619

DOI: 10.1021/bi011183k

PubMed ID: 12437348

Title: Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency.

PubMed ID: 12437348

DOI: 10.1021/bi026313j

PubMed ID: 12464241

Title: Crystal structures of cyanide complexes of P450cam and the oxygenase domain of inducible nitric oxide synthase -- structural models of the short-lived oxygen complexes.

PubMed ID: 12464241

DOI: 10.1016/s0003-9861(02)00555-6

Sequence Information:

Length: 1144
Mass: 130575
Checksum: 0735BE676113457F
Sequence:

MACPWKFLFK VKSYQSDLKE EKDINNNVKK TPCAVLSPTI QDDPKSHQNG SPQLLTGTAQ 
NVPESLDKLH VTSTRPQYVR IKNWGSGEIL HDTLHHKATS DFTCKSKSCL GSIMNPKSLT 
RGPRDKPTPL EELLPHAIEF INQYYGSFKE AKIEEHLARL EAVTKEIETT GTYQLTLDEL 
IFATKMAWRN APRCIGRIQW SNLQVFDARN CSTAQEMFQH ICRHILYATN NGNIRSAITV 
FPQRSDGKHD FRLWNSQLIR YAGYQMPDGT IRGDAATLEF TQLCIDLGWK PRYGRFDVLP 
LVLQADGQDP EVFEIPPDLV LEVTMEHPKY EWFQELGLKW YALPAVANML LEVGGLEFPA 
CPFNGWYMGT EIGVRDFCDT QRYNILEEVG RRMGLETHTL ASLWKDRAVT EINVAVLHSF 
QKQNVTIMDH HTASESFMKH MQNEYRARGG CPADWIWLVP PVSGSITPVF HQEMLNYVLS 
PFYYYQIEPW KTHIWQNEKL RPRRREIRFR VLVKVVFFAS MLMRKVMASR VRATVLFATE 
TGKSEALARD LATLFSYAFN TKVVCMDQYK ASTLEEEQLL LVVTSTFGNG DCPSNGQTLK 
KSLFMLRELN HTFRYAVFGL GSSMYPQFCA FAHDIDQKLS HLGASQLAPT GEGDELSGQE 
DAFRSWAVQT FRAACETFDV RSKHHIQIPK RFTSNATWEP QQYRLIQSPE PLDLNRALSS 
IHAKNVFTMR LKSQQNLQSE KSSRTTLLVQ LTFEGSRGPS YLPGEHLGIF PGNQTALVQG 
ILERVVDCPT PHQTVCLEVL DESGSYWVKD KRLPPCSLSQ ALTYFLDITT PPTQLQLHKL 
ARFATDETDR QRLEALCQPS EYNDWKFSNN PTFLEVLEEF PSLHVPAAFL LSQLPILKPR 
YYSISSSQDH TPSEVHLTVA VVTYRTRDGQ GPLHHGVCST WIRNLKPQDP VPCFVRSVSG 
FQLPEDPSQP CILIGPGTGI APFRSFWQQR LHDSQHKGLK GGRMSLVFGC RHPEEDHLYQ 
EEMQEMVRKR VLFQVHTGYS RLPGKPKVYV QDILQKQLAN EVLSVLHGEQ GHLYICGDVR 
MARDVATTLK KLVATKLNLS EEQVEDYFFQ LKSQKRYHED IFGAVFSYGA KKGSALEEPK 
ATRL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nos2

Associated with

Other Information

Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. PubMed ID: 1373522

Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme. PubMed ID: 1379716

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. PubMed ID: 1372907

Role of NF-kappa B in the regulation of inducible nitric oxide synthase in an MTAL cell line. PubMed ID: 7503239

Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis. PubMed ID: 10438970

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The mode of action of aspirin-like drugs: effect on inducible nitric oxide synthase. PubMed ID: 7544010

Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. PubMed ID: 16373578

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation. PubMed ID: 20603330

Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins. PubMed ID: 21199876

Requirement of argininosuccinate lyase for systemic nitric oxide production. PubMed ID: 22081021

The circadian deadenylase Nocturnin is necessary for stabilization of the iNOS mRNA in mice. PubMed ID: 22073225

The structure of nitric oxide synthase oxygenase domain and inhibitor complexes. PubMed ID: 9334294

Structure of nitric oxide synthase oxygenase dimer with pterin and substrate. PubMed ID: 9516116

Inducible nitric oxide synthase: role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction. PubMed ID: 10562538

N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization. PubMed ID: 10562539

Structures of the N(omega)-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins. PubMed ID: 10769116

Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457. PubMed ID: 11669619

Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency. PubMed ID: 12437348

Crystal structures of cyanide complexes of P450cam and the oxygenase domain of inducible nitric oxide synthase -- structural models of the short-lived oxygen complexes. PubMed ID: 12464241