Genular: Defining Cellular Identity and Function

Details for: Nos3

Gene ID: 18127

Symbol: Nos3

Ensembl ID: ENSMUSG00000028978

Description: nitric oxide synthase 3, endothelial cell

Associated with

Enos activation
(R-MMU-203615)
Esr-mediated signaling
(R-MMU-8939211)
Extra-nuclear estrogen signaling
(R-MMU-9009391)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Metabolism
(R-MMU-1430728)
Metabolism of cofactors
(R-MMU-8978934)
Metabolism of nitric oxide: nos3 activation and regulation
(R-MMU-202131)
Metabolism of vitamins and cofactors
(R-MMU-196854)
Nitric oxide stimulates guanylate cyclase
(R-MMU-392154)
Nosip mediated enos trafficking
(R-MMU-203754)
Nostrin mediated enos trafficking
(R-MMU-203641)
Platelet homeostasis
(R-MMU-418346)
Ros and rns production in phagocytes
(R-MMU-1222556)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by vegf
(R-MMU-194138)
Signal transduction
(R-MMU-162582)
Tetrahydrobiopterin (bh4) synthesis, recycling, salvage and regulation
(R-MMU-1474151)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Vegfr2 mediated vascular permeability
(R-MMU-5218920)
Actin binding
(GO:0003779)
Actin monomer binding
(GO:0003785)
Angiogenesis
(GO:0001525)
Aortic valve morphogenesis
(GO:0003180)
Arginine binding
(GO:0034618)
Arginine catabolic process
(GO:0006527)
Beta-catenin binding
(GO:0008013)
Blood vessel diameter maintenance
(GO:0097746)
Blood vessel remodeling
(GO:0001974)
Cadherin binding
(GO:0045296)
Calcium ion transport
(GO:0006816)
Calmodulin binding
(GO:0005516)
Caveola
(GO:0005901)
Cellular response to mechanical stimulus
(GO:0071260)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Endocardial cushion morphogenesis
(GO:0003203)
Endothelial cell migration
(GO:0043542)
Establishment of localization in cell
(GO:0051649)
Flavin adenine dinucleotide binding
(GO:0050660)
Fmn binding
(GO:0010181)
Golgi apparatus
(GO:0005794)
Heme binding
(GO:0020037)
Homeostasis of number of cells within a tissue
(GO:0048873)
Hsp90 protein binding
(GO:0051879)
In utero embryonic development
(GO:0001701)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Lung development
(GO:0030324)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Nadp binding
(GO:0050661)
Negative regulation of biomineral tissue development
(GO:0070168)
Negative regulation of blood pressure
(GO:0045776)
Negative regulation of calcium ion transport
(GO:0051926)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of hydrolase activity
(GO:0051346)
Negative regulation of muscle hyperplasia
(GO:0014740)
Negative regulation of potassium ion transport
(GO:0043267)
Negative regulation of smooth muscle cell proliferation
(GO:0048662)
Nitric-oxide synthase activity
(GO:0004517)
Nitric-oxide synthase binding
(GO:0050998)
Nitric oxide biosynthetic process
(GO:0006809)
Nitric oxide mediated signal transduction
(GO:0007263)
Nucleus
(GO:0005634)
Ovulation from ovarian follicle
(GO:0001542)
Oxidoreductase activity
(GO:0016491)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of blood vessel endothelial cell migration
(GO:0043536)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of guanylate cyclase activity
(GO:0031284)
Potassium ion transport
(GO:0006813)
Protein binding
(GO:0005515)
Pulmonary valve morphogenesis
(GO:0003184)
Regulation of nervous system process
(GO:0031644)
Regulation of sodium ion transport
(GO:0002028)
Regulation of systemic arterial blood pressure by endothelin
(GO:0003100)
Regulation of the force of heart contraction by chemical signal
(GO:0003057)
Removal of superoxide radicals
(GO:0019430)
Response to estradiol
(GO:0032355)
Response to hormone
(GO:0009725)
Response to lipopolysaccharide
(GO:0032496)
Sarcolemma
(GO:0042383)
Scaffold protein binding
(GO:0097110)
Smooth muscle hyperplasia
(GO:0014806)
Tetrahydrobiopterin binding
(GO:0034617)
Ventricular septum morphogenesis
(GO:0060412)

Other Information

Proteins

Constitutive NOS
Q8C5P3_MOUSE

Genular Protein ID: 3895477892

Symbol: NOS3_MOUSE

Name: Constitutive NOS

UniProtKB Accession Codes:

P70313 O55056 Q7TSV7

Database IDs:

Citations:

PubMed ID: 8764825

Title: Cloning and characterization of murine endothelial constitutive nitric oxide synthase.

PubMed ID: 8764825

DOI: 10.1016/0167-4781(96)00098-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9843834

Title: Limb reduction defects in endothelial nitric oxide synthase-deficient mice.

PubMed ID: 9843834

DOI: 10.1152/ajpheart.1998.275.6.h2319

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22081021

Title: Requirement of argininosuccinate lyase for systemic nitric oxide production.

PubMed ID: 22081021

DOI: 10.1038/nm.2544

Sequence Information:

Length: 1202
Mass: 132916
Checksum: E1F65C43601F0937
Sequence:

MGNLKSVGQE PGPPCGLGLG LGLGLCGKQG PASPAPEPSQ APAPPSPTRP APDHSPPLTR 
PPDGPRFPRV KNWEVGSITY DTLSAQAQQD GPCTSRRCLG SLVFPRKLQS RPTQGPSPTE 
QLLGQARDFI NQYYNSIKRS GSQAHEQRLQ EVEAEVAATG TYQLRESELV FGAKQAWRNA 
PRCVGRIQWG KLQVFDARDC RTAQEMFTYI CNHIKYATNR GNLRSAITVF PQRCPGRGDF 
RIWNSQLIRY AGYRQQDGSV RGDPANVEIT ELCIQHGWTP GNGRFDVLPL LLQAPDEPPE 
LFTLPPEMVL EVPLEHPTLE WFAALGLRWY ALPAVSNMLL EIGGLEFPAA PFSGWYMSSE 
IGMRDLCDPH RYNILEDVAV CMDLDTRTTS SLWKDKAAVE INVAVLHSYQ LAKVTIVDHH 
AATASFMKHL ENEQKARGGC PADWAWIVPP ISGSLTPVFH QEMVNYFLSP AFRYQPDPWK 
GSAAKGAGIT RKKTFKEVAN AVKISASLMG TVMAKRVKAT ILYGSETGRA QSYAQQLGRL 
FRKAFDPRVL CMDEYDVVSL EHEALVLVVT STFGNGDPPE NGESFAAALM EMSGPYNSSP 
RPEQHKSYKI RFNSVSCSDP LVSSWRRKRK ESSNTDSAGA LGTLRFCVFG LGSRAYPHFC 
AFARAVDTRL EELGGERLLQ LGQGDELCGQ EEAFRGWAQA AFQAACETFC VGEDAKAAAR 
DIFSPKRSWK RQRYRLSTQA ESLQLLPGLT HVHRRKMFQA TILSVENLQS SKSTRATILV 
RLDTGGQEGL QYQPGDHIGV CPPNRPGLVE ALLSRVEDPP PSTEPVAVEQ LEKGSPGGPP 
PGWVRDPRLP PCTLRQALTY FLDITSPPSP RLLRLLSTLA EESSEQQELE ALSQDPRRYE 
EWKWFSCPTL LEVLEQFPSV ALPAPLILTQ LPLLQPRYYS VSSAPSAHPG EIHLTIAVLA 
YRTQDGLGPL HYGVCSTWMS QLKAGDPVPC FIRGAPSFRL PPDPNLPCIL VGPGTGIAPF 
RGFWQDRLHD IEIKGLQPAP MTLVFGCRCS QLDHLYRDEV LDAQQRGVFG QVLTAFSRDP 
GSPKTYVQDL LRTELAAEVH RVLCLEQGHM FVCGDVTMAT SVLQTVQRIL ATEGGMELDE 
AGDVIGVLRD QQRYHEDIFG LTLRTQEVTS RIRTQSFSLQ ERQLRGAVPW SFDPPGPEIP 
GS

Genular Protein ID: 373405009

Symbol: Q8C5P3_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8C5P3

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 1202
Mass: 132872
Checksum: F3CC089611D24B1E
Sequence:

MGNLKSVGQE PGPPCGLGLG LGLGLCGKQG PASPAPEPSQ APAPPSPTRP APDHSPPLTR 
PPDGPRFPRV KNWEVGSITY DTLSAQAQQD GPCTSRRCLG SLVFPRKLQS RPTQGPSPTE 
QLLGQARDFI NQYYNSIKRS GSQAHEQRLQ EVEAEVAATG TYQLRESELV FGAKQAWRNA 
PRCVGRIQWG KLQVFDARDC RTAQEMFTYI CNHIKYATNR GNLRSAITVF PQRCPGRGDF 
RIWNSQLIRY AGYRQQDGSV RGDPANVEIT ELCIQHGWTP GNGRFDVLPL LLQAPDEPPE 
LFTLPPEMVL EVPLEHPTLE WFAALGLRWY ALPAVSNMLL EIGGLEFPAA PFSGWYMSSE 
IGMRDLCDPH RYNILEDVAV CMDLDTRTTS SLWKDKAAVE INVAVLHSYQ LAKVTIVDHH 
AATASFMKHL ENEQKARGGC PADWAWIVPP ISGSLTPVFH QEMVNYFLSP AFRYQPDPWK 
GSAAKGAGIT RKKTFKEVAN AVKVSASLMG TVMAKRVKAT ILYGSEAGRA QSYAQQLGRL 
FRKAFDPRVL CMDEYDVVSL EHEALVLVVT STFGNGDPPE NGESFAAALM EMSGPYNSSP 
RPEQHKSYKI RFNSVSCSDP LVSSWRRKRK ESSNTDSAGA LGTLRFCVFG LGSRAYPHFC 
AFARAVDTRL EELGGERLLQ LGQGDELCGQ EEAFRGWAQA AFQAACETFC VGEDAKAAAR 
DIFSPKRSWK RQRYRLSTQA ESLQLLPGLT HVHRRKMFQA TILSVENLQS SKSTRATILV 
RLDTGGQEGL QYQPGDHIGV CPPNRPGLVE ALLSRVEDPP PSTEPVAVEQ LEKGSPGGPP 
PGWVRDPRLP PCTLRQALTY FLDITSPPSP RLLRLLSTLA EESSEQQELE ALSQDPRRYE 
EWKWFSCPTL LEVLEQFPSV ALPAPLILTQ LPLLQPRYYS VSSAPSAHPG EIHLTIAVLA 
YRTQDGLGPL HYGVCSTWMS QLKAGDPVPC FIRGAPSFRL PPDPNLPCIL VGPGTGIAPF 
RGFWQDRLHD IEIKGLQPAP MTLVFGCRCS QLDHLYRDEV LDAQQRGVFG QVLTAFSRDP 
GSPKTYVQDL LRTELAAEVH RVLCLEQGHM FVCGDVTMAT SVLQTVQRIL ATEGGMELDE 
AGDVIGVLRD QQRYHEDIFG LTLRTQEVTS RIRTQSFSLQ ERQLRGAVPW SFDPPGPEIP 
GS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nos3

Associated with

Other Information

Cloning and characterization of murine endothelial constitutive nitric oxide synthase. PubMed ID: 8764825

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Limb reduction defects in endothelial nitric oxide synthase-deficient mice. PubMed ID: 9843834

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Requirement of argininosuccinate lyase for systemic nitric oxide production. PubMed ID: 22081021

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073